Leukoagglutinins in patients with hemophilia
Anti-leukocyte antibodies may occur in hemophilic patients as a consequence of replacement therapy with blood derivatives. In this report we describe the presence of leukoagglutinis (LA) in serum of HIV-infected hemophiliacs (HIV+He) and their absence in HIV-negative patients (HIVHe). LA activity w...
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| Veröffentlicht in: | Immunology letters 1990-05, Vol.24 (2), p.107-111 |
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| creator | Riera, Norma E. Galassi, Nora Anselmo, Armando Aixala, Monica Bouza, Maria B. de Bracco, Maria M.E. |
| description | Anti-leukocyte antibodies may occur in hemophilic patients as a consequence of replacement therapy with blood derivatives. In this report we describe the presence of leukoagglutinis (LA) in serum of HIV-infected hemophiliacs (HIV+He) and their absence in HIV-negative patients (HIVHe). LA activity was recovered in IgG fractions from HIV+He, in the polyethylene glycol (PEG) precipitates from these sera, and in some cases in the supernatant fractions of PEG precipitates. Although the amount of PEG precipitates corresponding to circulating immune complexes (CIC) was higher in HIV+He than in HIV-He and normals, there was no direct relationship between CIC levels and LA. LA reacted both with autologous and with allogeneic polymorphonuclear leukocytes (PMN). In contrast to PMN isolated from HIV-He, HIV+He PMN had membrane associated IgG. In HIV+He, LA activity was more frequently observed in patients with more advanced stages of HIV infection than in asymptomatic individuals. Our results suggest that LA activity could be one of the manifestations of autoreactivity associated with progressing HIV infection in patients with hemophilia. |
| doi_str_mv | 10.1016/0165-2478(90)90020-Q |
| format | Article |
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In this report we describe the presence of leukoagglutinis (LA) in serum of HIV-infected hemophiliacs (HIV+He) and their absence in HIV-negative patients (HIVHe). LA activity was recovered in IgG fractions from HIV+He, in the polyethylene glycol (PEG) precipitates from these sera, and in some cases in the supernatant fractions of PEG precipitates. Although the amount of PEG precipitates corresponding to circulating immune complexes (CIC) was higher in HIV+He than in HIV-He and normals, there was no direct relationship between CIC levels and LA. LA reacted both with autologous and with allogeneic polymorphonuclear leukocytes (PMN). In contrast to PMN isolated from HIV-He, HIV+He PMN had membrane associated IgG. In HIV+He, LA activity was more frequently observed in patients with more advanced stages of HIV infection than in asymptomatic individuals. Our results suggest that LA activity could be one of the manifestations of autoreactivity associated with progressing HIV infection in patients with hemophilia.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/0165-2478(90)90020-Q</identifier><identifier>PMID: 2354863</identifier><identifier>CODEN: IMLED6</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Anti-leukocyte antibody ; Antigen-Antibody Complex - analysis ; Autoantibodies - biosynthesis ; Autoimmunity ; Biological and medical sciences ; Child ; Circulating immune complex ; Haemophilia ; Hemophilia A - complications ; Hemophilia A - immunology ; HIV infection ; HIV Seropositivity - complications ; HIV Seropositivity - immunology ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - immunology ; Immunopathology ; Leukoagglutinins ; Leukocytes - immunology ; Medical sciences ; Neutrophils - immunology</subject><ispartof>Immunology letters, 1990-05, Vol.24 (2), p.107-111</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-73a4ef75f98f180643be4f26e3665fbea8ae8ffb492b55cf90b2258afa342ea03</citedby><cites>FETCH-LOGICAL-c386t-73a4ef75f98f180643be4f26e3665fbea8ae8ffb492b55cf90b2258afa342ea03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-2478(90)90020-Q$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6923218$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2354863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riera, Norma E.</creatorcontrib><creatorcontrib>Galassi, Nora</creatorcontrib><creatorcontrib>Anselmo, Armando</creatorcontrib><creatorcontrib>Aixala, Monica</creatorcontrib><creatorcontrib>Bouza, Maria B.</creatorcontrib><creatorcontrib>de Bracco, Maria M.E.</creatorcontrib><title>Leukoagglutinins in patients with hemophilia</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Anti-leukocyte antibodies may occur in hemophilic patients as a consequence of replacement therapy with blood derivatives. In this report we describe the presence of leukoagglutinis (LA) in serum of HIV-infected hemophiliacs (HIV+He) and their absence in HIV-negative patients (HIVHe). LA activity was recovered in IgG fractions from HIV+He, in the polyethylene glycol (PEG) precipitates from these sera, and in some cases in the supernatant fractions of PEG precipitates. Although the amount of PEG precipitates corresponding to circulating immune complexes (CIC) was higher in HIV+He than in HIV-He and normals, there was no direct relationship between CIC levels and LA. LA reacted both with autologous and with allogeneic polymorphonuclear leukocytes (PMN). In contrast to PMN isolated from HIV-He, HIV+He PMN had membrane associated IgG. In HIV+He, LA activity was more frequently observed in patients with more advanced stages of HIV infection than in asymptomatic individuals. Our results suggest that LA activity could be one of the manifestations of autoreactivity associated with progressing HIV infection in patients with hemophilia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Anti-leukocyte antibody</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Autoantibodies - biosynthesis</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Circulating immune complex</subject><subject>Haemophilia</subject><subject>Hemophilia A - complications</subject><subject>Hemophilia A - immunology</subject><subject>HIV infection</subject><subject>HIV Seropositivity - complications</subject><subject>HIV Seropositivity - immunology</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunopathology</subject><subject>Leukoagglutinins</subject><subject>Leukocytes - immunology</subject><subject>Medical sciences</subject><subject>Neutrophils - immunology</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQx4Mo6_r4Bgo9iChYTfNok4sgiy9YkAU9hzQ72Y32ZdIqfntbt-zRwzCH-f1nhh9CJwm-TnCS3vTFY8IycSHxpcSY4Hixg6aJyGSMOSO7aLpF9tFBCO8YJ5wyOkETQjkTKZ2iqzl0H7VerYqudZWrQuSqqNGtg6oN0bdr19EayrpZu8LpI7RndRHgeOyH6O3h_nX2FM9fHp9nd_PYUJG2cUY1A5txK4VNBE4ZzYFZkgJNU25z0EKDsDZnkuScGytxTggX2mrKCGhMD9H5Zm_j688OQqtKFwwUha6g7oLKpKCZpKIH2QY0vg7Bg1WNd6X2PyrBapCkBgNqMKAkVn-S1KKPnY77u7yE5TY0WunnZ-NcB6ML63VlXNhiqSSUJMP12w0GvYsvB14F03szsHQeTKuWtfv_j1_sU4Kx</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Riera, Norma E.</creator><creator>Galassi, Nora</creator><creator>Anselmo, Armando</creator><creator>Aixala, Monica</creator><creator>Bouza, Maria B.</creator><creator>de Bracco, Maria M.E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900501</creationdate><title>Leukoagglutinins in patients with hemophilia</title><author>Riera, Norma E. ; Galassi, Nora ; Anselmo, Armando ; Aixala, Monica ; Bouza, Maria B. ; de Bracco, Maria M.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-73a4ef75f98f180643be4f26e3665fbea8ae8ffb492b55cf90b2258afa342ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Anti-leukocyte antibody</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Autoantibodies - biosynthesis</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Circulating immune complex</topic><topic>Haemophilia</topic><topic>Hemophilia A - complications</topic><topic>Hemophilia A - immunology</topic><topic>HIV infection</topic><topic>HIV Seropositivity - complications</topic><topic>HIV Seropositivity - immunology</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunopathology</topic><topic>Leukoagglutinins</topic><topic>Leukocytes - immunology</topic><topic>Medical sciences</topic><topic>Neutrophils - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riera, Norma E.</creatorcontrib><creatorcontrib>Galassi, Nora</creatorcontrib><creatorcontrib>Anselmo, Armando</creatorcontrib><creatorcontrib>Aixala, Monica</creatorcontrib><creatorcontrib>Bouza, Maria B.</creatorcontrib><creatorcontrib>de Bracco, Maria M.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riera, Norma E.</au><au>Galassi, Nora</au><au>Anselmo, Armando</au><au>Aixala, Monica</au><au>Bouza, Maria B.</au><au>de Bracco, Maria M.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukoagglutinins in patients with hemophilia</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>24</volume><issue>2</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><coden>IMLED6</coden><abstract>Anti-leukocyte antibodies may occur in hemophilic patients as a consequence of replacement therapy with blood derivatives. In this report we describe the presence of leukoagglutinis (LA) in serum of HIV-infected hemophiliacs (HIV+He) and their absence in HIV-negative patients (HIVHe). LA activity was recovered in IgG fractions from HIV+He, in the polyethylene glycol (PEG) precipitates from these sera, and in some cases in the supernatant fractions of PEG precipitates. Although the amount of PEG precipitates corresponding to circulating immune complexes (CIC) was higher in HIV+He than in HIV-He and normals, there was no direct relationship between CIC levels and LA. LA reacted both with autologous and with allogeneic polymorphonuclear leukocytes (PMN). In contrast to PMN isolated from HIV-He, HIV+He PMN had membrane associated IgG. In HIV+He, LA activity was more frequently observed in patients with more advanced stages of HIV infection than in asymptomatic individuals. Our results suggest that LA activity could be one of the manifestations of autoreactivity associated with progressing HIV infection in patients with hemophilia.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2354863</pmid><doi>10.1016/0165-2478(90)90020-Q</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult AIDS/HIV Anti-leukocyte antibody Antigen-Antibody Complex - analysis Autoantibodies - biosynthesis Autoimmunity Biological and medical sciences Child Circulating immune complex Haemophilia Hemophilia A - complications Hemophilia A - immunology HIV infection HIV Seropositivity - complications HIV Seropositivity - immunology Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Immunopathology Leukoagglutinins Leukocytes - immunology Medical sciences Neutrophils - immunology |
| title | Leukoagglutinins in patients with hemophilia |
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