Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model
A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin pr...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1998-03, Vol.41 (3), p.403-405 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | SHAPIRO, M. A SESNIE, J. C DESATY, T. M GRIFFIN, T. J HEIFETZ, C. L |
| description | A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested. |
| doi_str_mv | 10.1093/jac/41.3.403 |
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A ; SESNIE, J. C ; DESATY, T. M ; GRIFFIN, T. J ; HEIFETZ, C. L</creator><creatorcontrib>SHAPIRO, M. A ; SESNIE, J. C ; DESATY, T. M ; GRIFFIN, T. J ; HEIFETZ, C. L</creatorcontrib><description>A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/41.3.403</identifier><identifier>PMID: 9578169</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Abscess - drug therapy ; Abscess - etiology ; Abscess - microbiology ; Animals ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - blood ; Anti-Infective Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Area Under Curve ; Biological and medical sciences ; Ceftazidime - administration & dosage ; Ceftazidime - blood ; Ceftazidime - pharmacology ; Cilastatin - blood ; Cilastatin - pharmacology ; Cilastatin, Imipenem Drug Combination ; Ciprofloxacin - administration & dosage ; Ciprofloxacin - blood ; Ciprofloxacin - therapeutic use ; Colony Count, Microbial ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Combinations ; Drug Therapy, Combination - blood ; Drug Therapy, Combination - pharmacology ; Female ; Fluoroquinolones ; Half-Life ; Imipenem - blood ; Imipenem - pharmacology ; Kidney - drug effects ; Kidney - microbiology ; Kidney Diseases - drug therapy ; Kidney Diseases - etiology ; Kidney Diseases - microbiology ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - complications ; Pseudomonas Infections - drug therapy ; Pseudomonas Infections - microbiology ; Quinolones - administration & dosage ; Quinolones - blood ; Quinolones - therapeutic use ; Treatment Outcome</subject><ispartof>Journal of antimicrobial chemotherapy, 1998-03, Vol.41 (3), p.403-405</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-efb0c18035f2a9667979c45c79a8ce36ed15e987abff2ff0337f802c88b238f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2205084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9578169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHAPIRO, M. A</creatorcontrib><creatorcontrib>SESNIE, J. C</creatorcontrib><creatorcontrib>DESATY, T. M</creatorcontrib><creatorcontrib>GRIFFIN, T. J</creatorcontrib><creatorcontrib>HEIFETZ, C. L</creatorcontrib><title>Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested.</description><subject>Abscess - drug therapy</subject><subject>Abscess - etiology</subject><subject>Abscess - microbiology</subject><subject>Animals</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - blood</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Ceftazidime - administration & dosage</subject><subject>Ceftazidime - blood</subject><subject>Ceftazidime - pharmacology</subject><subject>Cilastatin - blood</subject><subject>Cilastatin - pharmacology</subject><subject>Cilastatin, Imipenem Drug Combination</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Ciprofloxacin - blood</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Colony Count, Microbial</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Combinations</subject><subject>Drug Therapy, Combination - blood</subject><subject>Drug Therapy, Combination - pharmacology</subject><subject>Female</subject><subject>Fluoroquinolones</subject><subject>Half-Life</subject><subject>Imipenem - blood</subject><subject>Imipenem - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - microbiology</subject><subject>Kidney Diseases - drug therapy</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - microbiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - complications</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Pseudomonas Infections - microbiology</subject><subject>Quinolones - administration & dosage</subject><subject>Quinolones - blood</subject><subject>Quinolones - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rHDEMxU1JSbdpb7kGfCg5dTb2-PtYlvQDAu2hPRuNV04cZsZbe6Yk_30dsuQaEAj0fkgPPULOOdty5sTVPYQrybdiK5l4QzZcatb1zPETsmGCqc5IJd6R97XeM8a00vaUnDplLNduQ253eTpAgSX9Q7rcYYEDrksKFGNMAcIjzZGGMc0Qx_wAIc20FdBfFdd9nvIMlQKW9TbNuQKd8lqRFpxhpDDUgLW22R7HD-RthLHix2M_I3--Xv_efe9ufn77sfty0wVh5dJhHFjglgkVe3BaG2dckCoYBzag0LjnCp01MMTYx8iEMNGyPlg79MJGI87I5fPeQ8l_V6yLn1KzMY4wY_PmjbNCuXbgNZBraXoldAM_P4Oh5FoLRn8oaYLy6DnzTwH4FoCX3AvfAmj4xXHvOky4f4GPH2_6p6MONcAYC8wh1Res75liVor_ZhyPXw</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>SHAPIRO, M. A</creator><creator>SESNIE, J. C</creator><creator>DESATY, T. M</creator><creator>GRIFFIN, T. J</creator><creator>HEIFETZ, C. L</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model</title><author>SHAPIRO, M. A ; SESNIE, J. C ; DESATY, T. M ; GRIFFIN, T. J ; HEIFETZ, C. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-efb0c18035f2a9667979c45c79a8ce36ed15e987abff2ff0337f802c88b238f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Abscess - drug therapy</topic><topic>Abscess - etiology</topic><topic>Abscess - microbiology</topic><topic>Animals</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - blood</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Ceftazidime - administration & dosage</topic><topic>Ceftazidime - blood</topic><topic>Ceftazidime - pharmacology</topic><topic>Cilastatin - blood</topic><topic>Cilastatin - pharmacology</topic><topic>Cilastatin, Imipenem Drug Combination</topic><topic>Ciprofloxacin - administration & dosage</topic><topic>Ciprofloxacin - blood</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Colony Count, Microbial</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Combinations</topic><topic>Drug Therapy, Combination - blood</topic><topic>Drug Therapy, Combination - pharmacology</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Half-Life</topic><topic>Imipenem - blood</topic><topic>Imipenem - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Kidney - microbiology</topic><topic>Kidney Diseases - drug therapy</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - microbiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Pseudomonas Infections - complications</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Pseudomonas Infections - microbiology</topic><topic>Quinolones - administration & dosage</topic><topic>Quinolones - blood</topic><topic>Quinolones - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHAPIRO, M. A</creatorcontrib><creatorcontrib>SESNIE, J. C</creatorcontrib><creatorcontrib>DESATY, T. M</creatorcontrib><creatorcontrib>GRIFFIN, T. J</creatorcontrib><creatorcontrib>HEIFETZ, C. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>41</volume><issue>3</issue><spage>403</spage><epage>405</epage><pages>403-405</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. 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| ispartof | Journal of antimicrobial chemotherapy, 1998-03, Vol.41 (3), p.403-405 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Free Full-Text Journals in Chemistry |
| subjects | Abscess - drug therapy Abscess - etiology Abscess - microbiology Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - blood Anti-Infective Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Area Under Curve Biological and medical sciences Ceftazidime - administration & dosage Ceftazidime - blood Ceftazidime - pharmacology Cilastatin - blood Cilastatin - pharmacology Cilastatin, Imipenem Drug Combination Ciprofloxacin - administration & dosage Ciprofloxacin - blood Ciprofloxacin - therapeutic use Colony Count, Microbial Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Drug Therapy, Combination - blood Drug Therapy, Combination - pharmacology Female Fluoroquinolones Half-Life Imipenem - blood Imipenem - pharmacology Kidney - drug effects Kidney - microbiology Kidney Diseases - drug therapy Kidney Diseases - etiology Kidney Diseases - microbiology Medical sciences Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - complications Pseudomonas Infections - drug therapy Pseudomonas Infections - microbiology Quinolones - administration & dosage Quinolones - blood Quinolones - therapeutic use Treatment Outcome |
| title | Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model |
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