Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

Three mitogen-activated protein kinase pathways are up-regulated during the activation of T lymphocytes, the extracellular signal-regulated kinase (ERK), Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase pathways. To examine the effects of blocking the ERK pathway on T cell activatio...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-05, Vol.160 (9), p.4175-4181
Hauptverfasser:	DeSilva, Dimuthu R, Jones, Elizabeth A, Favata, Margaret F, Jaffee, Bruce D, Magolda, Ronald L, Trzaskos, James M, Scherle, Peggy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD28 Antigens - immunology CD3 Complex - immunology Cell Division - immunology Clone Cells Interleukin-2 - immunology Lymphocyte Activation Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinase Kinases Protein Kinases - immunology Signal Transduction - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology
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