Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor

His101 of the GABA(A) receptor alpha1 subunit is an important determinant of benzodiazepine recognition and a major site of photolabeling by [3H]flunitrazepam. To investigate further the chemical specificity of the residue in this position, we substituted it with phenylalanine, tyrosine, lysine, glu...

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Veröffentlicht in:	Journal of neurochemistry 1998-05, Vol.70 (5), p.2188-2194
Hauptverfasser:	Davies, M, Bateson, A N, Dunn, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Animals Azides - metabolism Benzodiazepines - metabolism Carbolines - metabolism Cell Line Flunitrazepam - metabolism GABA Modulators - metabolism Ligands Mutation - physiology Rats Receptors, GABA-A - genetics Receptors, GABA-A - metabolism
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