Influence of Captopril on Urinary Excretion of Furosemide in Hypertensive Subjects
Influence of captopril on urinary excretion of furosemide was examined in a placebo‐controlled, crossover design. Furosemide (20 mg) was injected intravenously in eight hypertensive subjects with pretreatment with captopril (25 mg) or matching placebo. Urine samples for furosemide and sodium were co...
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| Veröffentlicht in: | Journal of clinical pharmacology 1990-06, Vol.30 (6), p.538-542 |
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| creator | Fujimura, Akio Shimokawa, Yoji Ebihara, Akio |
| description | Influence of captopril on urinary excretion of furosemide was examined in a placebo‐controlled, crossover design. Furosemide (20 mg) was injected intravenously in eight hypertensive subjects with pretreatment with captopril (25 mg) or matching placebo. Urine samples for furosemide and sodium were collected during the following intervals: −60 ∼ 0, 0 ∼ 60, 60 ∼ 120, and 120 ∼ 180 minutes after furosemide. Blood samples for plasma renin activity (PRA) and angiotensin II (AII) were obtained, and blood pressure was measured at −60, 0, 60, 120, and 180 minutes after furosemide.
No significant difference was observed in urinary excretion of furosemide, volume or sodium between these trials. Although PRA increased following furosemide with captopril, as predicted plasma AII did not increase. Blood pressure significantly decreased following the combined therapy, but not furosemide alone.
These data indicate that the urinary excretion of furosemide and its subsequent diuretic effects are not influenced by captopril. |
| doi_str_mv | 10.1002/j.1552-4604.1990.tb03617.x |
| format | Article |
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No significant difference was observed in urinary excretion of furosemide, volume or sodium between these trials. Although PRA increased following furosemide with captopril, as predicted plasma AII did not increase. Blood pressure significantly decreased following the combined therapy, but not furosemide alone.
These data indicate that the urinary excretion of furosemide and its subsequent diuretic effects are not influenced by captopril.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1990.tb03617.x</identifier><identifier>PMID: 2191978</identifier><identifier>CODEN: JCPCBR</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Angiotensin II - blood ; Biological and medical sciences ; Captopril - pharmacology ; Drug Therapy, Combination ; Female ; Furosemide - administration & dosage ; Furosemide - urine ; Humans ; Hypertension - drug therapy ; Hypertension - urine ; Injections, Intravenous ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Premedication ; Random Allocation ; Renin - blood ; Time Factors ; Urinary system</subject><ispartof>Journal of clinical pharmacology, 1990-06, Vol.30 (6), p.538-542</ispartof><rights>1990 American College of Clinical Pharmacology</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3827-33544289192435a52eb7316c31d72709564f2e9d5b45b1c99c62029d7e0356e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1552-4604.1990.tb03617.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1552-4604.1990.tb03617.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19269643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2191978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujimura, Akio</creatorcontrib><creatorcontrib>Shimokawa, Yoji</creatorcontrib><creatorcontrib>Ebihara, Akio</creatorcontrib><title>Influence of Captopril on Urinary Excretion of Furosemide in Hypertensive Subjects</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>Influence of captopril on urinary excretion of furosemide was examined in a placebo‐controlled, crossover design. Furosemide (20 mg) was injected intravenously in eight hypertensive subjects with pretreatment with captopril (25 mg) or matching placebo. Urine samples for furosemide and sodium were collected during the following intervals: −60 ∼ 0, 0 ∼ 60, 60 ∼ 120, and 120 ∼ 180 minutes after furosemide. Blood samples for plasma renin activity (PRA) and angiotensin II (AII) were obtained, and blood pressure was measured at −60, 0, 60, 120, and 180 minutes after furosemide.
No significant difference was observed in urinary excretion of furosemide, volume or sodium between these trials. Although PRA increased following furosemide with captopril, as predicted plasma AII did not increase. Blood pressure significantly decreased following the combined therapy, but not furosemide alone.
These data indicate that the urinary excretion of furosemide and its subsequent diuretic effects are not influenced by captopril.</description><subject>Adult</subject><subject>Aged</subject><subject>Angiotensin II - blood</subject><subject>Biological and medical sciences</subject><subject>Captopril - pharmacology</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Furosemide - administration & dosage</subject><subject>Furosemide - urine</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - urine</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Premedication</subject><subject>Random Allocation</subject><subject>Renin - blood</subject><subject>Time Factors</subject><subject>Urinary system</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF9v0zAUxS3ENMrgIyBFSOwtmf-75glUbeumCaaNqYgXy3FuJJc0KXYy2m8_R43KM0--8j333HN_CH0kuCAY04t1QYSgOZeYF0RrXPQlZpKoYvcKzY6t12iGsSY5VRi_QW9jXGNMJBfkFJ1SoolW8xl6uGnrZoDWQdbV2cJu-24bfJN1bfYUfGvDPrvcuQC9Tz9JcTWELsLGV5D5NlvutxB6aKN_huxxKNfg-vgOndS2ifB-es_Q09Xlj8Uyv_t-fbP4epc7NqcqZ0xwTucpB-VMWEGhVIxIx0ilUmQtJK8p6EqUXJTEae0kxVRXCjATEhQ7Q-cH323o_gwQe7Px0UHT2Ba6IRql54xLpZPw80HoUvYYoDbpxE06zRBsRqBmbUZqZqRmRqBmAmp2afjDtGUoN1AdRyeCqf9p6tvobFMH2zof_23QVGrJWdJ9Oej--gb2_5HA3C7ul2OZLPKDhY897I4WNvw2UjElzOrbtVndP_ySK_7TPLIXiUWhIA</recordid><startdate>199006</startdate><enddate>199006</enddate><creator>Fujimura, Akio</creator><creator>Shimokawa, Yoji</creator><creator>Ebihara, Akio</creator><general>Blackwell Publishing Ltd</general><general>Sage Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199006</creationdate><title>Influence of Captopril on Urinary Excretion of Furosemide in Hypertensive Subjects</title><author>Fujimura, Akio ; Shimokawa, Yoji ; Ebihara, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3827-33544289192435a52eb7316c31d72709564f2e9d5b45b1c99c62029d7e0356e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angiotensin II - blood</topic><topic>Biological and medical sciences</topic><topic>Captopril - pharmacology</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Furosemide - administration & dosage</topic><topic>Furosemide - urine</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - urine</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Premedication</topic><topic>Random Allocation</topic><topic>Renin - blood</topic><topic>Time Factors</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujimura, Akio</creatorcontrib><creatorcontrib>Shimokawa, Yoji</creatorcontrib><creatorcontrib>Ebihara, Akio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujimura, Akio</au><au>Shimokawa, Yoji</au><au>Ebihara, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Captopril on Urinary Excretion of Furosemide in Hypertensive Subjects</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1990-06</date><risdate>1990</risdate><volume>30</volume><issue>6</issue><spage>538</spage><epage>542</epage><pages>538-542</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><coden>JCPCBR</coden><abstract>Influence of captopril on urinary excretion of furosemide was examined in a placebo‐controlled, crossover design. Furosemide (20 mg) was injected intravenously in eight hypertensive subjects with pretreatment with captopril (25 mg) or matching placebo. Urine samples for furosemide and sodium were collected during the following intervals: −60 ∼ 0, 0 ∼ 60, 60 ∼ 120, and 120 ∼ 180 minutes after furosemide. Blood samples for plasma renin activity (PRA) and angiotensin II (AII) were obtained, and blood pressure was measured at −60, 0, 60, 120, and 180 minutes after furosemide.
No significant difference was observed in urinary excretion of furosemide, volume or sodium between these trials. Although PRA increased following furosemide with captopril, as predicted plasma AII did not increase. Blood pressure significantly decreased following the combined therapy, but not furosemide alone.
These data indicate that the urinary excretion of furosemide and its subsequent diuretic effects are not influenced by captopril.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2191978</pmid><doi>10.1002/j.1552-4604.1990.tb03617.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Angiotensin II - blood Biological and medical sciences Captopril - pharmacology Drug Therapy, Combination Female Furosemide - administration & dosage Furosemide - urine Humans Hypertension - drug therapy Hypertension - urine Injections, Intravenous Male Medical sciences Middle Aged Pharmacology. Drug treatments Premedication Random Allocation Renin - blood Time Factors Urinary system |
| title | Influence of Captopril on Urinary Excretion of Furosemide in Hypertensive Subjects |
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