Changes in the motor response to acute L-dopa challenge after unilateral microelectrode-guided posteroventral pallidotomy
To determine the effect of unilateral posteroventral pallidotomy (PVP) on latency and duration of response to L-dopa ipsilateral and contralateral to the side of the lesion, six severe fluctuating Hoehn-Yahr IV patients with Parkinson's disease were evaluated 2 days before and after unilateral...
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| Veröffentlicht in: | Clinical neuropharmacology 1998-03, Vol.21 (2), p.135-138 |
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| container_title | Clinical neuropharmacology |
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| creator | MERELLO, M NOUZEILLES, M. I CAMMAROTTA, A PIKIELNY, R LEIGUARDA, R |
| description | To determine the effect of unilateral posteroventral pallidotomy (PVP) on latency and duration of response to L-dopa ipsilateral and contralateral to the side of the lesion, six severe fluctuating Hoehn-Yahr IV patients with Parkinson's disease were evaluated 2 days before and after unilateral PVP. After an overnight drug holiday in a fasting state, patients were challenged with a single dose of 200/50 mg of L-dopa/ carbidopa. Sequential tapping tests every 5 minutes in both hands were used to measure changes in motor status. Duration of L-dopa effect was significantly longer after PVP (p < 0.03). Mean latency of the effect improved by 50% without reaching statistical significance. Despite a clear, asymmetric improvement of cardinal Parkinson's disease symptoms after unilateral PVP, changes in the dose-response L-dopa profile occurred symmetrically, suggesting that mechanisms underlying the two effects are distinct. |
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Despite a clear, asymmetric improvement of cardinal Parkinson's disease symptoms after unilateral PVP, changes in the dose-response L-dopa profile occurred symmetrically, suggesting that mechanisms underlying the two effects are distinct.</description><identifier>ISSN: 0362-5664</identifier><identifier>EISSN: 1537-162X</identifier><identifier>PMID: 9579303</identifier><identifier>CODEN: CLNEDB</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Analysis of Variance ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Antiparkinson Agents - pharmacology ; Antiparkinson Agents - therapeutic use ; Biological and medical sciences ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Female ; Globus Pallidus - surgery ; Humans ; Levodopa - pharmacology ; Levodopa - therapeutic use ; Male ; Medical sciences ; Microelectrodes ; Middle Aged ; Motor Activity - drug effects ; Neurologic Examination ; Neuropharmacology ; Parkinson Disease - drug therapy ; Parkinson Disease - surgery ; Pharmacology. 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I</creatorcontrib><creatorcontrib>CAMMAROTTA, A</creatorcontrib><creatorcontrib>PIKIELNY, R</creatorcontrib><creatorcontrib>LEIGUARDA, R</creatorcontrib><title>Changes in the motor response to acute L-dopa challenge after unilateral microelectrode-guided posteroventral pallidotomy</title><title>Clinical neuropharmacology</title><addtitle>Clin Neuropharmacol</addtitle><description>To determine the effect of unilateral posteroventral pallidotomy (PVP) on latency and duration of response to L-dopa ipsilateral and contralateral to the side of the lesion, six severe fluctuating Hoehn-Yahr IV patients with Parkinson's disease were evaluated 2 days before and after unilateral PVP. After an overnight drug holiday in a fasting state, patients were challenged with a single dose of 200/50 mg of L-dopa/ carbidopa. Sequential tapping tests every 5 minutes in both hands were used to measure changes in motor status. Duration of L-dopa effect was significantly longer after PVP (p < 0.03). Mean latency of the effect improved by 50% without reaching statistical significance. Despite a clear, asymmetric improvement of cardinal Parkinson's disease symptoms after unilateral PVP, changes in the dose-response L-dopa profile occurred symmetrically, suggesting that mechanisms underlying the two effects are distinct.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Antiparkinson Agents - pharmacology</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Globus Pallidus - surgery</subject><subject>Humans</subject><subject>Levodopa - pharmacology</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microelectrodes</subject><subject>Middle Aged</subject><subject>Motor Activity - drug effects</subject><subject>Neurologic Examination</subject><subject>Neuropharmacology</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - surgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><issn>0362-5664</issn><issn>1537-162X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMouq7-BCEH8VbIZz-OsvgFC14UvJXZdLobSZuapML-eyMWLzMDz_POwJyQFdeyKngpPk7JislSFLos1QW5jPGTMVY3qjkn542uGsnkihw3Bxj3GKkdaTogHXzygQaMkx8j0uQpmDkh3Radn4CaAziHOUChTxjoPFoHeQBHB2uCR4cmBd9hsZ9thx2dfMzYf-OYfqUpx22XbwzHK3LWg4t4vfQ1eX98eNs8F9vXp5fN_baYhNSpKBmigVxBw86wWvbK1EpoZEr2gusdoOC95sglgwqlkrrUpkLOZNU3TMo1ufvbOwX_NWNM7WCjQedgRD_Htmpq2TRcZfFmEefdgF07BTtAOLbLrzK_XThEA64PMBob_zUhFGNKyR9h7HW8</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>MERELLO, M</creator><creator>NOUZEILLES, M. 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Antiparkinson agents</topic><topic>Antiparkinson Agents - pharmacology</topic><topic>Antiparkinson Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Globus Pallidus - surgery</topic><topic>Humans</topic><topic>Levodopa - pharmacology</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microelectrodes</topic><topic>Middle Aged</topic><topic>Motor Activity - drug effects</topic><topic>Neurologic Examination</topic><topic>Neuropharmacology</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson Disease - surgery</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MERELLO, M</creatorcontrib><creatorcontrib>NOUZEILLES, M. I</creatorcontrib><creatorcontrib>CAMMAROTTA, A</creatorcontrib><creatorcontrib>PIKIELNY, R</creatorcontrib><creatorcontrib>LEIGUARDA, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MERELLO, M</au><au>NOUZEILLES, M. I</au><au>CAMMAROTTA, A</au><au>PIKIELNY, R</au><au>LEIGUARDA, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the motor response to acute L-dopa challenge after unilateral microelectrode-guided posteroventral pallidotomy</atitle><jtitle>Clinical neuropharmacology</jtitle><addtitle>Clin Neuropharmacol</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>21</volume><issue>2</issue><spage>135</spage><epage>138</epage><pages>135-138</pages><issn>0362-5664</issn><eissn>1537-162X</eissn><coden>CLNEDB</coden><abstract>To determine the effect of unilateral posteroventral pallidotomy (PVP) on latency and duration of response to L-dopa ipsilateral and contralateral to the side of the lesion, six severe fluctuating Hoehn-Yahr IV patients with Parkinson's disease were evaluated 2 days before and after unilateral PVP. After an overnight drug holiday in a fasting state, patients were challenged with a single dose of 200/50 mg of L-dopa/ carbidopa. Sequential tapping tests every 5 minutes in both hands were used to measure changes in motor status. Duration of L-dopa effect was significantly longer after PVP (p < 0.03). Mean latency of the effect improved by 50% without reaching statistical significance. Despite a clear, asymmetric improvement of cardinal Parkinson's disease symptoms after unilateral PVP, changes in the dose-response L-dopa profile occurred symmetrically, suggesting that mechanisms underlying the two effects are distinct.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>9579303</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0362-5664 |
| ispartof | Clinical neuropharmacology, 1998-03, Vol.21 (2), p.135-138 |
| issn | 0362-5664 1537-162X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Analysis of Variance Anticonvulsants. Antiepileptics. Antiparkinson agents Antiparkinson Agents - pharmacology Antiparkinson Agents - therapeutic use Biological and medical sciences Combined Modality Therapy Dose-Response Relationship, Drug Female Globus Pallidus - surgery Humans Levodopa - pharmacology Levodopa - therapeutic use Male Medical sciences Microelectrodes Middle Aged Motor Activity - drug effects Neurologic Examination Neuropharmacology Parkinson Disease - drug therapy Parkinson Disease - surgery Pharmacology. Drug treatments Prospective Studies |
| title | Changes in the motor response to acute L-dopa challenge after unilateral microelectrode-guided posteroventral pallidotomy |
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