Maturational changes in cell surface antigen expression in the mouse retina and optic pathway
The distribution of the cell surface molecules M6 and L1 was studied using the immunohistochemistry and in situ hybridization in the developing and adult mouse retina and optic nerve. L1 is a cell adhesion molecule while M6 is a cell surface molecule homologous to the myelin protein proteolipid prot...
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| Veröffentlicht in: | Brain research. Developmental brain research 1998-03, Vol.106 (1), p.145-154 |
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| container_title | Brain research. Developmental brain research |
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| creator | Mi, Zhi-Ping Weng, Weili Hankin, Mark H Narayanan, Vinodh Lagenaur, Carl F |
| description | The distribution of the cell surface molecules M6 and L1 was studied using the immunohistochemistry and in situ hybridization in the developing and adult mouse retina and optic nerve. L1 is a cell adhesion molecule while M6 is a cell surface molecule homologous to the myelin protein proteolipid protein (PLP/DM20). Although both molecules were expressed in retina and optic nerves of embryonic and neonatal mice, our studies show that their patterns of postnatal expression are quite different. While L1 continues to be expressed in optic axons throughout adulthood, expression of M6 on optic axons declines after birth and instead becomes strongly expressed on Müller glial endfeet and in the inner plexiform layer. The modulation of these molecules after birth could provide clues to changing cell–cell interactions occurring in the proximal portion of the optic pathway. |
| doi_str_mv | 10.1016/S0165-3806(97)00206-X |
| format | Article |
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L1 is a cell adhesion molecule while M6 is a cell surface molecule homologous to the myelin protein proteolipid protein (PLP/DM20). Although both molecules were expressed in retina and optic nerves of embryonic and neonatal mice, our studies show that their patterns of postnatal expression are quite different. While L1 continues to be expressed in optic axons throughout adulthood, expression of M6 on optic axons declines after birth and instead becomes strongly expressed on Müller glial endfeet and in the inner plexiform layer. The modulation of these molecules after birth could provide clues to changing cell–cell interactions occurring in the proximal portion of the optic pathway.</description><identifier>ISSN: 0165-3806</identifier><identifier>DOI: 10.1016/S0165-3806(97)00206-X</identifier><identifier>PMID: 9554989</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antigens, Surface - immunology ; Embryonic and Fetal Development - physiology ; Immunohistochemistry ; In Situ Hybridization ; Mice ; Mice, Inbred C57BL ; Nerve Fibers - immunology ; Optic fibers ; Optic Nerve - embryology ; Optic Nerve - growth & development ; Optic Nerve - immunology ; Retina - embryology ; Retina - growth & development ; Retina - immunology ; Retinal ganglion cell ; Visual Pathways - embryology ; Visual Pathways - growth & development ; Visual Pathways - immunology</subject><ispartof>Brain research. 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Developmental brain research</title><addtitle>Brain Res Dev Brain Res</addtitle><description>The distribution of the cell surface molecules M6 and L1 was studied using the immunohistochemistry and in situ hybridization in the developing and adult mouse retina and optic nerve. L1 is a cell adhesion molecule while M6 is a cell surface molecule homologous to the myelin protein proteolipid protein (PLP/DM20). Although both molecules were expressed in retina and optic nerves of embryonic and neonatal mice, our studies show that their patterns of postnatal expression are quite different. While L1 continues to be expressed in optic axons throughout adulthood, expression of M6 on optic axons declines after birth and instead becomes strongly expressed on Müller glial endfeet and in the inner plexiform layer. The modulation of these molecules after birth could provide clues to changing cell–cell interactions occurring in the proximal portion of the optic pathway.</description><subject>Animals</subject><subject>Antigens, Surface - immunology</subject><subject>Embryonic and Fetal Development - physiology</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nerve Fibers - immunology</subject><subject>Optic fibers</subject><subject>Optic Nerve - embryology</subject><subject>Optic Nerve - growth & development</subject><subject>Optic Nerve - immunology</subject><subject>Retina - embryology</subject><subject>Retina - growth & development</subject><subject>Retina - immunology</subject><subject>Retinal ganglion cell</subject><subject>Visual Pathways - embryology</subject><subject>Visual Pathways - growth & development</subject><subject>Visual Pathways - immunology</subject><issn>0165-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAQgD2ASin8hEqeEAwBO27iZEII8ZKKGACpC7Ic59wa5YXtAP33OG3VleV88n3n830ITSm5pISmV68hJBHLSHqe8wtCYpJGiwM03l8foWPnPgkhlGV0hEZ5kszyLB-jj2fpeyu9aRtZYbWSzRIcNg1WUFXY9VZLBVg23iyhwfDbWXAuwAPiV4DrtneALXjTyICVuO28UbiTfvUj1yfoUMvKwenunKD3-7u328do_vLwdHszjxRLiY8o1YlmOUlYBgUwrmSc6lRSpoo45EppLYus0JQyDmVaAi1izjNNpeJAZhmboLPtu51tv3pwXtTGDRvIBsIHBc8zxtN8FsBkCyrbOmdBi86aWtq1oEQMKsVGpRiciZyLjUqxCH3T3YC-qKHcd-08hvr1tg5hy28DVjhloFFQGgvKi7I1_0z4Ax43h-0</recordid><startdate>19980312</startdate><enddate>19980312</enddate><creator>Mi, Zhi-Ping</creator><creator>Weng, Weili</creator><creator>Hankin, Mark H</creator><creator>Narayanan, Vinodh</creator><creator>Lagenaur, Carl F</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980312</creationdate><title>Maturational changes in cell surface antigen expression in the mouse retina and optic pathway</title><author>Mi, Zhi-Ping ; Weng, Weili ; Hankin, Mark H ; Narayanan, Vinodh ; Lagenaur, Carl F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-11f5f390538ebe37ca26f6a13cb2ca2ccffab8bf1137ed6de1b2778f1ac7e0483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antigens, Surface - immunology</topic><topic>Embryonic and Fetal Development - physiology</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nerve Fibers - immunology</topic><topic>Optic fibers</topic><topic>Optic Nerve - embryology</topic><topic>Optic Nerve - growth & development</topic><topic>Optic Nerve - immunology</topic><topic>Retina - embryology</topic><topic>Retina - growth & development</topic><topic>Retina - immunology</topic><topic>Retinal ganglion cell</topic><topic>Visual Pathways - embryology</topic><topic>Visual Pathways - growth & development</topic><topic>Visual Pathways - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mi, Zhi-Ping</creatorcontrib><creatorcontrib>Weng, Weili</creatorcontrib><creatorcontrib>Hankin, Mark H</creatorcontrib><creatorcontrib>Narayanan, Vinodh</creatorcontrib><creatorcontrib>Lagenaur, Carl F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. Developmental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mi, Zhi-Ping</au><au>Weng, Weili</au><au>Hankin, Mark H</au><au>Narayanan, Vinodh</au><au>Lagenaur, Carl F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maturational changes in cell surface antigen expression in the mouse retina and optic pathway</atitle><jtitle>Brain research. Developmental brain research</jtitle><addtitle>Brain Res Dev Brain Res</addtitle><date>1998-03-12</date><risdate>1998</risdate><volume>106</volume><issue>1</issue><spage>145</spage><epage>154</epage><pages>145-154</pages><issn>0165-3806</issn><abstract>The distribution of the cell surface molecules M6 and L1 was studied using the immunohistochemistry and in situ hybridization in the developing and adult mouse retina and optic nerve. L1 is a cell adhesion molecule while M6 is a cell surface molecule homologous to the myelin protein proteolipid protein (PLP/DM20). Although both molecules were expressed in retina and optic nerves of embryonic and neonatal mice, our studies show that their patterns of postnatal expression are quite different. While L1 continues to be expressed in optic axons throughout adulthood, expression of M6 on optic axons declines after birth and instead becomes strongly expressed on Müller glial endfeet and in the inner plexiform layer. The modulation of these molecules after birth could provide clues to changing cell–cell interactions occurring in the proximal portion of the optic pathway.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9554989</pmid><doi>10.1016/S0165-3806(97)00206-X</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research. Developmental brain research, 1998-03, Vol.106 (1), p.145-154 |
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| language | eng |
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| subjects | Animals Antigens, Surface - immunology Embryonic and Fetal Development - physiology Immunohistochemistry In Situ Hybridization Mice Mice, Inbred C57BL Nerve Fibers - immunology Optic fibers Optic Nerve - embryology Optic Nerve - growth & development Optic Nerve - immunology Retina - embryology Retina - growth & development Retina - immunology Retinal ganglion cell Visual Pathways - embryology Visual Pathways - growth & development Visual Pathways - immunology |
| title | Maturational changes in cell surface antigen expression in the mouse retina and optic pathway |
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