Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes

The effects of enzyme induction on the generation of cytotoxic metabolites from phenytoin, mianserin, imipramine, desipramine and amitriptyline by mouse liver microsomes has been investigated and then compared with the bioactivation mediated by human hepatic microsomes. Cytotoxicity was assessed by...

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Veröffentlicht in:	Biochemical pharmacology 1990-06, Vol.39 (12), p.1951-1958
Hauptverfasser:	Riley, R.J., Roberts, P., Kitteringham, N.R., Park, B.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Alkoxycoumarin O-Dealkylase - metabolism amitriptyline Amitriptyline - metabolism Amitriptyline - pharmacokinetics Animals Benzoflavones - pharmacology beta-Naphthoflavone Biological and medical sciences Biotransformation desipramine Desipramine - metabolism Desipramine - pharmacokinetics Dibenzoxazepines - metabolism Drug toxicity and drugs side effects treatment endoplasmic reticulum Enzyme Induction - drug effects Humans imipramine Imipramine - metabolism Imipramine - pharmacokinetics Injections, Intraperitoneal Male Medical sciences mianserin Mianserin - metabolism Mianserin - pharmacokinetics Mice Mice, Inbred CBA microsomes Microsomes, Liver - drug effects Microsomes, Liver - metabolism Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Phenobarbital - pharmacology Phenytoin - metabolism Phenytoin - pharmacokinetics
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