Coronary vasculopathy in polycythemia vera
Thrombosis is a common complication in polycythemia often causing death. In coronary artery occlusion, thrombosis due to hyperviscosity and thrombocytosis is mostly discussed as the origin of the infarction. We discuss the case of a 30-year-old male patient, with polycythemia, who died of myocardial...
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| Veröffentlicht in: | Pathology oncology research 1998, Vol.4 (1), p.37-39 |
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| creator | Hermanns, B Handt, S Kindler, J Füzesi, L |
| description | Thrombosis is a common complication in polycythemia often causing death. In coronary artery occlusion, thrombosis due to hyperviscosity and thrombocytosis is mostly discussed as the origin of the infarction. We discuss the case of a 30-year-old male patient, with polycythemia, who died of myocardial infarction. On autopsy the vessels showed neither ateriosclerotic changes nor thrombotic occlusions. Instead, a marked intima proliferation was found leading to multiple occlusions whereas media and adventitia were unchanged. This pattern of a coronary vasculopathy has not been described before, and can be interpreted as an alternative mechanism for vascular occlusion in polycythemia. Similar histopathological changes have already been found in skin lesions in erythromelalgia, a common symptom in polycythemia. |
| doi_str_mv | 10.1007/BF02904693 |
| format | Article |
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In coronary artery occlusion, thrombosis due to hyperviscosity and thrombocytosis is mostly discussed as the origin of the infarction. We discuss the case of a 30-year-old male patient, with polycythemia, who died of myocardial infarction. On autopsy the vessels showed neither ateriosclerotic changes nor thrombotic occlusions. Instead, a marked intima proliferation was found leading to multiple occlusions whereas media and adventitia were unchanged. This pattern of a coronary vasculopathy has not been described before, and can be interpreted as an alternative mechanism for vascular occlusion in polycythemia. Similar histopathological changes have already been found in skin lesions in erythromelalgia, a common symptom in polycythemia.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/BF02904693</identifier><identifier>PMID: 9555119</identifier><language>eng</language><publisher>Switzerland: Springer Nature B.V</publisher><subject>Adult ; Autopsy ; Blood cancer ; Cell Division ; Coronary artery ; Coronary Vessels - pathology ; Heart attacks ; Humans ; Male ; Myocardial infarction ; Myocardial Infarction - etiology ; Occlusion ; Oncology ; Pathology ; Polycythemia ; Polycythemia vera ; Polycythemia Vera - complications ; Polycythemia Vera - pathology ; Skin diseases ; Skin lesions ; Thrombocytosis ; Thrombosis ; Tunica Intima - pathology ; Vascular diseases</subject><ispartof>Pathology oncology research, 1998, Vol.4 (1), p.37-39</ispartof><rights>Arányi Lajos Foundation 1998</rights><rights>W B. 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In coronary artery occlusion, thrombosis due to hyperviscosity and thrombocytosis is mostly discussed as the origin of the infarction. We discuss the case of a 30-year-old male patient, with polycythemia, who died of myocardial infarction. On autopsy the vessels showed neither ateriosclerotic changes nor thrombotic occlusions. Instead, a marked intima proliferation was found leading to multiple occlusions whereas media and adventitia were unchanged. This pattern of a coronary vasculopathy has not been described before, and can be interpreted as an alternative mechanism for vascular occlusion in polycythemia. Similar histopathological changes have already been found in skin lesions in erythromelalgia, a common symptom in polycythemia.</description><subject>Adult</subject><subject>Autopsy</subject><subject>Blood cancer</subject><subject>Cell Division</subject><subject>Coronary artery</subject><subject>Coronary Vessels - pathology</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Male</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - etiology</subject><subject>Occlusion</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Polycythemia</subject><subject>Polycythemia vera</subject><subject>Polycythemia Vera - complications</subject><subject>Polycythemia Vera - pathology</subject><subject>Skin diseases</subject><subject>Skin lesions</subject><subject>Thrombocytosis</subject><subject>Thrombosis</subject><subject>Tunica Intima - pathology</subject><subject>Vascular diseases</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90EFLwzAchvEgypzTi3ehIHgYVPNP2iY5anEqDLzouaRJyjrapibtoN_ejA0FD54Swo-X8CB0DfgeMGYPTytMBE4yQU_QHFJKYsIxOw13AiJORJqdowvvtzjgTGQzNBNpmgKIOVrm1tlOuinaSa_GxvZy2ExR3UW9bSY1DRvT1jLaGScv0VklG2-ujucCfa6eP_LXeP3-8pY_rmNFUjrEPJG4MhIMIzwjCVCFBS2rUrNSk6QymimBDbBUMZVpDQTrav-qsRZaYUYX6O6w2zv7NRo_FG3tlWka2Rk7-oIJDoIQEeDtH7i1o-vC3wrCeKjBGOP_KQCgnPIwFtTyoJSz3jtTFb2r29ClAFzsIxe_kQO-OU6OZWv0Dz1Wpd_kNnT9</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Hermanns, B</creator><creator>Handt, S</creator><creator>Kindler, J</creator><creator>Füzesi, L</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Coronary vasculopathy in polycythemia vera</title><author>Hermanns, B ; Handt, S ; Kindler, J ; Füzesi, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-84a0fea1e72862413c093bfbd7bd24fed7c90e175c7c6dd120dffed7d0d9dc073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Autopsy</topic><topic>Blood cancer</topic><topic>Cell Division</topic><topic>Coronary artery</topic><topic>Coronary Vessels - pathology</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Male</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - etiology</topic><topic>Occlusion</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Polycythemia</topic><topic>Polycythemia vera</topic><topic>Polycythemia Vera - complications</topic><topic>Polycythemia Vera - pathology</topic><topic>Skin diseases</topic><topic>Skin lesions</topic><topic>Thrombocytosis</topic><topic>Thrombosis</topic><topic>Tunica Intima - pathology</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermanns, B</creatorcontrib><creatorcontrib>Handt, S</creatorcontrib><creatorcontrib>Kindler, J</creatorcontrib><creatorcontrib>Füzesi, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermanns, B</au><au>Handt, S</au><au>Kindler, J</au><au>Füzesi, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary vasculopathy in polycythemia vera</atitle><jtitle>Pathology oncology research</jtitle><addtitle>Pathol Oncol Res</addtitle><date>1998</date><risdate>1998</risdate><volume>4</volume><issue>1</issue><spage>37</spage><epage>39</epage><pages>37-39</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Thrombosis is a common complication in polycythemia often causing death. In coronary artery occlusion, thrombosis due to hyperviscosity and thrombocytosis is mostly discussed as the origin of the infarction. We discuss the case of a 30-year-old male patient, with polycythemia, who died of myocardial infarction. On autopsy the vessels showed neither ateriosclerotic changes nor thrombotic occlusions. Instead, a marked intima proliferation was found leading to multiple occlusions whereas media and adventitia were unchanged. This pattern of a coronary vasculopathy has not been described before, and can be interpreted as an alternative mechanism for vascular occlusion in polycythemia. Similar histopathological changes have already been found in skin lesions in erythromelalgia, a common symptom in polycythemia.</abstract><cop>Switzerland</cop><pub>Springer Nature B.V</pub><pmid>9555119</pmid><doi>10.1007/BF02904693</doi><tpages>3</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Autopsy Blood cancer Cell Division Coronary artery Coronary Vessels - pathology Heart attacks Humans Male Myocardial infarction Myocardial Infarction - etiology Occlusion Oncology Pathology Polycythemia Polycythemia vera Polycythemia Vera - complications Polycythemia Vera - pathology Skin diseases Skin lesions Thrombocytosis Thrombosis Tunica Intima - pathology Vascular diseases |
| title | Coronary vasculopathy in polycythemia vera |
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