Structural Examination of the Influence of Phosphorylation on the Binding of Fibrinopeptide A to Bovine Thrombin

Upon addition of thrombin, fibrinopeptides A and B are cleaved off from the N-termini of four chains of fibrinogen (AαBβγ)2, and sites of polymerization are exposed, resulting in formation of a fibrin clot. For the fibrinogen Aα chain, cleavage occurs most prevalently at the Arg16−Gly17 peptide bond...

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