Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives
In this paper, the use of ferrocene-based “electrochemically ionizable” derivatives to enhance ES-MS analysis of simple alcohols, sterols, and phenols is discussed. These derivatives are designed to take advantage of the electrolysis process inherent to operation of the ES ion source for selective i...
Gespeichert in:
| Veröffentlicht in: | Analytical chemistry (Washington) 1998-04, Vol.70 (8), p.1544-1554 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1554 |
|---|---|
| container_issue | 8 |
| container_start_page | 1544 |
| container_title | Analytical chemistry (Washington) |
| container_volume | 70 |
| creator | Van Berkel, Gary J Quirke, J. Martin E Tigani, Rudolfo A Dilley, Anja S Covey, Thomas R |
| description | In this paper, the use of ferrocene-based “electrochemically ionizable” derivatives to enhance ES-MS analysis of simple alcohols, sterols, and phenols is discussed. These derivatives are designed to take advantage of the electrolysis process inherent to operation of the ES ion source for selective ionization. Derivatization procedures, electrochemical character of the derivatives, and the ES-MS operational parameters necessary to maximize electrochemical ionization and to enhance gas-phase detection are presented with reference to ferrocenecarbamate ester derivatives of a variety of alcohol standards, as well as the ferroceneboronate derivative of the diol, pinacol. Tandem mass spectrometric analysis of the derivatives (precursor and product ion spectra) is shown to provide derivative confirmation, enhanced detection, and additional analyte structure information. The utility of this derivatization approach for the selective detection of alcohols in complicated mixtures is demonstrated using a saw palmetto (Serenoa repens) fruit extract known to contain a variety of alcohols at low levels. |
| doi_str_mv | 10.1021/ac971348o |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79830633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>29580529</sourcerecordid><originalsourceid>FETCH-LOGICAL-a470t-d954de6e0f91ec63e922b61cb6f7777f02d6b75e6ce9907ca42058c6138bf0503</originalsourceid><addsrcrecordid>eNplkF1LHDEUhoO06LrtRX9AYSgq9GK2J8kkmVyW9Wthi4LWQm9CJnsGR-djm8yK6683uh-CDYRcPE9eznkJ-UJhRIHRH9ZpRXmWdztkQAWDVOY5-0AGAMBTpgD2yH4IdwCUApW7ZFcLqZXMBuT2GH31YPvqKd6uTcrOJyc1ut53Ye7tMpl07Yb9siEkV_NX2GDvl6OEjza2u8WmcrauN1-KGpNN-AOGT-RjaeuAn9fvkPw-Pbken6fTi7PJ-Oc0tZmCPp1pkc1QIpSaopMcNWOFpK6QpYqnBDaThRIoHWoNytmMgcidpDwvShDAh-RolTv33b8Fht40VXBY17bFbhGM0jkHyXkUv70T77qFb-NshlGVZ5JmNErfV5KLfQSPpZn7qrF-aSiYl-rNtvrofl0HLooGZ1tz3XXkB2tuQyyq9LZ1VdhqjDGRSRW1dKVVocfHLbb-3kSqhLm-vDJw-efveMqFuYn-4cq3Lryt8P94z238pt0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217846141</pqid></control><display><type>article</type><title>Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Van Berkel, Gary J ; Quirke, J. Martin E ; Tigani, Rudolfo A ; Dilley, Anja S ; Covey, Thomas R</creator><creatorcontrib>Van Berkel, Gary J ; Quirke, J. Martin E ; Tigani, Rudolfo A ; Dilley, Anja S ; Covey, Thomas R</creatorcontrib><description>In this paper, the use of ferrocene-based “electrochemically ionizable” derivatives to enhance ES-MS analysis of simple alcohols, sterols, and phenols is discussed. These derivatives are designed to take advantage of the electrolysis process inherent to operation of the ES ion source for selective ionization. Derivatization procedures, electrochemical character of the derivatives, and the ES-MS operational parameters necessary to maximize electrochemical ionization and to enhance gas-phase detection are presented with reference to ferrocenecarbamate ester derivatives of a variety of alcohol standards, as well as the ferroceneboronate derivative of the diol, pinacol. Tandem mass spectrometric analysis of the derivatives (precursor and product ion spectra) is shown to provide derivative confirmation, enhanced detection, and additional analyte structure information. The utility of this derivatization approach for the selective detection of alcohols in complicated mixtures is demonstrated using a saw palmetto (Serenoa repens) fruit extract known to contain a variety of alcohols at low levels.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac971348o</identifier><identifier>PMID: 9569764</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Alcohols - analysis ; Alcohols - chemistry ; Analytical chemistry ; Chemistry ; Electrochemistry ; Exact sciences and technology ; Ferrous Compounds - chemistry ; Ions ; Mass Spectrometry - methods ; Phenols - analysis ; Phenols - chemistry ; Plant Extracts - isolation & purification ; Plants, Medicinal ; Scientific imaging ; Spectrometric and optical methods ; Sterols - analysis ; Sterols - chemistry</subject><ispartof>Analytical chemistry (Washington), 1998-04, Vol.70 (8), p.1544-1554</ispartof><rights>Copyright © 1998 American Chemical Society</rights><rights>1998 INIST-CNRS</rights><rights>Copyright American Chemical Society Apr 15, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a470t-d954de6e0f91ec63e922b61cb6f7777f02d6b75e6ce9907ca42058c6138bf0503</citedby><cites>FETCH-LOGICAL-a470t-d954de6e0f91ec63e922b61cb6f7777f02d6b75e6ce9907ca42058c6138bf0503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac971348o$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac971348o$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2225467$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9569764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Berkel, Gary J</creatorcontrib><creatorcontrib>Quirke, J. Martin E</creatorcontrib><creatorcontrib>Tigani, Rudolfo A</creatorcontrib><creatorcontrib>Dilley, Anja S</creatorcontrib><creatorcontrib>Covey, Thomas R</creatorcontrib><title>Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>In this paper, the use of ferrocene-based “electrochemically ionizable” derivatives to enhance ES-MS analysis of simple alcohols, sterols, and phenols is discussed. These derivatives are designed to take advantage of the electrolysis process inherent to operation of the ES ion source for selective ionization. Derivatization procedures, electrochemical character of the derivatives, and the ES-MS operational parameters necessary to maximize electrochemical ionization and to enhance gas-phase detection are presented with reference to ferrocenecarbamate ester derivatives of a variety of alcohol standards, as well as the ferroceneboronate derivative of the diol, pinacol. Tandem mass spectrometric analysis of the derivatives (precursor and product ion spectra) is shown to provide derivative confirmation, enhanced detection, and additional analyte structure information. The utility of this derivatization approach for the selective detection of alcohols in complicated mixtures is demonstrated using a saw palmetto (Serenoa repens) fruit extract known to contain a variety of alcohols at low levels.</description><subject>Alcohols - analysis</subject><subject>Alcohols - chemistry</subject><subject>Analytical chemistry</subject><subject>Chemistry</subject><subject>Electrochemistry</subject><subject>Exact sciences and technology</subject><subject>Ferrous Compounds - chemistry</subject><subject>Ions</subject><subject>Mass Spectrometry - methods</subject><subject>Phenols - analysis</subject><subject>Phenols - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plants, Medicinal</subject><subject>Scientific imaging</subject><subject>Spectrometric and optical methods</subject><subject>Sterols - analysis</subject><subject>Sterols - chemistry</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkF1LHDEUhoO06LrtRX9AYSgq9GK2J8kkmVyW9Wthi4LWQm9CJnsGR-djm8yK6683uh-CDYRcPE9eznkJ-UJhRIHRH9ZpRXmWdztkQAWDVOY5-0AGAMBTpgD2yH4IdwCUApW7ZFcLqZXMBuT2GH31YPvqKd6uTcrOJyc1ut53Ye7tMpl07Yb9siEkV_NX2GDvl6OEjza2u8WmcrauN1-KGpNN-AOGT-RjaeuAn9fvkPw-Pbken6fTi7PJ-Oc0tZmCPp1pkc1QIpSaopMcNWOFpK6QpYqnBDaThRIoHWoNytmMgcidpDwvShDAh-RolTv33b8Fht40VXBY17bFbhGM0jkHyXkUv70T77qFb-NshlGVZ5JmNErfV5KLfQSPpZn7qrF-aSiYl-rNtvrofl0HLooGZ1tz3XXkB2tuQyyq9LZ1VdhqjDGRSRW1dKVVocfHLbb-3kSqhLm-vDJw-efveMqFuYn-4cq3Lryt8P94z238pt0</recordid><startdate>19980415</startdate><enddate>19980415</enddate><creator>Van Berkel, Gary J</creator><creator>Quirke, J. Martin E</creator><creator>Tigani, Rudolfo A</creator><creator>Dilley, Anja S</creator><creator>Covey, Thomas R</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980415</creationdate><title>Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives</title><author>Van Berkel, Gary J ; Quirke, J. Martin E ; Tigani, Rudolfo A ; Dilley, Anja S ; Covey, Thomas R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a470t-d954de6e0f91ec63e922b61cb6f7777f02d6b75e6ce9907ca42058c6138bf0503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alcohols - analysis</topic><topic>Alcohols - chemistry</topic><topic>Analytical chemistry</topic><topic>Chemistry</topic><topic>Electrochemistry</topic><topic>Exact sciences and technology</topic><topic>Ferrous Compounds - chemistry</topic><topic>Ions</topic><topic>Mass Spectrometry - methods</topic><topic>Phenols - analysis</topic><topic>Phenols - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plants, Medicinal</topic><topic>Scientific imaging</topic><topic>Spectrometric and optical methods</topic><topic>Sterols - analysis</topic><topic>Sterols - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Berkel, Gary J</creatorcontrib><creatorcontrib>Quirke, J. Martin E</creatorcontrib><creatorcontrib>Tigani, Rudolfo A</creatorcontrib><creatorcontrib>Dilley, Anja S</creatorcontrib><creatorcontrib>Covey, Thomas R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Berkel, Gary J</au><au>Quirke, J. Martin E</au><au>Tigani, Rudolfo A</au><au>Dilley, Anja S</au><au>Covey, Thomas R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>1998-04-15</date><risdate>1998</risdate><volume>70</volume><issue>8</issue><spage>1544</spage><epage>1554</epage><pages>1544-1554</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>In this paper, the use of ferrocene-based “electrochemically ionizable” derivatives to enhance ES-MS analysis of simple alcohols, sterols, and phenols is discussed. These derivatives are designed to take advantage of the electrolysis process inherent to operation of the ES ion source for selective ionization. Derivatization procedures, electrochemical character of the derivatives, and the ES-MS operational parameters necessary to maximize electrochemical ionization and to enhance gas-phase detection are presented with reference to ferrocenecarbamate ester derivatives of a variety of alcohol standards, as well as the ferroceneboronate derivative of the diol, pinacol. Tandem mass spectrometric analysis of the derivatives (precursor and product ion spectra) is shown to provide derivative confirmation, enhanced detection, and additional analyte structure information. The utility of this derivatization approach for the selective detection of alcohols in complicated mixtures is demonstrated using a saw palmetto (Serenoa repens) fruit extract known to contain a variety of alcohols at low levels.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>9569764</pmid><doi>10.1021/ac971348o</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2700 |
| ispartof | Analytical chemistry (Washington), 1998-04, Vol.70 (8), p.1544-1554 |
| issn | 0003-2700 1520-6882 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79830633 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Alcohols - analysis Alcohols - chemistry Analytical chemistry Chemistry Electrochemistry Exact sciences and technology Ferrous Compounds - chemistry Ions Mass Spectrometry - methods Phenols - analysis Phenols - chemistry Plant Extracts - isolation & purification Plants, Medicinal Scientific imaging Spectrometric and optical methods Sterols - analysis Sterols - chemistry |
| title | Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T05%3A03%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Derivatization%20for%20Electrospray%20Ionization%20Mass%20Spectrometry.%203.%20Electrochemically%20Ionizable%20Derivatives&rft.jtitle=Analytical%20chemistry%20(Washington)&rft.au=Van%20Berkel,%20Gary%20J&rft.date=1998-04-15&rft.volume=70&rft.issue=8&rft.spage=1544&rft.epage=1554&rft.pages=1544-1554&rft.issn=0003-2700&rft.eissn=1520-6882&rft.coden=ANCHAM&rft_id=info:doi/10.1021/ac971348o&rft_dat=%3Cproquest_cross%3E29580529%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217846141&rft_id=info:pmid/9569764&rfr_iscdi=true |