Spironolactone and altizide used in combination with enalapril: Twenty-four-hour ambulatory recording of blood pressure

The addition of enalapril or acebutolol to a regimen of altizide + spironolactone in patients with moderate hypotension was investigated in a multicenter study of S3 patients. The patients underwent semiambulatory 24-hour blood pressure monitoring, especially to observe hypotensive episodes. In the...

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Veröffentlicht in:The American journal of cardiology 1990-06, Vol.65 (23), p.K33-K35
Hauptverfasser: Poncelet, Pascal, Wehrten, Marie, Pelletier, Bruno, Capron, Michel-Hubert
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container_end_page K35
container_issue 23
container_start_page K33
container_title The American journal of cardiology
container_volume 65
creator Poncelet, Pascal
Wehrten, Marie
Pelletier, Bruno
Capron, Michel-Hubert
description The addition of enalapril or acebutolol to a regimen of altizide + spironolactone in patients with moderate hypotension was investigated in a multicenter study of S3 patients. The patients underwent semiambulatory 24-hour blood pressure monitoring, especially to observe hypotensive episodes. In the 25 patients uncontrolled with altizide + spironolactone alone, enalapril and acebutolol were about equally effective in reducing blood pressure. The incidence of hypotension was low and comparable for both treatment groups, provided that the initial dose of angiotensin-converting enzyme inhibitor was low (5 mg).
doi_str_mv 10.1016/0002-9149(90)91275-B
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subjects Acebutolol - administration & dosage
Acebutolol - therapeutic use
Antihypertensive agents
Benzothiadiazines
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Diuretics
Drug Therapy, Combination
Enalapril - administration & dosage
Enalapril - adverse effects
Enalapril - therapeutic use
Female
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Hypotension - diagnosis
Male
Medical sciences
Middle Aged
Monitoring, Physiologic
Multicenter Studies as Topic
Pharmacology. Drug treatments
Randomized Controlled Trials as Topic
Sodium Chloride Symporter Inhibitors - administration & dosage
Sodium Chloride Symporter Inhibitors - therapeutic use
Spironolactone - administration & dosage
Spironolactone - therapeutic use
Sulfonamides - administration & dosage
Sulfonamides - therapeutic use
title Spironolactone and altizide used in combination with enalapril: Twenty-four-hour ambulatory recording of blood pressure
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