n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants
We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9....
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| Veröffentlicht in: | The American journal of clinical nutrition 1990-06, Vol.51 (6), p.1028-1034 |
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| creator | Kestin, M Clifton, P Belling, GB Nestel, PJ |
| description | We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial. |
| doi_str_mv | 10.1093/ajcn/51.6.1028 |
| format | Article |
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Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/51.6.1028</identifier><identifier>PMID: 1971991</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ACIDE GRAS ; ACIDE LINOLEIQUE ; ACIDE LINOLENIQUE ; ACIDO LINOLEICO ; ACIDO LINOLENICO ; ACIDOS GRASOS ; Adult ; alpha-Linolenic Acid ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; CHOLESTEROL ; Cholesterol, LDL - blood ; COLESTEROL ; DIETA ; Dietary Fats, Unsaturated - pharmacology ; Docosahexaenoic Acids - pharmacology ; Double-Blind Method ; Eicosapentaenoic Acid - pharmacology ; Fatty Acids, Omega-3 - pharmacology ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated - pharmacology ; HOMBRES ; HOMME ; Humans ; Linoleic Acid ; Linoleic Acids - pharmacology ; Linolenic Acids - pharmacology ; LIPIDE ; LIPIDOS ; LIPOPROTEINAS ; LIPOPROTEINE ; Male ; Medical sciences ; Middle Aged ; REGIME ALIMENTAIRE ; SANG ; SANGRE ; TRIGLICERIDOS ; TRIGLYCERIDE ; Triglycerides - blood</subject><ispartof>The American journal of clinical nutrition, 1990-06, Vol.51 (6), p.1028-1034</ispartof><rights>1990 American Society for Nutrition.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-6370c1efa456cc664d7b720cddd2cf22884890b5a47ec9bf88fb014c1727d27a3</citedby><cites>FETCH-LOGICAL-c428t-6370c1efa456cc664d7b720cddd2cf22884890b5a47ec9bf88fb014c1727d27a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19826351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1971991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kestin, M</creatorcontrib><creatorcontrib>Clifton, P</creatorcontrib><creatorcontrib>Belling, GB</creatorcontrib><creatorcontrib>Nestel, PJ</creatorcontrib><title>n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial.</description><subject>ACIDE GRAS</subject><subject>ACIDE LINOLEIQUE</subject><subject>ACIDE LINOLENIQUE</subject><subject>ACIDO LINOLEICO</subject><subject>ACIDO LINOLENICO</subject><subject>ACIDOS GRASOS</subject><subject>Adult</subject><subject>alpha-Linolenic Acid</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>CHOLESTEROL</subject><subject>Cholesterol, LDL - blood</subject><subject>COLESTEROL</subject><subject>DIETA</subject><subject>Dietary Fats, Unsaturated - pharmacology</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Double-Blind Method</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Fatty Acids, Omega-6</subject><subject>Fatty Acids, Unsaturated - pharmacology</subject><subject>HOMBRES</subject><subject>HOMME</subject><subject>Humans</subject><subject>Linoleic Acid</subject><subject>Linoleic Acids - pharmacology</subject><subject>Linolenic Acids - pharmacology</subject><subject>LIPIDE</subject><subject>LIPIDOS</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>REGIME ALIMENTAIRE</subject><subject>SANG</subject><subject>SANGRE</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><subject>Triglycerides - blood</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUuLFDEUhYMoYzu6dSEI2eiuepLUI8lSxic0uNBZh9TNzUyGqkqbVDn0f_HHmqIa1IWrEM537z2cQ8hLzvac6frK3sN01fJ9V75CPSI7rmtV1YLJx2THGBOV5l37lDzL-Z4xLhrVXZALriXXmu_Ir6mqqbfzfKIWgss0ejraFCakMYXbMNEhPmCi-ZTnOASg_RCjo8eEOS8JqZ0cnQs4nABTcJhpv8w02ZCRHt4fKNzFAfOMKQ4U4ni0CR19CPMdXQ-v01PV_WPApzjS42CnOT8nT7wdMr44v5fk5uOH79efq8PXT1-u3x0qaISaq66WDDh627QdQNc1TvZSMHDOCfBCKNUozfrWNhJB914p3zPeAJdCOiFtfUnebnuPKf5Yil0zhgw4FBMYl2ykVlzVLS_gfgMhxZwTenNMocR1MpyZtQ6z1mFabjqz1lEGXp83L_2I7g--5V_0N2fdZrCDT3aCkP_ClOi2w682ztto7G0qzM03zRpeK1lEtYlYMvoZMJkMASdAFxLCbFwM__P3G-88sK0</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Kestin, M</creator><creator>Clifton, P</creator><creator>Belling, GB</creator><creator>Nestel, PJ</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants</title><author>Kestin, M ; Clifton, P ; Belling, GB ; Nestel, PJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-6370c1efa456cc664d7b720cddd2cf22884890b5a47ec9bf88fb014c1727d27a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ACIDE GRAS</topic><topic>ACIDE LINOLEIQUE</topic><topic>ACIDE LINOLENIQUE</topic><topic>ACIDO LINOLEICO</topic><topic>ACIDO LINOLENICO</topic><topic>ACIDOS GRASOS</topic><topic>Adult</topic><topic>alpha-Linolenic Acid</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>CHOLESTEROL</topic><topic>Cholesterol, LDL - blood</topic><topic>COLESTEROL</topic><topic>DIETA</topic><topic>Dietary Fats, Unsaturated - pharmacology</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Double-Blind Method</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Fatty Acids, Omega-6</topic><topic>Fatty Acids, Unsaturated - pharmacology</topic><topic>HOMBRES</topic><topic>HOMME</topic><topic>Humans</topic><topic>Linoleic Acid</topic><topic>Linoleic Acids - pharmacology</topic><topic>Linolenic Acids - pharmacology</topic><topic>LIPIDE</topic><topic>LIPIDOS</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>REGIME ALIMENTAIRE</topic><topic>SANG</topic><topic>SANGRE</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kestin, M</creatorcontrib><creatorcontrib>Clifton, P</creatorcontrib><creatorcontrib>Belling, GB</creatorcontrib><creatorcontrib>Nestel, PJ</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kestin, M</au><au>Clifton, P</au><au>Belling, GB</au><au>Nestel, PJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>51</volume><issue>6</issue><spage>1028</spage><epage>1034</epage><pages>1028-1034</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>1971991</pmid><doi>10.1093/ajcn/51.6.1028</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1990-06, Vol.51 (6), p.1028-1034 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | ACIDE GRAS ACIDE LINOLEIQUE ACIDE LINOLENIQUE ACIDO LINOLEICO ACIDO LINOLENICO ACIDOS GRASOS Adult alpha-Linolenic Acid Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system CHOLESTEROL Cholesterol, LDL - blood COLESTEROL DIETA Dietary Fats, Unsaturated - pharmacology Docosahexaenoic Acids - pharmacology Double-Blind Method Eicosapentaenoic Acid - pharmacology Fatty Acids, Omega-3 - pharmacology Fatty Acids, Omega-6 Fatty Acids, Unsaturated - pharmacology HOMBRES HOMME Humans Linoleic Acid Linoleic Acids - pharmacology Linolenic Acids - pharmacology LIPIDE LIPIDOS LIPOPROTEINAS LIPOPROTEINE Male Medical sciences Middle Aged REGIME ALIMENTAIRE SANG SANGRE TRIGLICERIDOS TRIGLYCERIDE Triglycerides - blood |
| title | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants |
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