Decreased apparent affinity of corticosterone for colonic crypt glucocorticoid receptors is dependent on the cellular milieu and is distinct from corticosterone metabolism

[ 3H]Steroid binding in intact colonic crypt cells and cytosol was compared to determine if 11 β hydroxysteroid dehydrogenase (11 βHSD) activity modulates access of corticosterone (B) to both glucocorticoid receptors (GR) and mineralocorticoid receptors (MR). Cytosol from non-adrenalectomized rat co...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1998-01, Vol.64 (1), p.35-42
1. Verfasser:	Sheppard, K.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	11 β-hydroxysteroid dehydrogenase 11-beta-Hydroxysteroid Dehydrogenases Aldosterone - metabolism Animals Biological and medical sciences Carbenoxolone - pharmacology colon Colon - cytology Colon - metabolism corticosterone Corticosterone - metabolism Cytosol - metabolism Dexamethasone - metabolism Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology glucocorticoid receptor Hydroxysteroid Dehydrogenases - antagonists & inhibitors Hydroxysteroid Dehydrogenases - metabolism In Vitro Techniques Intestine. Mesentery Kinetics Male mineralocorticoid receptor Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - metabolism Vertebrates: digestive system
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