Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM

Data from sustained‐release and enteric‐coated oral formulations, and the suppository formulation of diclofenac sodium are fitted simultaneously using NONMEM® and the general linear model, ADVAN 5. Absorption and disposition parameters, serum levels, and absorption profiles were determined. The in v...

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Veröffentlicht in:Biopharmaceutics & drug disposition 1998-04, Vol.19 (3), p.169-174
Hauptverfasser: Idkaidek, Nasir M., Amidon, Gordon L., Smith, David E., Najib, Naji M., Hassan, Mazen M.
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Sprache:eng
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