Localized delivery of proteins in the brain : Can transport be customized?

Certain central nervous system (CNS) diseases are characterized by the degeneration of specific cell populations. One strategy for treating neurodegenerative diseases is long-term, controlled delivery of proteins such as epidermal growth factor (EGF) and nerve growth factor (NGF). Since proteins per...

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Veröffentlicht in:	Pharmaceutical research 1998-03, Vol.15 (3), p.377-385
Hauptverfasser:	HALLER, M. F, SALTZMAN, W. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Blood-Brain Barrier - drug effects Brain - blood supply Brain - drug effects Brain - metabolism Diffusion Drug Delivery Systems Drug Implants Epidermal Growth Factor - metabolism Epidermal Growth Factor - therapeutic use Fluorescence General pharmacology Humans Iontophoresis Medical sciences Models, Theoretical Nerve Growth Factors - metabolism Nerve Growth Factors - therapeutic use Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments
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