The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children
Influenza A and B viruses are among the most common causes of respiratory tract illnesses that bring children to medical care, and influenza is a major cause of lower respiratory tract illness in young children. 1 The annual incidence of influenza infection in children may exceed 30 percent, 2 and c...
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| Veröffentlicht in: | The New England journal of medicine 1998-05, Vol.338 (20), p.1405-1412 |
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| container_title | The New England journal of medicine |
| container_volume | 338 |
| creator | Belshe, Robert B Mendelman, Paul M Treanor, John King, James Gruber, William C Piedra, Pedro Bernstein, David I Hayden, Frederick G Kotloff, Karen Zangwill, Ken Iacuzio, Dominick Wolff, Mark |
| description | Influenza A and B viruses are among the most common causes of respiratory tract illnesses that bring children to medical care, and influenza is a major cause of lower respiratory tract illness in young children.
1
The annual incidence of influenza infection in children may exceed 30 percent,
2
and children are believed to be important in the spread of influenza in the community.
3
Despite the availability of inactivated influenzavirus vaccine for children, the vaccine is used infrequently in this age group.
4
Live attenuated, cold-adapted, trivalent influenzavirus vaccine that is given intranasally may represent a convenient and effective approach to the prevention . . . |
| doi_str_mv | 10.1056/NEJM199805143382002 |
| format | Article |
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1
The annual incidence of influenza infection in children may exceed 30 percent,
2
and children are believed to be important in the spread of influenza in the community.
3
Despite the availability of inactivated influenzavirus vaccine for children, the vaccine is used infrequently in this age group.
4
Live attenuated, cold-adapted, trivalent influenzavirus vaccine that is given intranasally may represent a convenient and effective approach to the prevention . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199805143382002</identifier><identifier>PMID: 9580647</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject><![CDATA[Administration, Intranasal ; Antibodies, Viral - blood ; Biological and medical sciences ; Child, Preschool ; Children & youth ; Double-Blind Method ; Epidemiology. Vaccinations ; Female ; Fever - etiology ; Fever - prevention & control ; General aspects ; Humans ; Infant ; Infectious diseases ; Influenza ; Influenza A virus - immunology ; Influenza B virus - immunology ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - adverse effects ; Influenza Vaccines - immunology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Male ; Medical research ; Medical sciences ; Otitis Media - prevention & control ; Prospective Studies ; Treatment Outcome ; Vaccines ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - adverse effects ; Vaccines, Attenuated - immunology]]></subject><ispartof>The New England journal of medicine, 1998-05, Vol.338 (20), p.1405-1412</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-d8485358a9167a97ab5ee07c728ddefd804391def276c710fc384ade660710e33</citedby><cites>FETCH-LOGICAL-c625t-d8485358a9167a97ab5ee07c728ddefd804391def276c710fc384ade660710e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199805143382002$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223945881?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2229421$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9580647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belshe, Robert B</creatorcontrib><creatorcontrib>Mendelman, Paul M</creatorcontrib><creatorcontrib>Treanor, John</creatorcontrib><creatorcontrib>King, James</creatorcontrib><creatorcontrib>Gruber, William C</creatorcontrib><creatorcontrib>Piedra, Pedro</creatorcontrib><creatorcontrib>Bernstein, David I</creatorcontrib><creatorcontrib>Hayden, Frederick G</creatorcontrib><creatorcontrib>Kotloff, Karen</creatorcontrib><creatorcontrib>Zangwill, Ken</creatorcontrib><creatorcontrib>Iacuzio, Dominick</creatorcontrib><creatorcontrib>Wolff, Mark</creatorcontrib><title>The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Influenza A and B viruses are among the most common causes of respiratory tract illnesses that bring children to medical care, and influenza is a major cause of lower respiratory tract illness in young children.
1
The annual incidence of influenza infection in children may exceed 30 percent,
2
and children are believed to be important in the spread of influenza in the community.
3
Despite the availability of inactivated influenzavirus vaccine for children, the vaccine is used infrequently in this age group.
4
Live attenuated, cold-adapted, trivalent influenzavirus vaccine that is given intranasally may represent a convenient and effective approach to the prevention . . .</description><subject>Administration, Intranasal</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Double-Blind Method</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>Fever - etiology</subject><subject>Fever - prevention & control</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Influenza A virus - immunology</subject><subject>Influenza B virus - immunology</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - adverse effects</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Otitis Media - prevention & control</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><subject>Vaccines</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - adverse effects</subject><subject>Vaccines, Attenuated - immunology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtvEzEQxy0EKqHwCRDSCiEudMHvxzGKAhQFuASuK9ceU0e73tTejVQ-PS6JekAIfJnXb2Y0_iP0nOC3BAv57sv602dijMaCcMY0xZg-QAsiGGs5x_IhWtSMbrky7DF6UsoO10e4OUNnRmgsuVqgH9traNYhRGfdbTOGZhMP0CynCdJsJ_AXzWrsfbv0dv872uZ4sD2k6aK5TFO2yRbbVzf0M6Sf9hDzXJrv1rmYoImpWV3H3mdIT9GjYPsCz072HH17v96uPrabrx8uV8tN6yQVU-s114IJbQ2RyhplrwQAVk5R7T0ErzFnhlSPKukUwcExza0HKXGNgLFz9Po4d5_HmxnK1A2xOOh7m2CcS6eMZtxI81-QSI4Jo7iCL_8Ad-OcUz2io5QZLrQmFWJHyOWxlAyh2-c42HzbEdzdidX9Raza9eI0er4awN_3nNSp9Venui3O9qF-t4vlHqOUGk7vlr85YsNQugS74Z9LfwEPQKaR</recordid><startdate>19980514</startdate><enddate>19980514</enddate><creator>Belshe, Robert B</creator><creator>Mendelman, Paul M</creator><creator>Treanor, John</creator><creator>King, James</creator><creator>Gruber, William C</creator><creator>Piedra, Pedro</creator><creator>Bernstein, David I</creator><creator>Hayden, Frederick G</creator><creator>Kotloff, Karen</creator><creator>Zangwill, Ken</creator><creator>Iacuzio, Dominick</creator><creator>Wolff, Mark</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980514</creationdate><title>The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children</title><author>Belshe, Robert B ; Mendelman, Paul M ; Treanor, John ; King, James ; Gruber, William C ; Piedra, Pedro ; Bernstein, David I ; Hayden, Frederick G ; Kotloff, Karen ; Zangwill, Ken ; Iacuzio, Dominick ; Wolff, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-d8485358a9167a97ab5ee07c728ddefd804391def276c710fc384ade660710e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Intranasal</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Double-Blind Method</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>Fever - etiology</topic><topic>Fever - prevention & control</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Influenza A virus - immunology</topic><topic>Influenza B virus - immunology</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - adverse effects</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza, Human - immunology</topic><topic>Influenza, Human - prevention & control</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Otitis Media - prevention & control</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><topic>Vaccines</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - adverse effects</topic><topic>Vaccines, Attenuated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belshe, Robert B</creatorcontrib><creatorcontrib>Mendelman, Paul M</creatorcontrib><creatorcontrib>Treanor, John</creatorcontrib><creatorcontrib>King, James</creatorcontrib><creatorcontrib>Gruber, William C</creatorcontrib><creatorcontrib>Piedra, Pedro</creatorcontrib><creatorcontrib>Bernstein, David I</creatorcontrib><creatorcontrib>Hayden, Frederick G</creatorcontrib><creatorcontrib>Kotloff, Karen</creatorcontrib><creatorcontrib>Zangwill, Ken</creatorcontrib><creatorcontrib>Iacuzio, Dominick</creatorcontrib><creatorcontrib>Wolff, Mark</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belshe, Robert B</au><au>Mendelman, Paul M</au><au>Treanor, John</au><au>King, James</au><au>Gruber, William C</au><au>Piedra, Pedro</au><au>Bernstein, David I</au><au>Hayden, Frederick G</au><au>Kotloff, Karen</au><au>Zangwill, Ken</au><au>Iacuzio, Dominick</au><au>Wolff, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1998-05-14</date><risdate>1998</risdate><volume>338</volume><issue>20</issue><spage>1405</spage><epage>1412</epage><pages>1405-1412</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Influenza A and B viruses are among the most common causes of respiratory tract illnesses that bring children to medical care, and influenza is a major cause of lower respiratory tract illness in young children.
1
The annual incidence of influenza infection in children may exceed 30 percent,
2
and children are believed to be important in the spread of influenza in the community.
3
Despite the availability of inactivated influenzavirus vaccine for children, the vaccine is used infrequently in this age group.
4
Live attenuated, cold-adapted, trivalent influenzavirus vaccine that is given intranasally may represent a convenient and effective approach to the prevention . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9580647</pmid><doi>10.1056/NEJM199805143382002</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-05, Vol.338 (20), p.1405-1412 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79834969 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Administration, Intranasal Antibodies, Viral - blood Biological and medical sciences Child, Preschool Children & youth Double-Blind Method Epidemiology. Vaccinations Female Fever - etiology Fever - prevention & control General aspects Humans Infant Infectious diseases Influenza Influenza A virus - immunology Influenza B virus - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Male Medical research Medical sciences Otitis Media - prevention & control Prospective Studies Treatment Outcome Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology |
| title | The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children |
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