Further Characterization of Forebrain Serotonin Receptors Mediating Tachycardia in Conscious Rats
It has been shown recently that activation of forebrain serotonin 1A (5-HT 1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT 1A receptor agonist...
Gespeichert in:
| Veröffentlicht in: | Brain research bulletin 1998-04, Vol.45 (6), p.583-588 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 588 |
|---|---|
| container_issue | 6 |
| container_start_page | 583 |
| container_title | Brain research bulletin |
| container_volume | 45 |
| creator | Szabó, András Butz, Brett L Alper, Richard H |
| description | It has been shown recently that activation of forebrain serotonin
1A (5-HT
1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT
1A receptor agonist R(+)-8-hydroxy-2-(di-
n-propylamino) tetralin [R(+)8-OH-DPAT]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-HT
1A receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-HT
2 and 5-HT
3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by R(+)8-OH-DPAT. The data suggest that activation of 5-HT
1A receptors, but not 5-HT
2 or 5-HT
3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. Furthermore, the full response is dependent on afferent serotonergic innervation, suggesting a presynaptic modulatory role for 5-HT in the preoptic area. |
| doi_str_mv | 10.1016/S0361-9230(97)00453-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79823424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S036192309700453X</els_id><sourcerecordid>79823424</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-50b846d93ee72370bcf2ef761a950c5cdd670a540de0d64c8fad17f9b8b168d3</originalsourceid><addsrcrecordid>eNqFkU1vEzEQhi1EVULhJ1TaA0Jw2DL2-mN9QlVEAKlVpTaH3iyvPUuMknWwHaTy63GaKNeePNY88_W-hFxSuKJA5ZcH6CRtNevgk1afAbjo2sdXZEZ71bVMcfWazE7IG_I2598AIHshz8m5FlIKYDNiF7tUVpia-com6wqm8M-WEKcmjs0iJhySDVPzgCmWONXoHh1uS0y5uUUfKjr9apbWrZ6cTfXfVGQep-xC3OXm3pb8jpyNdp3x_fG9IMvFt-X8R3tz9_3n_PqmdZxBaQUMPZded4iKdQoGNzIclaRWC3DCeS8VWMHBI3jJXT9aT9Woh36gsvfdBfl4aLtN8c8OczGbkB2u13bCuopRumcdZ_xFkEoOrO9UBcUBdCnmnHA02xQ2Nj0ZCmZvgXm2wOz1NVqZZwvMY627PA7YDRv0p6qj5jX_4Zi32dn1mOzkQj5h9XhN-X781wOGVbS_AZOpouLkquoJXTE-hhcW-Q8mm6Qr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16402837</pqid></control><display><type>article</type><title>Further Characterization of Forebrain Serotonin Receptors Mediating Tachycardia in Conscious Rats</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Szabó, András ; Butz, Brett L ; Alper, Richard H</creator><creatorcontrib>Szabó, András ; Butz, Brett L ; Alper, Richard H</creatorcontrib><description>It has been shown recently that activation of forebrain serotonin
1A (5-HT
1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT
1A receptor agonist R(+)-8-hydroxy-2-(di-
n-propylamino) tetralin [R(+)8-OH-DPAT]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-HT
1A receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-HT
2 and 5-HT
3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by R(+)8-OH-DPAT. The data suggest that activation of 5-HT
1A receptors, but not 5-HT
2 or 5-HT
3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. Furthermore, the full response is dependent on afferent serotonergic innervation, suggesting a presynaptic modulatory role for 5-HT in the preoptic area.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/S0361-9230(97)00453-X</identifier><identifier>PMID: 9566502</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>5,7-Dihydroxytryptamine - pharmacology ; 5-HT 1A receptors ; 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology ; 8-OH-DPAT ; Animals ; Bicuculline ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Buspirone - pharmacology ; Dopamine - metabolism ; Fundamental and applied biological sciences. Psychology ; Heart rate ; Heart Rate - drug effects ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Norepinephrine - pharmacology ; Preoptic area ; Preoptic Area - drug effects ; Preoptic Area - physiology ; Preoptic Area - physiopathology ; Prosencephalon - drug effects ; Prosencephalon - physiology ; Prosencephalon - physiopathology ; Rats ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT2A ; Receptors, Serotonin - drug effects ; Receptors, Serotonin - physiology ; Receptors, Serotonin, 5-HT1 ; Receptors, Serotonin, 5-HT3 ; Serotonin - metabolism ; Serotonin - pharmacology ; Synapses - physiology ; Tachycardia - physiopathology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research bulletin, 1998-04, Vol.45 (6), p.583-588</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-50b846d93ee72370bcf2ef761a950c5cdd670a540de0d64c8fad17f9b8b168d3</citedby><cites>FETCH-LOGICAL-c420t-50b846d93ee72370bcf2ef761a950c5cdd670a540de0d64c8fad17f9b8b168d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0361-9230(97)00453-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2379147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9566502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabó, András</creatorcontrib><creatorcontrib>Butz, Brett L</creatorcontrib><creatorcontrib>Alper, Richard H</creatorcontrib><title>Further Characterization of Forebrain Serotonin Receptors Mediating Tachycardia in Conscious Rats</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>It has been shown recently that activation of forebrain serotonin
1A (5-HT
1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT
1A receptor agonist R(+)-8-hydroxy-2-(di-
n-propylamino) tetralin [R(+)8-OH-DPAT]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-HT
1A receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-HT
2 and 5-HT
3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by R(+)8-OH-DPAT. The data suggest that activation of 5-HT
1A receptors, but not 5-HT
2 or 5-HT
3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. Furthermore, the full response is dependent on afferent serotonergic innervation, suggesting a presynaptic modulatory role for 5-HT in the preoptic area.</description><subject>5,7-Dihydroxytryptamine - pharmacology</subject><subject>5-HT 1A receptors</subject><subject>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology</subject><subject>8-OH-DPAT</subject><subject>Animals</subject><subject>Bicuculline</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Buspirone - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Norepinephrine - pharmacology</subject><subject>Preoptic area</subject><subject>Preoptic Area - drug effects</subject><subject>Preoptic Area - physiology</subject><subject>Preoptic Area - physiopathology</subject><subject>Prosencephalon - drug effects</subject><subject>Prosencephalon - physiology</subject><subject>Prosencephalon - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Serotonin, 5-HT2A</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Receptors, Serotonin - physiology</subject><subject>Receptors, Serotonin, 5-HT1</subject><subject>Receptors, Serotonin, 5-HT3</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - pharmacology</subject><subject>Synapses - physiology</subject><subject>Tachycardia - physiopathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi1EVULhJ1TaA0Jw2DL2-mN9QlVEAKlVpTaH3iyvPUuMknWwHaTy63GaKNeePNY88_W-hFxSuKJA5ZcH6CRtNevgk1afAbjo2sdXZEZ71bVMcfWazE7IG_I2598AIHshz8m5FlIKYDNiF7tUVpia-com6wqm8M-WEKcmjs0iJhySDVPzgCmWONXoHh1uS0y5uUUfKjr9apbWrZ6cTfXfVGQep-xC3OXm3pb8jpyNdp3x_fG9IMvFt-X8R3tz9_3n_PqmdZxBaQUMPZded4iKdQoGNzIclaRWC3DCeS8VWMHBI3jJXT9aT9Woh36gsvfdBfl4aLtN8c8OczGbkB2u13bCuopRumcdZ_xFkEoOrO9UBcUBdCnmnHA02xQ2Nj0ZCmZvgXm2wOz1NVqZZwvMY627PA7YDRv0p6qj5jX_4Zi32dn1mOzkQj5h9XhN-X781wOGVbS_AZOpouLkquoJXTE-hhcW-Q8mm6Qr</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Szabó, András</creator><creator>Butz, Brett L</creator><creator>Alper, Richard H</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Further Characterization of Forebrain Serotonin Receptors Mediating Tachycardia in Conscious Rats</title><author>Szabó, András ; Butz, Brett L ; Alper, Richard H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-50b846d93ee72370bcf2ef761a950c5cdd670a540de0d64c8fad17f9b8b168d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>5,7-Dihydroxytryptamine - pharmacology</topic><topic>5-HT 1A receptors</topic><topic>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology</topic><topic>8-OH-DPAT</topic><topic>Animals</topic><topic>Bicuculline</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Buspirone - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Norepinephrine - pharmacology</topic><topic>Preoptic area</topic><topic>Preoptic Area - drug effects</topic><topic>Preoptic Area - physiology</topic><topic>Preoptic Area - physiopathology</topic><topic>Prosencephalon - drug effects</topic><topic>Prosencephalon - physiology</topic><topic>Prosencephalon - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Serotonin, 5-HT2A</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Receptors, Serotonin - physiology</topic><topic>Receptors, Serotonin, 5-HT1</topic><topic>Receptors, Serotonin, 5-HT3</topic><topic>Serotonin - metabolism</topic><topic>Serotonin - pharmacology</topic><topic>Synapses - physiology</topic><topic>Tachycardia - physiopathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabó, András</creatorcontrib><creatorcontrib>Butz, Brett L</creatorcontrib><creatorcontrib>Alper, Richard H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabó, András</au><au>Butz, Brett L</au><au>Alper, Richard H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further Characterization of Forebrain Serotonin Receptors Mediating Tachycardia in Conscious Rats</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>45</volume><issue>6</issue><spage>583</spage><epage>588</epage><pages>583-588</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>It has been shown recently that activation of forebrain serotonin
1A (5-HT
1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT
1A receptor agonist R(+)-8-hydroxy-2-(di-
n-propylamino) tetralin [R(+)8-OH-DPAT]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-HT
1A receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-HT
2 and 5-HT
3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by R(+)8-OH-DPAT. The data suggest that activation of 5-HT
1A receptors, but not 5-HT
2 or 5-HT
3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. Furthermore, the full response is dependent on afferent serotonergic innervation, suggesting a presynaptic modulatory role for 5-HT in the preoptic area.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9566502</pmid><doi>10.1016/S0361-9230(97)00453-X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 1998-04, Vol.45 (6), p.583-588 |
| issn | 0361-9230 1873-2747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79823424 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 5,7-Dihydroxytryptamine - pharmacology 5-HT 1A receptors 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology 8-OH-DPAT Animals Bicuculline Biological and medical sciences Blood pressure Blood Pressure - drug effects Buspirone - pharmacology Dopamine - metabolism Fundamental and applied biological sciences. Psychology Heart rate Heart Rate - drug effects Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Norepinephrine - pharmacology Preoptic area Preoptic Area - drug effects Preoptic Area - physiology Preoptic Area - physiopathology Prosencephalon - drug effects Prosencephalon - physiology Prosencephalon - physiopathology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Receptors, Serotonin, 5-HT1 Receptors, Serotonin, 5-HT3 Serotonin - metabolism Serotonin - pharmacology Synapses - physiology Tachycardia - physiopathology Vertebrates: nervous system and sense organs |
| title | Further Characterization of Forebrain Serotonin Receptors Mediating Tachycardia in Conscious Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A28%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Further%20Characterization%20of%20Forebrain%20Serotonin%20Receptors%20Mediating%20Tachycardia%20in%20Conscious%20Rats&rft.jtitle=Brain%20research%20bulletin&rft.au=Szab%C3%B3,%20Andr%C3%A1s&rft.date=1998-04-01&rft.volume=45&rft.issue=6&rft.spage=583&rft.epage=588&rft.pages=583-588&rft.issn=0361-9230&rft.eissn=1873-2747&rft.coden=BRBUDU&rft_id=info:doi/10.1016/S0361-9230(97)00453-X&rft_dat=%3Cproquest_cross%3E79823424%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16402837&rft_id=info:pmid/9566502&rft_els_id=S036192309700453X&rfr_iscdi=true |