Cerebrospinal Fluid Cachectin/Tumor Necrosis Factor-α and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children
In prospective studies, tumor necrosis factor (TNFα) was detected in cerebrospinal fluid (CSF) of 33 of 38 children with bacterial meningitis (BM) but in none of 15 with viral meningitisZencephalitis P < .001). BM CSF TNFα (25,500 pgZml) correlated with CSF bacterial density (P < .01), CSF pro...
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| Veröffentlicht in: | The Journal of infectious diseases 1990-07, Vol.162 (1), p.139-147 |
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| creator | Arditi, Moshe Manogue, Kirk R. Caplan, Michael Yogev, Ram |
| description | In prospective studies, tumor necrosis factor (TNFα) was detected in cerebrospinal fluid (CSF) of 33 of 38 children with bacterial meningitis (BM) but in none of 15 with viral meningitisZencephalitis P < .001). BM CSF TNFα (25,500 pgZml) correlated with CSF bacterial density (P < .01), CSF protein (P < .001), endotoxin (LPS) in gram-negative disease (P < .01), and consecutive febrile hospital days (P < .001); initial CSF TNFα >1000 pgZml was associated with seizures (P < .05). Only 5 children with BM (13%) had detectable plasma TNFa activity on admission. A higher proportion who died had detectable plasma TNFa activity compared with survivors (3/4 vs. 2/34, P < .005). Platelet-activating factor (PAF) in CSF was higher in 19 children with Haemophilus influenzae meningitis than in 17 controls (P < .01) and correlated with bacterial density (P < .01), CSF LPS (P < .01), CSF TNFa levels (P < .01), and the Herson-Todd severity score (P < .01). Elevated CSF TNFα and PAF are often present in children with BM and are associated with seizures and severity of disease. Detectable CSF TNFα appears to distinguish BM from viral meningitis. |
| doi_str_mv | 10.1093/infdis/162.1.139 |
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BM CSF TNFα (<35 to >25,500 pgZml) correlated with CSF bacterial density (P < .01), CSF protein (P < .001), endotoxin (LPS) in gram-negative disease (P < .01), and consecutive febrile hospital days (P < .001); initial CSF TNFα >1000 pgZml was associated with seizures (P < .05). Only 5 children with BM (13%) had detectable plasma TNFa activity on admission. A higher proportion who died had detectable plasma TNFa activity compared with survivors (3/4 vs. 2/34, P < .005). Platelet-activating factor (PAF) in CSF was higher in 19 children with Haemophilus influenzae meningitis than in 17 controls (P < .01) and correlated with bacterial density (P < .01), CSF LPS (P < .01), CSF TNFa levels (P < .01), and the Herson-Todd severity score (P < .01). Elevated CSF TNFα and PAF are often present in children with BM and are associated with seizures and severity of disease. Detectable CSF TNFα appears to distinguish BM from viral meningitis.]]></description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/162.1.139</identifier><identifier>PMID: 2355190</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Adolescent ; Antibiotics ; Bacteria - growth & development ; Bacterial diseases ; Bacterial meningitis ; Biological and medical sciences ; Cerebrospinal fluid ; Cerebrospinal Fluid - microbiology ; Cerebrospinal Fluid Proteins - cerebrospinal fluid ; Child ; Child, Preschool ; Children ; Endotoxins ; Endotoxins - cerebrospinal fluid ; Escherichia coli meningitis ; Haemophilus meningitis ; Humans ; Infant ; Infectious diseases ; Lipopolysaccharides - cerebrospinal fluid ; Major Articles ; Medical sciences ; Meningitis - cerebrospinal fluid ; Meningitis - complications ; Meningitis, Haemophilus - cerebrospinal fluid ; Meningitis, Haemophilus - complications ; Platelet Activating Factor - cerebrospinal fluid ; Pneumococcal meningitis ; Prospective Studies ; Seizures - etiology ; Tumor Necrosis Factor-alpha - cerebrospinal fluid ; Tumor necrosis factors ; Viral meningitis</subject><ispartof>The Journal of infectious diseases, 1990-07, Vol.162 (1), p.139-147</ispartof><rights>Copyright 1990 The University of Chicago</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30127854$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30127854$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5520868$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2355190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arditi, Moshe</creatorcontrib><creatorcontrib>Manogue, Kirk R.</creatorcontrib><creatorcontrib>Caplan, Michael</creatorcontrib><creatorcontrib>Yogev, Ram</creatorcontrib><title>Cerebrospinal Fluid Cachectin/Tumor Necrosis Factor-α and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description><![CDATA[In prospective studies, tumor necrosis factor (TNFα) was detected in cerebrospinal fluid (CSF) of 33 of 38 children with bacterial meningitis (BM) but in none of 15 with viral meningitisZencephalitis P < .001). BM CSF TNFα (<35 to >25,500 pgZml) correlated with CSF bacterial density (P < .01), CSF protein (P < .001), endotoxin (LPS) in gram-negative disease (P < .01), and consecutive febrile hospital days (P < .001); initial CSF TNFα >1000 pgZml was associated with seizures (P < .05). Only 5 children with BM (13%) had detectable plasma TNFa activity on admission. A higher proportion who died had detectable plasma TNFa activity compared with survivors (3/4 vs. 2/34, P < .005). Platelet-activating factor (PAF) in CSF was higher in 19 children with Haemophilus influenzae meningitis than in 17 controls (P < .01) and correlated with bacterial density (P < .01), CSF LPS (P < .01), CSF TNFa levels (P < .01), and the Herson-Todd severity score (P < .01). Elevated CSF TNFα and PAF are often present in children with BM and are associated with seizures and severity of disease. Detectable CSF TNFα appears to distinguish BM from viral meningitis.]]></description><subject>Adolescent</subject><subject>Antibiotics</subject><subject>Bacteria - growth & development</subject><subject>Bacterial diseases</subject><subject>Bacterial meningitis</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid</subject><subject>Cerebrospinal Fluid - microbiology</subject><subject>Cerebrospinal Fluid Proteins - cerebrospinal fluid</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Endotoxins</subject><subject>Endotoxins - cerebrospinal fluid</subject><subject>Escherichia coli meningitis</subject><subject>Haemophilus meningitis</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Lipopolysaccharides - cerebrospinal fluid</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Meningitis - cerebrospinal fluid</subject><subject>Meningitis - complications</subject><subject>Meningitis, Haemophilus - cerebrospinal fluid</subject><subject>Meningitis, Haemophilus - complications</subject><subject>Platelet Activating Factor - cerebrospinal fluid</subject><subject>Pneumococcal meningitis</subject><subject>Prospective Studies</subject><subject>Seizures - etiology</subject><subject>Tumor Necrosis Factor-alpha - cerebrospinal fluid</subject><subject>Tumor necrosis factors</subject><subject>Viral meningitis</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M2OFCEUBWBiNGPP6N6NCQvjrrqB21TBcqzYo8n4kziuOxTccujQVAvUJPMgPogv4jNJtDIuXRE4H-cml5AXnK0507DxcXQ-b3gr1nzNQT8iKy6ha9qWw2OyYkyIhiutn5LznA-MsS203Rk5EyAl12xFfvSYcEhTPvloAt2F2TvaG3uLtvi4uZmPU6If0VbhM90ZW6bU_PpJTXT0czAFA5bmsto7U_23RdB-ihZjSfVxivmP_oJ3mHy5p9NI31RVL3XgB4z1my-13Efa3_rgEsZn5MloQsbny3lBvu7e3vTvmutPV-_7y-vmIAQrTWtBS9YJx4UdB-4UKAUtKs3cMDhrQPNRaTWwbbtFBtp0fAAQA8qKUI9wQV7_7T2l6fuMueyPPlsMwUSc5rzvtALoBP8v5FJrXTda4csFzsMR3f6U_NGk-_2y8Jq_WnKTrQljMtH6_MCkFEy16l_NIdd1PsTAuOiU3MJv8N-ckg</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Arditi, Moshe</creator><creator>Manogue, Kirk R.</creator><creator>Caplan, Michael</creator><creator>Yogev, Ram</creator><general>University of Chicago Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>Cerebrospinal Fluid Cachectin/Tumor Necrosis Factor-α and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children</title><author>Arditi, Moshe ; Manogue, Kirk R. ; Caplan, Michael ; Yogev, Ram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j220t-6c395072d12cfb1d838836e890dbbdca391f898b0464e039a71b332be56e8e9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Antibiotics</topic><topic>Bacteria - growth & development</topic><topic>Bacterial diseases</topic><topic>Bacterial meningitis</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid</topic><topic>Cerebrospinal Fluid - microbiology</topic><topic>Cerebrospinal Fluid Proteins - cerebrospinal fluid</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Endotoxins</topic><topic>Endotoxins - cerebrospinal fluid</topic><topic>Escherichia coli meningitis</topic><topic>Haemophilus meningitis</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Lipopolysaccharides - cerebrospinal fluid</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Meningitis - cerebrospinal fluid</topic><topic>Meningitis - complications</topic><topic>Meningitis, Haemophilus - cerebrospinal fluid</topic><topic>Meningitis, Haemophilus - complications</topic><topic>Platelet Activating Factor - cerebrospinal fluid</topic><topic>Pneumococcal meningitis</topic><topic>Prospective Studies</topic><topic>Seizures - etiology</topic><topic>Tumor Necrosis Factor-alpha - cerebrospinal fluid</topic><topic>Tumor necrosis factors</topic><topic>Viral meningitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arditi, Moshe</creatorcontrib><creatorcontrib>Manogue, Kirk R.</creatorcontrib><creatorcontrib>Caplan, Michael</creatorcontrib><creatorcontrib>Yogev, Ram</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arditi, Moshe</au><au>Manogue, Kirk R.</au><au>Caplan, Michael</au><au>Yogev, Ram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal Fluid Cachectin/Tumor Necrosis Factor-α and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>162</volume><issue>1</issue><spage>139</spage><epage>147</epage><pages>139-147</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract><![CDATA[In prospective studies, tumor necrosis factor (TNFα) was detected in cerebrospinal fluid (CSF) of 33 of 38 children with bacterial meningitis (BM) but in none of 15 with viral meningitisZencephalitis P < .001). BM CSF TNFα (<35 to >25,500 pgZml) correlated with CSF bacterial density (P < .01), CSF protein (P < .001), endotoxin (LPS) in gram-negative disease (P < .01), and consecutive febrile hospital days (P < .001); initial CSF TNFα >1000 pgZml was associated with seizures (P < .05). Only 5 children with BM (13%) had detectable plasma TNFa activity on admission. A higher proportion who died had detectable plasma TNFa activity compared with survivors (3/4 vs. 2/34, P < .005). Platelet-activating factor (PAF) in CSF was higher in 19 children with Haemophilus influenzae meningitis than in 17 controls (P < .01) and correlated with bacterial density (P < .01), CSF LPS (P < .01), CSF TNFa levels (P < .01), and the Herson-Todd severity score (P < .01). Elevated CSF TNFα and PAF are often present in children with BM and are associated with seizures and severity of disease. Detectable CSF TNFα appears to distinguish BM from viral meningitis.]]></abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>2355190</pmid><doi>10.1093/infdis/162.1.139</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adolescent Antibiotics Bacteria - growth & development Bacterial diseases Bacterial meningitis Biological and medical sciences Cerebrospinal fluid Cerebrospinal Fluid - microbiology Cerebrospinal Fluid Proteins - cerebrospinal fluid Child Child, Preschool Children Endotoxins Endotoxins - cerebrospinal fluid Escherichia coli meningitis Haemophilus meningitis Humans Infant Infectious diseases Lipopolysaccharides - cerebrospinal fluid Major Articles Medical sciences Meningitis - cerebrospinal fluid Meningitis - complications Meningitis, Haemophilus - cerebrospinal fluid Meningitis, Haemophilus - complications Platelet Activating Factor - cerebrospinal fluid Pneumococcal meningitis Prospective Studies Seizures - etiology Tumor Necrosis Factor-alpha - cerebrospinal fluid Tumor necrosis factors Viral meningitis |
| title | Cerebrospinal Fluid Cachectin/Tumor Necrosis Factor-α and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children |
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