EFFECTS OF MIDAZOLAM ON MEDIAN NERVE SOMATOSENSORY EVOKED POTENTIALS
We have studied the effect of i.v. midazolam on median nerve somatosensory evoked potentials (SSEP) in 10 unpremedicated adults. Anaesthesia was induced with midazolam by bolus administration (0.2 mg kg−1) followed by infusion (5 mg h−1). The latency and amplitudes of the SSEP responses over the sec...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1990-05, Vol.64 (5), p.590-593 |
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| creator | SLOAN, T.B. FUGINA, M.L. TOLEIKIS, J.R. |
| description | We have studied the effect of i.v. midazolam on median nerve somatosensory evoked potentials (SSEP) in 10 unpremedicated adults. Anaesthesia was induced with midazolam by bolus administration (0.2 mg kg−1) followed by infusion (5 mg h−1). The latency and amplitudes of the SSEP responses over the second cervical vertebrae (SC2) and sensory cortex (P17, N20, P25) were recorded before and for 10 min after induction. Data were analysed over that period for time-related alterations. Small but statistically significant increases in latency of the cortical N20 (P < 0.005) and P25 (P < 0.001) waves and interwave conduction times of SC2 to P25 (P < 0.005) and N20 to P25 (P < 0.021) were observed. Cortical amplitude (N20–P25) decreased significantly (P < 0.012), to approximately 60% of baseline. These results demonstrated that midazolam produced a depression of cortical SSEP amplitude without clinically significant alterations in latency. |
| doi_str_mv | 10.1093/bja/64.5.590 |
| format | Article |
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Anaesthesia was induced with midazolam by bolus administration (0.2 mg kg−1) followed by infusion (5 mg h−1). The latency and amplitudes of the SSEP responses over the second cervical vertebrae (SC2) and sensory cortex (P17, N20, P25) were recorded before and for 10 min after induction. Data were analysed over that period for time-related alterations. Small but statistically significant increases in latency of the cortical N20 (P < 0.005) and P25 (P < 0.001) waves and interwave conduction times of SC2 to P25 (P < 0.005) and N20 to P25 (P < 0.021) were observed. Cortical amplitude (N20–P25) decreased significantly (P < 0.012), to approximately 60% of baseline. These results demonstrated that midazolam produced a depression of cortical SSEP amplitude without clinically significant alterations in latency.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/64.5.590</identifier><identifier>PMID: 2354098</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Anesthesia, Intravenous ; benzodiazepines: midazolam ; Biological and medical sciences ; Cerebral Cortex - physiology ; Evoked Potentials, Somatosensory - drug effects ; Female ; Hemodynamics - drug effects ; Humans ; Hypnotics ; Hypnotics. Sedatives ; Male ; Median Nerve - drug effects ; Median Nerve - physiology ; Medical sciences ; Midazolam - pharmacology ; Middle Aged ; Monitoring: somatosensory evoked potentials ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Spinal Cord - physiology ; Time Factors</subject><ispartof>British journal of anaesthesia : BJA, 1990-05, Vol.64 (5), p.590-593</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-7e72e04552df842fcb79eacb9ffdab4a365a1aff78ea4d132817b58034b3dad43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19819724$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2354098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SLOAN, T.B.</creatorcontrib><creatorcontrib>FUGINA, M.L.</creatorcontrib><creatorcontrib>TOLEIKIS, J.R.</creatorcontrib><title>EFFECTS OF MIDAZOLAM ON MEDIAN NERVE SOMATOSENSORY EVOKED POTENTIALS</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>We have studied the effect of i.v. midazolam on median nerve somatosensory evoked potentials (SSEP) in 10 unpremedicated adults. Anaesthesia was induced with midazolam by bolus administration (0.2 mg kg−1) followed by infusion (5 mg h−1). The latency and amplitudes of the SSEP responses over the second cervical vertebrae (SC2) and sensory cortex (P17, N20, P25) were recorded before and for 10 min after induction. Data were analysed over that period for time-related alterations. Small but statistically significant increases in latency of the cortical N20 (P < 0.005) and P25 (P < 0.001) waves and interwave conduction times of SC2 to P25 (P < 0.005) and N20 to P25 (P < 0.021) were observed. Cortical amplitude (N20–P25) decreased significantly (P < 0.012), to approximately 60% of baseline. These results demonstrated that midazolam produced a depression of cortical SSEP amplitude without clinically significant alterations in latency.</description><subject>Adult</subject><subject>Anesthesia, Intravenous</subject><subject>benzodiazepines: midazolam</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - physiology</subject><subject>Evoked Potentials, Somatosensory - drug effects</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypnotics</subject><subject>Hypnotics. Sedatives</subject><subject>Male</subject><subject>Median Nerve - drug effects</subject><subject>Median Nerve - physiology</subject><subject>Medical sciences</subject><subject>Midazolam - pharmacology</subject><subject>Middle Aged</subject><subject>Monitoring: somatosensory evoked potentials</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Spinal Cord - physiology</subject><subject>Time Factors</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1v0zAYxi0EGmXsxhUpFziRzp9xfIxaZytr46kJFexiOY4tZfRj2C2C_55UrbYLp_fw_PQ8r34AfEBwjKAg1-2juc7omI2ZgK_ACFGO0oxz9BqMIIQ8hQLht-BdjI8QIo4FuwAXmDAKRT4CU1mWctLUiSqTxWxaPKh5sUhUlSzkdFZUSSWXK5nUalE0qpZVrZY_ErlSd3Ka3KtGVs2smNfvwRtv1tFdne8l-FbKZnKbztXNbFLMU0uJ2KfccewgZQx3PqfY25YLZ2wrvO9MSw3JmEHGe547QztEcI54y3JIaEs601FyCT6fep_C7tfBxb3e9NG69dps3e4QNRc5gZAewS8n0IZdjMF5_RT6jQl_NYL6KE0P0nRGNdODtAH_eO49tBvXPcNnS0P-6ZybaM3aB7O1fXzpFDkSHB9n0xPXx73785yb8FNnnHCmb78_6BIvyeoGfdVo4LMT7wZpv3sXdLS921rX9cHZve52_f8f_gcXopAG</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>SLOAN, T.B.</creator><creator>FUGINA, M.L.</creator><creator>TOLEIKIS, J.R.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900501</creationdate><title>EFFECTS OF MIDAZOLAM ON MEDIAN NERVE SOMATOSENSORY EVOKED POTENTIALS</title><author>SLOAN, T.B. ; FUGINA, M.L. ; TOLEIKIS, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-7e72e04552df842fcb79eacb9ffdab4a365a1aff78ea4d132817b58034b3dad43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Anesthesia, Intravenous</topic><topic>benzodiazepines: midazolam</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - physiology</topic><topic>Evoked Potentials, Somatosensory - drug effects</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypnotics</topic><topic>Hypnotics. Sedatives</topic><topic>Male</topic><topic>Median Nerve - drug effects</topic><topic>Median Nerve - physiology</topic><topic>Medical sciences</topic><topic>Midazolam - pharmacology</topic><topic>Middle Aged</topic><topic>Monitoring: somatosensory evoked potentials</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Spinal Cord - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SLOAN, T.B.</creatorcontrib><creatorcontrib>FUGINA, M.L.</creatorcontrib><creatorcontrib>TOLEIKIS, J.R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SLOAN, T.B.</au><au>FUGINA, M.L.</au><au>TOLEIKIS, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF MIDAZOLAM ON MEDIAN NERVE SOMATOSENSORY EVOKED POTENTIALS</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>64</volume><issue>5</issue><spage>590</spage><epage>593</epage><pages>590-593</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have studied the effect of i.v. midazolam on median nerve somatosensory evoked potentials (SSEP) in 10 unpremedicated adults. Anaesthesia was induced with midazolam by bolus administration (0.2 mg kg−1) followed by infusion (5 mg h−1). The latency and amplitudes of the SSEP responses over the second cervical vertebrae (SC2) and sensory cortex (P17, N20, P25) were recorded before and for 10 min after induction. Data were analysed over that period for time-related alterations. Small but statistically significant increases in latency of the cortical N20 (P < 0.005) and P25 (P < 0.001) waves and interwave conduction times of SC2 to P25 (P < 0.005) and N20 to P25 (P < 0.021) were observed. Cortical amplitude (N20–P25) decreased significantly (P < 0.012), to approximately 60% of baseline. These results demonstrated that midazolam produced a depression of cortical SSEP amplitude without clinically significant alterations in latency.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2354098</pmid><doi>10.1093/bja/64.5.590</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anesthesia, Intravenous benzodiazepines: midazolam Biological and medical sciences Cerebral Cortex - physiology Evoked Potentials, Somatosensory - drug effects Female Hemodynamics - drug effects Humans Hypnotics Hypnotics. Sedatives Male Median Nerve - drug effects Median Nerve - physiology Medical sciences Midazolam - pharmacology Middle Aged Monitoring: somatosensory evoked potentials Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Spinal Cord - physiology Time Factors |
| title | EFFECTS OF MIDAZOLAM ON MEDIAN NERVE SOMATOSENSORY EVOKED POTENTIALS |
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