Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression
Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no...
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| Veröffentlicht in: | Cancer 1990-07, Vol.66 (1), p.162-166 |
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| container_title | Cancer |
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| creator | Standen, Graham R. Jasani, Bharat Wagstaff, Michael Wardrop, Charles A. J. |
| description | Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed. |
| doi_str_mv | 10.1002/1097-0142(19900701)66:1<162::AID-CNCR2820660129>3.0.CO;2-Z |
| format | Article |
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Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19900701)66:1<162::AID-CNCR2820660129>3.0.CO;2-Z</identifier><identifier>PMID: 2112978</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Female ; Hematologic and hematopoietic diseases ; Humans ; Immunoglobulin lambda-Chains - immunology ; Immunoglobulin Light Chains - immunology ; Immunohistochemistry ; Leukemia, Neutrophilic, Chronic - complications ; Leukemia, Neutrophilic, Chronic - immunology ; Leukemia, Neutrophilic, Chronic - metabolism ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Multiple Myeloma - complications ; Multiple Myeloma - immunology ; Multiple Myeloma - metabolism ; Paraproteinemias - complications</subject><ispartof>Cancer, 1990-07, Vol.66 (1), p.162-166</ispartof><rights>Copyright © 1990 American Cancer Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4969-179b2ca620c6b72f995e7bb8ee780dbd47c11735e268b258c7c287ea5ade7c983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19619233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2112978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Standen, Graham R.</creatorcontrib><creatorcontrib>Jasani, Bharat</creatorcontrib><creatorcontrib>Wagstaff, Michael</creatorcontrib><creatorcontrib>Wardrop, Charles A. J.</creatorcontrib><title>Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoglobulin lambda-Chains - immunology</subject><subject>Immunoglobulin Light Chains - immunology</subject><subject>Immunohistochemistry</subject><subject>Leukemia, Neutrophilic, Chronic - complications</subject><subject>Leukemia, Neutrophilic, Chronic - immunology</subject><subject>Leukemia, Neutrophilic, Chronic - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Multiple Myeloma - complications</subject><subject>Multiple Myeloma - immunology</subject><subject>Multiple Myeloma - metabolism</subject><subject>Paraproteinemias - complications</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNmKE0EUhgtRxszoIwh1ozgXHWtJ15IRIbbbwGBAFCQ3RXX1iV1avdjVzZhn8x18JiskjuiF4NXh8C_8fAg9p2ROCWFPKNEyI3TBHlOtCZGEnguxpE-pYMvl6vJFVrwt3jHFiBCEMv2Mz8m8WF-wbHMLzW7Ct9GMEKKyfME_3kWnMX5Or2Q5P0EnjKacVDNki3roWu9wC9M4dH3tQ3oCTF-g8RbbtsLNFEbfB8DNDkLX2CVetdjG2DlvR9-1-NqPNf7xHQf_qR6xq61vMXzrB4gxyffQna0NEe4f7xn68Orl--JNdrV-fVmsrjK30EJnVOqSOSsYcaKUbKt1DrIsFYBUpCqrhXSUSp4DE6pkuXLSMSXB5rYC6bTiZ-jRobcfuq8TxNE0PjoIwbbQTdHI5OGMyWTcHIxu6GIcYGv6wTd22BlKzJ6_2SM0e4TmF38jhKEm8Tcm8Td_8jfcEFOsDTObVP7guGIqG6huqo_Ak_7wqNvobNgOtnU-_l6gBdWM8-SDg-_aB9j918J_DvxL4T8Bnxexaw</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Standen, Graham R.</creator><creator>Jasani, Bharat</creator><creator>Wagstaff, Michael</creator><creator>Wardrop, Charles A. 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J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4969-179b2ca620c6b72f995e7bb8ee780dbd47c11735e268b258c7c287ea5ade7c983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoglobulin lambda-Chains - immunology</topic><topic>Immunoglobulin Light Chains - immunology</topic><topic>Immunohistochemistry</topic><topic>Leukemia, Neutrophilic, Chronic - complications</topic><topic>Leukemia, Neutrophilic, Chronic - immunology</topic><topic>Leukemia, Neutrophilic, Chronic - metabolism</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Multiple Myeloma - complications</topic><topic>Multiple Myeloma - immunology</topic><topic>Multiple Myeloma - metabolism</topic><topic>Paraproteinemias - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Standen, Graham R.</creatorcontrib><creatorcontrib>Jasani, Bharat</creatorcontrib><creatorcontrib>Wagstaff, Michael</creatorcontrib><creatorcontrib>Wardrop, Charles A. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Standen, Graham R.</au><au>Jasani, Bharat</au><au>Wagstaff, Michael</au><au>Wardrop, Charles A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>66</volume><issue>1</issue><spage>162</spage><epage>166</epage><pages>162-166</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2112978</pmid><doi>10.1002/1097-0142(19900701)66:1<162::AID-CNCR2820660129>3.0.CO;2-Z</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1990-07, Vol.66 (1), p.162-166 |
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| language | eng |
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| subjects | Aged Biological and medical sciences Female Hematologic and hematopoietic diseases Humans Immunoglobulin lambda-Chains - immunology Immunoglobulin Light Chains - immunology Immunohistochemistry Leukemia, Neutrophilic, Chronic - complications Leukemia, Neutrophilic, Chronic - immunology Leukemia, Neutrophilic, Chronic - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Multiple Myeloma - complications Multiple Myeloma - immunology Multiple Myeloma - metabolism Paraproteinemias - complications |
| title | Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression |
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