The Ability of Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor to Protect Neonatal Rats from Septic Death Due to Staphylococcus aureus
Granulocyte-macrophage colony-stimulating factor (GM-CSF) potentiates in vitro and in vivo production of granulocytes. Also, recombinant human GM-CSF in vitro enhances functional capabilities of human granulocytes. Recombinant murine (rm) GM-CSF was administered to neonatal rats in vivo to test its...
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| Veröffentlicht in: | The Journal of infectious diseases 1990-07, Vol.162 (1), p.109-114 |
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| container_title | The Journal of infectious diseases |
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| creator | Frenck, R. w. Sarman, G. Harper, T. E. Buescher, E. S. |
| description | Granulocyte-macrophage colony-stimulating factor (GM-CSF) potentiates in vitro and in vivo production of granulocytes. Also, recombinant human GM-CSF in vitro enhances functional capabilities of human granulocytes. Recombinant murine (rm) GM-CSF was administered to neonatal rats in vivo to test its ability to protect from septic death due to Staphylococcus aureus. When rmGM-CSF was given intraperitoneally 6 h beforea 90% lethal dose challenge of S. aureus, peak survival was observed at a dose of 30 pg/g (54% vs. 10% in animals administered saline; P < .001). Blood cultures were positive for S. aureus in 26 of 32 saline-treated and in 5 of 31 rmGM-CSF-treated animals (P < .001). Numbers of blood granulocytes were significantly increased 9 h after administration of rmGM-CSF (30 pg/g) but returned to control levels by 12 h. Neither neutrophil storage nor proliferative pools were affected. Thus, rmGM-CSF significantly improved survival when given prophylactically in a neonatal rat model of infection. |
| doi_str_mv | 10.1093/infdis/162.1.109 |
| format | Article |
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Neither neutrophil storage nor proliferative pools were affected. Thus, rmGM-CSF significantly improved survival when given prophylactically in a neonatal rat model of infection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/162.1.109</identifier><identifier>PMID: 2192004</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Animals, Newborn ; Blood ; Body weight ; Bone marrow ; Colony stimulating factors ; Colony-Stimulating Factors - therapeutic use ; Disease Models, Animal ; Dosage ; Granulocyte-Macrophage Colony-Stimulating Factor ; Granulocytes ; Granulocytes - immunology ; Growth Substances - therapeutic use ; Infections ; Leukocyte Count ; Major Articles ; Neutropenia ; Neutrophils ; Neutrophils - immunology ; Rats ; Rats, Inbred Strains ; Recombinant Proteins - therapeutic use ; Sepsis ; Sepsis - prevention & control ; Staphylococcal Infections - prevention & control</subject><ispartof>The Journal of infectious diseases, 1990-07, Vol.162 (1), p.109-114</ispartof><rights>Copyright 1990 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-a52f7bcbac4ee4e70f594d538b03b5150c168932bfaacce39b6ae29eb2cef8463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30127849$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30127849$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2192004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frenck, R. w.</creatorcontrib><creatorcontrib>Sarman, G.</creatorcontrib><creatorcontrib>Harper, T. E.</creatorcontrib><creatorcontrib>Buescher, E. S.</creatorcontrib><title>The Ability of Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor to Protect Neonatal Rats from Septic Death Due to Staphylococcus aureus</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Granulocyte-macrophage colony-stimulating factor (GM-CSF) potentiates in vitro and in vivo production of granulocytes. Also, recombinant human GM-CSF in vitro enhances functional capabilities of human granulocytes. Recombinant murine (rm) GM-CSF was administered to neonatal rats in vivo to test its ability to protect from septic death due to Staphylococcus aureus. When rmGM-CSF was given intraperitoneally 6 h beforea 90% lethal dose challenge of S. aureus, peak survival was observed at a dose of 30 pg/g (54% vs. 10% in animals administered saline; P < .001). Blood cultures were positive for S. aureus in 26 of 32 saline-treated and in 5 of 31 rmGM-CSF-treated animals (P < .001). Numbers of blood granulocytes were significantly increased 9 h after administration of rmGM-CSF (30 pg/g) but returned to control levels by 12 h. Neither neutrophil storage nor proliferative pools were affected. Thus, rmGM-CSF significantly improved survival when given prophylactically in a neonatal rat model of infection.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Blood</subject><subject>Body weight</subject><subject>Bone marrow</subject><subject>Colony stimulating factors</subject><subject>Colony-Stimulating Factors - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Dosage</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor</subject><subject>Granulocytes</subject><subject>Granulocytes - immunology</subject><subject>Growth Substances - therapeutic use</subject><subject>Infections</subject><subject>Leukocyte Count</subject><subject>Major Articles</subject><subject>Neutropenia</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Sepsis</subject><subject>Sepsis - prevention & control</subject><subject>Staphylococcal Infections - prevention & control</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUUtvEzEQthCohMCdC5JP3Lb1Y18-lpS2SGlBTZAQF2vszDYuu-vF9krkr_Br2ZAoHJFGGs18j5HmI-QtZ-ecKXnh-mbj4gUvxTnfb56RGS9klZUll8_JjDEhMl4r9ZK8ivGJMZbLsjojZ4IrMQ0z8nu9RXppXOvSjvqGPqD1nXE99InejcH1SG8C9GPr7S5hdgc2-GELj0gXvvX9Llsl140tJNc_0muwyQeaPP0SfEKb6D36HhK09AFSpE3wHV3hkJylVwhpS69G3NNXCYbtbrrhrR0jhTHgGF-TFw20Ed8c-5x8vf64Xtxmy883nxaXy8zKukgZFKKpjDVgc8QcK9YUKt8UsjZMmoIXzPKyVlKYBsBalMqUgEKhERabOi_lnLw_-A7B_xwxJt25aLFtoUc_Rl2pWgolqv8SecmmYmwisgNxelaMARs9BNdB2GnO9D43fchtUgjN_27m5N3RezQdbk6CY1D_8Kc4vfgES8ZFVed7fXbAXUz464RD-KHLSlaFvv32XddLtr7_UCnN5R_QibFG</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Frenck, R. w.</creator><creator>Sarman, G.</creator><creator>Harper, T. 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S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Ability of Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor to Protect Neonatal Rats from Septic Death Due to Staphylococcus aureus</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>162</volume><issue>1</issue><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Granulocyte-macrophage colony-stimulating factor (GM-CSF) potentiates in vitro and in vivo production of granulocytes. Also, recombinant human GM-CSF in vitro enhances functional capabilities of human granulocytes. Recombinant murine (rm) GM-CSF was administered to neonatal rats in vivo to test its ability to protect from septic death due to Staphylococcus aureus. When rmGM-CSF was given intraperitoneally 6 h beforea 90% lethal dose challenge of S. aureus, peak survival was observed at a dose of 30 pg/g (54% vs. 10% in animals administered saline; P < .001). Blood cultures were positive for S. aureus in 26 of 32 saline-treated and in 5 of 31 rmGM-CSF-treated animals (P < .001). Numbers of blood granulocytes were significantly increased 9 h after administration of rmGM-CSF (30 pg/g) but returned to control levels by 12 h. Neither neutrophil storage nor proliferative pools were affected. Thus, rmGM-CSF significantly improved survival when given prophylactically in a neonatal rat model of infection.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>2192004</pmid><doi>10.1093/infdis/162.1.109</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Animals, Newborn Blood Body weight Bone marrow Colony stimulating factors Colony-Stimulating Factors - therapeutic use Disease Models, Animal Dosage Granulocyte-Macrophage Colony-Stimulating Factor Granulocytes Granulocytes - immunology Growth Substances - therapeutic use Infections Leukocyte Count Major Articles Neutropenia Neutrophils Neutrophils - immunology Rats Rats, Inbred Strains Recombinant Proteins - therapeutic use Sepsis Sepsis - prevention & control Staphylococcal Infections - prevention & control |
| title | The Ability of Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor to Protect Neonatal Rats from Septic Death Due to Staphylococcus aureus |
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