The density of the class II MHC T cell receptor ligand influences IFN-gamma/IL-4 ratios in immune responses in vivo

Activation of CD4+ T cells depends on T cell receptor recognition of MHC class II/peptide and on costimulation provided by CD28/B7. It has been shown that different levels of costimulation can influence T helper cell differentiation into Th1 versus Th2 phenotypes. Similar arguments have been made fo...

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Veröffentlicht in:	Cellular immunology 1998-01, Vol.183 (1), p.70-79
Hauptverfasser:	DiMolfetto, L, Neal, H A, Wu, A, Reilly, C, Lo, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic AIDS/HIV Animals B-Lymphocytes - metabolism Cell Count Cells, Cultured Dendritic Cells - metabolism Female Gene Expression Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Interferon-gamma - immunology Interleukin-4 - immunology Ligands Lymph Nodes - immunology Lymphocyte Activation Male Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Antigen, T-Cell - immunology T-Lymphocytes - immunology Th1 Cells - immunology
Online-Zugang:	Volltext
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