Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages

Macrophages in atherosclerotic lesions accumulate large amounts of cholesteryl-fatty acyl esters ("foam cell" formation) through the intracellular esterification of cholesterol by acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). In this study, we sought to determine the subcellular lo...

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Veröffentlicht in:	The Journal of biological chemistry 1998-05, Vol.273 (18), p.11218-11224
Hauptverfasser:	Khelef, N. (Cornell University, Ithaca, NY.), Buton, X, Beatini, N, Wang, H.X, Meiner, V, Chang, T.Y, Farese, R.V. Jr, Maxfield, F.R, Tabas, I
Format:	Artikel
Sprache:	eng
Schlagworte:	ACYLTRANSFERASES Animals Cell Membrane - enzymology CELL MEMBRANES CELL SURFACE Cholesterol - metabolism CYTOPLASM ENDOPLASMIC RETICULUM Esterification Female Fluorescent Antibody Technique IMMUNOCYTOCHEMISTRY IMMUNOLOGY Lipoproteins, VLDL - metabolism MACROPHAGES Macrophages - enzymology Macrophages - metabolism MICE Mice, Inbred C57BL Mice, Inbred ICR NUCLEAR MEMBRANE Sterol O-Acyltransferase - metabolism
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