Thrombopoietin (TPO) Knockout Phenotype Induced by Cross-Reactive Antibodies Against TPO Following Injection of Mice with Recombinant Adenovirus Encoding Human TPO

Adenovirus vectors have emerged as potent agents for gene transfer. Immune response against the vector and the encoded protein is one of the major factors in the transient expression following in vivo gene transfer. A single injection of an adenovirus encoding human thrombopoietin (TPO) into mice in...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-05, Vol.160 (9), p.4481-4489
Hauptverfasser:	Abina, Mohammed-Amine, Tulliez, Micheline, Duffour, Marie-Therese, Debili, Najet, Lacout, Catherine, Villeval, Jean-Luc, Wendling, Francoise, Vainchenker, William, Haddada, Hedi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - immunology Animals Antibodies - immunology Antibody Specificity Cross Reactions Gene Transfer Techniques Genetic Vectors - immunology Humans Mice Recombinant Proteins - immunology Thrombocytopenia - immunology Thrombopoietin - immunology
Online-Zugang:	Volltext
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