Cytological changes in endotracheal aspirates associated with chronic lung disease
Endotracheal aspirates taken serially from mechanically ventilated premature infants born at
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| Veröffentlicht in: | Early human development 1998-04, Vol.51 (1), p.13-22 |
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| container_title | Early human development |
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| creator | Todd, David A Earl, Michael Lloyd, Jane Greenberg, Merle John, Elizabeth |
| description | Endotracheal aspirates taken serially from mechanically ventilated premature infants born at |
| doi_str_mv | 10.1016/S0378-3782(97)00069-8 |
| format | Article |
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p<0.05), significantly more required surfactant (14/17 vs. 16/33,
p<0.05) and were ventilated for a significantly longer period (43.3±26.6 vs. 19.3±12.8 days,
p<0.0001). Endotracheal aspirate cytology showed that infants with CLD had significantly more degenerated columnar epithelial cells on day 3 (
p=0.001), and more neutrophils on day 10 (
p=0.007). Though not predictive of CLD, cytological changes consistent with bronchial epithelial and pulmonary damage followed by an inflammatory response were found in the tracheal aspirates of a group of infants clinically diagnosed with CLD.</description><identifier>ISSN: 0378-3782</identifier><identifier>EISSN: 1872-6232</identifier><identifier>DOI: 10.1016/S0378-3782(97)00069-8</identifier><identifier>PMID: 9570027</identifier><identifier>CODEN: EHDEDN</identifier><language>eng</language><publisher>Lausanne: Elsevier Ireland Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Chronic Disease ; Chronic lung disease ; Cytodiagnosis ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Endotracheal aspirate cytology ; Epithelial Cells - pathology ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Intensive care medicine ; Lung Diseases - etiology ; Lung Diseases - pathology ; Male ; Medical sciences ; Oxygen - therapeutic use ; Premature infants ; Respiration, Artificial ; Suction ; Trachea - pathology</subject><ispartof>Early human development, 1998-04, Vol.51 (1), p.13-22</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-ac827406c1a72fca3a5e2f487bd323a04e76216a78abe0a36680dbeaa9487bdf3</citedby><cites>FETCH-LOGICAL-c389t-ac827406c1a72fca3a5e2f487bd323a04e76216a78abe0a36680dbeaa9487bdf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-3782(97)00069-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2227787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9570027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todd, David A</creatorcontrib><creatorcontrib>Earl, Michael</creatorcontrib><creatorcontrib>Lloyd, Jane</creatorcontrib><creatorcontrib>Greenberg, Merle</creatorcontrib><creatorcontrib>John, Elizabeth</creatorcontrib><title>Cytological changes in endotracheal aspirates associated with chronic lung disease</title><title>Early human development</title><addtitle>Early Hum Dev</addtitle><description>Endotracheal aspirates taken serially from mechanically ventilated premature infants born at <28 weeks gestation between March 1992 and August 1993 were studied to determine whether early cytological changes would be a good predictor of lung damage in infants who develop chronic lung disease (CLD). CLD was diagnosed if the infant required supplemental oxygen at 36 weeks corrected gestational age. Fifty-five infants were enrolled in the study, five died and of the 50 infants remaining, 17 (34%) developed CLD. The infants with CLD had a significantly lower gestation (25.5±1.8 (mean±1 SD) versus 26.2±0.9 weeks,
p<0.05), significantly more required surfactant (14/17 vs. 16/33,
p<0.05) and were ventilated for a significantly longer period (43.3±26.6 vs. 19.3±12.8 days,
p<0.0001). Endotracheal aspirate cytology showed that infants with CLD had significantly more degenerated columnar epithelial cells on day 3 (
p=0.001), and more neutrophils on day 10 (
p=0.007). Though not predictive of CLD, cytological changes consistent with bronchial epithelial and pulmonary damage followed by an inflammatory response were found in the tracheal aspirates of a group of infants clinically diagnosed with CLD.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Chronic lung disease</subject><subject>Cytodiagnosis</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Endotracheal aspirate cytology</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intensive care medicine</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxygen - therapeutic use</subject><subject>Premature infants</subject><subject>Respiration, Artificial</subject><subject>Suction</subject><subject>Trachea - pathology</subject><issn>0378-3782</issn><issn>1872-6232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc378hEEvRPSimqZbk16JDL9gIPhxHU7T0y3SNTOnVfbvzbayWy9CQt7nzQkPY6OE3yQ8yW7feSpVHJa4yuU15zzLY3XAhomSIs5EKg7ZcI8csxOirwBNVM4HbJBPJOdCDtnbdN262s2tgToyC2jmSJFtImxK13owCwz3QCvroQ0JEDljw7GMfm27CA3vGmuiumvmUWkJgfCMHVVQE573-yn7fHz4mD7Hs9enl-n9LDapytsYjBJyzDOTgBSVgRQmKKqxkkWZihT4GGUmkgykggI5pFmmeFkgQL5lqvSUXe7eXXn33SG1emnJYF1Dg64jLfMwgHMZwMkONN4Reaz0ytsl-LVOuN641FuXeiNK51JvXWoVeqN-QFcssdy3enkhv-hzoKCv8tAYS3tMCCGl2mB3OwyDjB-LXpOx2BgsrUfT6tLZfz7yB9ixkao</recordid><startdate>19980417</startdate><enddate>19980417</enddate><creator>Todd, David A</creator><creator>Earl, Michael</creator><creator>Lloyd, Jane</creator><creator>Greenberg, Merle</creator><creator>John, Elizabeth</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980417</creationdate><title>Cytological changes in endotracheal aspirates associated with chronic lung disease</title><author>Todd, David A ; Earl, Michael ; Lloyd, Jane ; Greenberg, Merle ; John, Elizabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ac827406c1a72fca3a5e2f487bd323a04e76216a78abe0a36680dbeaa9487bdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Chronic lung disease</topic><topic>Cytodiagnosis</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Endotracheal aspirate cytology</topic><topic>Epithelial Cells - pathology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Intensive care medicine</topic><topic>Lung Diseases - etiology</topic><topic>Lung Diseases - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxygen - therapeutic use</topic><topic>Premature infants</topic><topic>Respiration, Artificial</topic><topic>Suction</topic><topic>Trachea - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todd, David A</creatorcontrib><creatorcontrib>Earl, Michael</creatorcontrib><creatorcontrib>Lloyd, Jane</creatorcontrib><creatorcontrib>Greenberg, Merle</creatorcontrib><creatorcontrib>John, Elizabeth</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Early human development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todd, David A</au><au>Earl, Michael</au><au>Lloyd, Jane</au><au>Greenberg, Merle</au><au>John, Elizabeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytological changes in endotracheal aspirates associated with chronic lung disease</atitle><jtitle>Early human development</jtitle><addtitle>Early Hum Dev</addtitle><date>1998-04-17</date><risdate>1998</risdate><volume>51</volume><issue>1</issue><spage>13</spage><epage>22</epage><pages>13-22</pages><issn>0378-3782</issn><eissn>1872-6232</eissn><coden>EHDEDN</coden><abstract>Endotracheal aspirates taken serially from mechanically ventilated premature infants born at <28 weeks gestation between March 1992 and August 1993 were studied to determine whether early cytological changes would be a good predictor of lung damage in infants who develop chronic lung disease (CLD). CLD was diagnosed if the infant required supplemental oxygen at 36 weeks corrected gestational age. Fifty-five infants were enrolled in the study, five died and of the 50 infants remaining, 17 (34%) developed CLD. The infants with CLD had a significantly lower gestation (25.5±1.8 (mean±1 SD) versus 26.2±0.9 weeks,
p<0.05), significantly more required surfactant (14/17 vs. 16/33,
p<0.05) and were ventilated for a significantly longer period (43.3±26.6 vs. 19.3±12.8 days,
p<0.0001). Endotracheal aspirate cytology showed that infants with CLD had significantly more degenerated columnar epithelial cells on day 3 (
p=0.001), and more neutrophils on day 10 (
p=0.007). Though not predictive of CLD, cytological changes consistent with bronchial epithelial and pulmonary damage followed by an inflammatory response were found in the tracheal aspirates of a group of infants clinically diagnosed with CLD.</abstract><cop>Lausanne</cop><cop>New York,NY</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9570027</pmid><doi>10.1016/S0378-3782(97)00069-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Early human development, 1998-04, Vol.51 (1), p.13-22 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Chronic Disease Chronic lung disease Cytodiagnosis Emergency and intensive care: neonates and children. Prematurity. Sudden death Endotracheal aspirate cytology Epithelial Cells - pathology Female Gestational Age Humans Infant, Newborn Infant, Premature Intensive care medicine Lung Diseases - etiology Lung Diseases - pathology Male Medical sciences Oxygen - therapeutic use Premature infants Respiration, Artificial Suction Trachea - pathology |
| title | Cytological changes in endotracheal aspirates associated with chronic lung disease |
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