Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

IL-12p70, a 70- to 75-kDa heterodimer consisting of disulfide-bonded 35-kDa (p35) and 40-kDa (p40) subunits, enhances Th1 development primarily by its ability to induce IFN-gamma production by NK and Th1 cells. Although homodimers of the p40 subunit of IL-12 are potent IL-12 receptor antagonists in...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-02, Vol.160 (3), p.1132-1138
Hauptverfasser:	Piccotti, Joseph R, Li, Kewang, Chan, Sherri Y, Ferrante, Jessica, Magram, Jeanne, Eichwald, Ernst J, Bishop, D. Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Cell Differentiation - genetics Cell Differentiation - immunology Cells, Cultured Concanavalin A - pharmacology Cytokines - biosynthesis Female Graft Rejection - genetics Graft Rejection - immunology Heart Transplantation - immunology Immunization Immunophenotyping Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-12 - deficiency Interleukin-12 - genetics Interleukin-12 - physiology Isoantigens - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mice, Nude Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - metabolism
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