Tumor‐specific peptides in cutaneous T‐cell lymphoma: Association with class I major histocompatibility complex and possible derivation from the clonotypic T‐cell receptor

We wished to identify and characterize tumor‐associated class I peptides which could potentially serve as immunogens for an immunoprotective CD8 response in cutaneous T‐cell lymphoma (CTCL). Candidate idiotypic peptides were identified from the third complementarity determining region (CDR3) of the...

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Veröffentlicht in:	International journal of cancer 1998-05, Vol.76 (3), p.304-311
Hauptverfasser:	Berger, Carole L., Longley, B. Jack, Imaeda, Suguru, Christensen, Inger, Heald, Peter, Edelson, Richard L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Antigens, Neoplasm - chemistry Antigens, Neoplasm - genetics Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Genes, T-Cell Receptor beta - genetics Hematologic and hematopoietic diseases Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - genetics Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, T-Cell, Cutaneous - blood Lymphoma, T-Cell, Cutaneous - immunology Medical sciences Molecular Sequence Data Peptides - analysis Peptides - immunology Peptides - isolation & purification Protein Conformation Sequence Alignment Sequence Homology, Amino Acid Skin Neoplasms - blood Skin Neoplasms - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor Necrosis Factor-alpha - metabolism
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