Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. A report of three cases
Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with...
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| Veröffentlicht in: | Journal of neurology 1990-04, Vol.237 (2), p.113-116 |
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| container_end_page | 116 |
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| container_title | Journal of neurology |
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| creator | MEURERS, B KOHLHEPP, W GOLD, R ROHRBACH, E MERTENS, H. G |
| description | Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system. |
| doi_str_mv | 10.1007/BF00314674 |
| format | Article |
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Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Borrelia infections</subject><subject>Central Nervous System - pathology</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lyme Disease - complications</subject><subject>Lyme Disease - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous System Diseases - etiology</subject><subject>Nervous System Diseases - pathology</subject><subject>Peripheral Nerves - pathology</subject><subject>Tropical bacterial diseases</subject><subject>Vasculitis - etiology</subject><subject>Vasculitis - pathology</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotVYv3oVc9CBsTTb7lWMt1goFD3pfstnZNrJN1syu0H9vaos9DGHmfXgILyG3nE05Y_nT84IxwZMsT87ImCcijniSynMyZiJhUSrS5JJcIX4xxooQjMgoFmkaZkyGpcHedarfuNatjVYtbYytjV0jNZb2G6AabO_DXdmaduBNt4H9asH_uAEp7rCH7R9tYfCuct5DaxwanNIZ9dA531PXBJeHYFMIeE0uGtUi3BzfCflYvHzOl9Hq_fVtPltFmhdZH3EpoI4zkelYSUhiHkuRS-Apq_K6SSsJQimeqVowXoR7oJjUSmeyqmstJuThYO28-x4A-3JrUEPbKgvh52UuC1HwNAvg4wHU3iF6aMrOm63yu5Kzct9weWo4wHdH61Btof5Hj5WG_P6YKwx1Nl5ZbfBklAnLuGTiF1_JhLA</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>MEURERS, B</creator><creator>KOHLHEPP, W</creator><creator>GOLD, R</creator><creator>ROHRBACH, E</creator><creator>MERTENS, H. 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A report of three cases</atitle><jtitle>Journal of neurology</jtitle><addtitle>J Neurol</addtitle><date>1990-04</date><risdate>1990</risdate><volume>237</volume><issue>2</issue><spage>113</spage><epage>116</epage><pages>113-116</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><coden>JNRYA9</coden><abstract>Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2355235</pmid><doi>10.1007/BF00314674</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of neurology, 1990-04, Vol.237 (2), p.113-116 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Bacterial diseases Biological and medical sciences Biopsy Borrelia infections Central Nervous System - pathology Female Human bacterial diseases Humans Infectious diseases Lyme Disease - complications Lyme Disease - pathology Male Medical sciences Middle Aged Nervous System Diseases - etiology Nervous System Diseases - pathology Peripheral Nerves - pathology Tropical bacterial diseases Vasculitis - etiology Vasculitis - pathology |
| title | Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. A report of three cases |
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