IL-10 Regulates Liver Pathology in Acute Murine Schistosomiasis mansoni But Is Not Required for Immune Down-Modulation of Chronic Disease

We have used IL-10 gene knockout mice (IL-10T) to examine the role of endogenous IL-10 in the down-modulation of hepatic granuloma formation and lymphocyte responses that occurs in chronic infection with the helminth parasite Schistosoma mansoni. Although IL-10-deficient animals showed 20 to 30% mor...

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