Galectin-1 and -3 in cells of the first trimester placental bed
The beta-galactoside-binding proteins galectin-1 and -3 are thought to modulate cell-extracellular matrix interactions in cell adhesion and migration. In this study, their occurrence in human trophoblast has been investigated. In the first trimester placenta galectin-1 is expressed in the cytotropho...
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| Veröffentlicht in: | Human reproduction (Oxford) 1998-03, Vol.13 (3), p.730-735 |
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| creator | VIDOVAC, L JANKOVIC, M CUPERLOVIC, M |
| description | The beta-galactoside-binding proteins galectin-1 and -3 are thought to modulate cell-extracellular matrix interactions in cell adhesion and migration. In this study, their occurrence in human trophoblast has been investigated. In the first trimester placenta galectin-1 is expressed in the cytotrophoblast of the mid and distal cell columns, but absent from the villous and proximal column cytotrophoblast. The villous syncytiotrophoblast was also positive. Galectin-3, on the other hand, was uniformly localized in the villous cytotrophoblast and mid and distal cell columns. Immunolocalization of these proteins in placental bed tissue has shown that galectin-1 and -3 are not present in cytokeratin-positive interstitially migrating cytotrophoblast. The co-localization of galectin-1 with extracellular laminin in cultures of cytotrophoblast, choriocarcinoma or decidual stromal cells is consistent with a role in the organization of extracellular matrix and the regulation of cell motility. |
| doi_str_mv | 10.1093/humrep/13.3.730 |
| format | Article |
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In this study, their occurrence in human trophoblast has been investigated. In the first trimester placenta galectin-1 is expressed in the cytotrophoblast of the mid and distal cell columns, but absent from the villous and proximal column cytotrophoblast. The villous syncytiotrophoblast was also positive. Galectin-3, on the other hand, was uniformly localized in the villous cytotrophoblast and mid and distal cell columns. Immunolocalization of these proteins in placental bed tissue has shown that galectin-1 and -3 are not present in cytokeratin-positive interstitially migrating cytotrophoblast. The co-localization of galectin-1 with extracellular laminin in cultures of cytotrophoblast, choriocarcinoma or decidual stromal cells is consistent with a role in the organization of extracellular matrix and the regulation of cell motility.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/13.3.730</identifier><identifier>PMID: 9572443</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antigens, Differentiation - analysis ; Biological and medical sciences ; Cells, Cultured ; Decidua - chemistry ; Female ; Fundamental and applied biological sciences. Psychology ; Galectin 1 ; Galectin 3 ; Hemagglutinins - analysis ; Humans ; Immunohistochemistry ; Keratins - analysis ; Laminin - analysis ; Membrane Glycoproteins - analysis ; Mother. Fetoplacental unit. Mammary gland. Milk ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy. Parturition. Lactation ; Stromal Cells - chemistry ; Tissue Distribution ; Trophoblasts - chemistry ; Vertebrates: reproduction</subject><ispartof>Human reproduction (Oxford), 1998-03, Vol.13 (3), p.730-735</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b943a4ffc16ef0340d973a212c6a2b5898a306e86cbcda2049b4af06960a029e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2240173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9572443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VIDOVAC, L</creatorcontrib><creatorcontrib>JANKOVIC, M</creatorcontrib><creatorcontrib>CUPERLOVIC, M</creatorcontrib><title>Galectin-1 and -3 in cells of the first trimester placental bed</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><addtitle>Hum Reprod</addtitle><description>The beta-galactoside-binding proteins galectin-1 and -3 are thought to modulate cell-extracellular matrix interactions in cell adhesion and migration. In this study, their occurrence in human trophoblast has been investigated. In the first trimester placenta galectin-1 is expressed in the cytotrophoblast of the mid and distal cell columns, but absent from the villous and proximal column cytotrophoblast. The villous syncytiotrophoblast was also positive. Galectin-3, on the other hand, was uniformly localized in the villous cytotrophoblast and mid and distal cell columns. Immunolocalization of these proteins in placental bed tissue has shown that galectin-1 and -3 are not present in cytokeratin-positive interstitially migrating cytotrophoblast. The co-localization of galectin-1 with extracellular laminin in cultures of cytotrophoblast, choriocarcinoma or decidual stromal cells is consistent with a role in the organization of extracellular matrix and the regulation of cell motility.</description><subject>Antigens, Differentiation - analysis</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Decidua - chemistry</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galectin 1</subject><subject>Galectin 3</subject><subject>Hemagglutinins - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratins - analysis</subject><subject>Laminin - analysis</subject><subject>Membrane Glycoproteins - analysis</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Stromal Cells - chemistry</subject><subject>Tissue Distribution</subject><subject>Trophoblasts - chemistry</subject><subject>Vertebrates: reproduction</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVbPnoQcxIOw7eSj2c1JpGgVCl70HGazCV3ZL5Pdg__eLV169TQD88zMy0PILYMlAy1W-6EOrlsxsRTLVMAZmTOpIOFiDedkDlxlCWOKXZKrGL8BxjZTMzLT65RLKebkaYuVs33ZJIxiU9BE0LKh1lVVpK2n_d5RX4bY0z6UtYu9C7Sr0Lqmx4rmrrgmFx6r6G6muiBfry-fm7dk97F93zzvEivWqk9yLQVK7y1TzoOQUOhUIGfcKuT5OtMZClAuUza3BXKQOpfoQWkFCFw7sSAPx7tdaH-GMYipy3iIiY1rh2hSnXENo5EFWR1BG9oYg_OmG5Nj-DUMzEGZOSozTBhhRmXjxt10eshrV5z4ydE4v5_mGC1WPmBjy3jCOJfA0gP2eMTaofv35x87_oFO</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>VIDOVAC, L</creator><creator>JANKOVIC, M</creator><creator>CUPERLOVIC, M</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Galectin-1 and -3 in cells of the first trimester placental bed</title><author>VIDOVAC, L ; JANKOVIC, M ; CUPERLOVIC, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b943a4ffc16ef0340d973a212c6a2b5898a306e86cbcda2049b4af06960a029e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antigens, Differentiation - analysis</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Decidua - chemistry</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galectin 1</topic><topic>Galectin 3</topic><topic>Hemagglutinins - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratins - analysis</topic><topic>Laminin - analysis</topic><topic>Membrane Glycoproteins - analysis</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Stromal Cells - chemistry</topic><topic>Tissue Distribution</topic><topic>Trophoblasts - chemistry</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VIDOVAC, L</creatorcontrib><creatorcontrib>JANKOVIC, M</creatorcontrib><creatorcontrib>CUPERLOVIC, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VIDOVAC, L</au><au>JANKOVIC, M</au><au>CUPERLOVIC, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galectin-1 and -3 in cells of the first trimester placental bed</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum Reprod</stitle><addtitle>Hum Reprod</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>13</volume><issue>3</issue><spage>730</spage><epage>735</epage><pages>730-735</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>The beta-galactoside-binding proteins galectin-1 and -3 are thought to modulate cell-extracellular matrix interactions in cell adhesion and migration. In this study, their occurrence in human trophoblast has been investigated. In the first trimester placenta galectin-1 is expressed in the cytotrophoblast of the mid and distal cell columns, but absent from the villous and proximal column cytotrophoblast. The villous syncytiotrophoblast was also positive. Galectin-3, on the other hand, was uniformly localized in the villous cytotrophoblast and mid and distal cell columns. Immunolocalization of these proteins in placental bed tissue has shown that galectin-1 and -3 are not present in cytokeratin-positive interstitially migrating cytotrophoblast. The co-localization of galectin-1 with extracellular laminin in cultures of cytotrophoblast, choriocarcinoma or decidual stromal cells is consistent with a role in the organization of extracellular matrix and the regulation of cell motility.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9572443</pmid><doi>10.1093/humrep/13.3.730</doi><tpages>6</tpages></addata></record> |
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| ispartof | Human reproduction (Oxford), 1998-03, Vol.13 (3), p.730-735 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Antigens, Differentiation - analysis Biological and medical sciences Cells, Cultured Decidua - chemistry Female Fundamental and applied biological sciences. Psychology Galectin 1 Galectin 3 Hemagglutinins - analysis Humans Immunohistochemistry Keratins - analysis Laminin - analysis Membrane Glycoproteins - analysis Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy Pregnancy Trimester, First Pregnancy. Parturition. Lactation Stromal Cells - chemistry Tissue Distribution Trophoblasts - chemistry Vertebrates: reproduction |
| title | Galectin-1 and -3 in cells of the first trimester placental bed |
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