The adenosine antagonist 8-cyclopentyltheophylline reduces the depression of hippocampal neuronal responses during hypoxia

Exposure of rat hippocampal slices to hypoxic conditions for 15 min produced a rapid, but completely reversible depression of evoked synaptic potentials. The specific A 1 adenosine receptor antagonist 8-cyclopentyltheophyline (8-CPT) significantly reduced hypoxia-induced synaptic depression in conce...

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Veröffentlicht in:	Brain research 1990-04, Vol.512 (2), p.353-357
Hauptverfasser:	Gribkoff, Valentin K., Bauman, Lisa A., VanderMaelen, Cam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Cylopentyltheophylline Action Potentials - drug effects Adenosine antagonist Animals Biological and medical sciences Central nervous system Electrophysiology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - physiopathology Hypoxia Hypoxia, Brain - metabolism Hypoxia, Brain - physiopathology In Vitro Techniques Purinergic Antagonists Rats Receptors, Purinergic - physiology Synaptic depression Theophylline - analogs & derivatives Theophylline - pharmacology Vertebrates: nervous system and sense organs
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