Cellular control lies in the balance of forces
Mechanical tension generated within the cytoskeleton of living cells is emerging as a critical regulator of biological function in diverse situations ranging from the control of chromosome movement to the morphogenesis of the vertebrate brain. In this article, we review recent advances that have bee...
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| Veröffentlicht in: | Current opinion in cell biology 1998-04, Vol.10 (2), p.232-239 |
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| container_title | Current opinion in cell biology |
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| creator | Chicurel, Marina E Chen, Christopher S Ingber, Donald E |
| description | Mechanical tension generated within the cytoskeleton of living cells is emerging as a critical regulator of biological function in diverse situations ranging from the control of chromosome movement to the morphogenesis of the vertebrate brain. In this article, we review recent advances that have been made in terms of understanding how cells generate, transmit and sense mechanical tension, as well as how they use these forces to control their shape and behavior. An integrated view of cell regulation that incorporates mechanics and structure as well as chemistry is beginning to emerge. |
| doi_str_mv | 10.1016/S0955-0674(98)80145-2 |
| format | Article |
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| ispartof | Current opinion in cell biology, 1998-04, Vol.10 (2), p.232-239 |
| issn | 0955-0674 1879-0410 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; NASA Technical Reports Server |
| subjects | Animals ECM extracellular matrix FAC focal adhesion complex Humans Life Sciences (General) Models, Biological Signal Transduction Space life sciences Stress, Mechanical |
| title | Cellular control lies in the balance of forces |
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