Plasma Leptin Concentrations in Newborns of Diabetic and Nondiabetic Mothers
ABSTRACT Leptin plays an important role in regulating body composition through modulation of appetite and energy expenditure. We hypothesized that leptin levels in umbilical cord blood correlate with newborn body weight and habitus. We also hypothesized that infants of diabetic mothers would demonst...
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| Veröffentlicht in: | American journal of perinatology 1998-04, Vol.11 (4), p.243-247 |
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| container_title | American journal of perinatology |
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| creator | Gross, Gil A. Solenberger, Thomas Philpott, Timothy Holcomb, William L. Landt, Michael |
| description | ABSTRACT
Leptin plays an important role in regulating body composition through modulation of appetite and energy expenditure. We hypothesized that leptin levels in umbilical cord blood correlate with newborn body weight and habitus. We also hypothesized that infants of diabetic mothers would demonstrate altered leptin metabolism. Venous blood was sampled at birth from the umbilical cords of 105 infants (74 infants of nondiabetic mothers, and 31 infants of diabetic mothers). Thirty-nine mothers had plasma leptin concentrations measured. Analysis was done using Student's T-test, Pearson's correlation, and Spearman's correlation. Univariate/multivariate regression was used for analysis of factors associated with leptin concentration in umbilical cord plasma. Maternal and newborn characteristics were correlated with log leptin levels in umbilical venous plasma. Leptin concentration in umbilical cord plasma correlated best with birth weight for newborns of both nondiabetic and diabetic mothers (P < 0.01 for either). Umbilical cord plasma concentration of leptin was higher in infants of diabetic mothers than in infants of nondiabetic mothers (2.53 ± 1.09 vs. 1.76 ± 0.82; P < 0.001). Multiple regression analysis revealed a significant (P < 0.01) relationship between umbilical cord leptin level and newborn birth weight, as well as maternal DM, but not with gestational age. Similarly, there was no significant correlation with maternal plasma leptin concentration. The strong correlation of leptin concentration in umbilical cord plasma with newborn birth weight, and the lack of significant correlation with maternal leptin plasma levels, suggest that normal fetal leptin metabolism reflects fetal size and/or body habitus independent of maternal leptin metabolism. On the other hand, the higher umbilical plasma levels in infants of diabetic mothers may reflect an influence of altered fetal insulin homeostasis on fetal leptin metabolism, and suggests that maternal diabetes may influence fetal leptin metabolism. |
| doi_str_mv | 10.1055/s-2007-993935 |
| format | Article |
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Leptin plays an important role in regulating body composition through modulation of appetite and energy expenditure. We hypothesized that leptin levels in umbilical cord blood correlate with newborn body weight and habitus. We also hypothesized that infants of diabetic mothers would demonstrate altered leptin metabolism. Venous blood was sampled at birth from the umbilical cords of 105 infants (74 infants of nondiabetic mothers, and 31 infants of diabetic mothers). Thirty-nine mothers had plasma leptin concentrations measured. Analysis was done using Student's T-test, Pearson's correlation, and Spearman's correlation. Univariate/multivariate regression was used for analysis of factors associated with leptin concentration in umbilical cord plasma. Maternal and newborn characteristics were correlated with log leptin levels in umbilical venous plasma. Leptin concentration in umbilical cord plasma correlated best with birth weight for newborns of both nondiabetic and diabetic mothers (P < 0.01 for either). Umbilical cord plasma concentration of leptin was higher in infants of diabetic mothers than in infants of nondiabetic mothers (2.53 ± 1.09 vs. 1.76 ± 0.82; P < 0.001). Multiple regression analysis revealed a significant (P < 0.01) relationship between umbilical cord leptin level and newborn birth weight, as well as maternal DM, but not with gestational age. Similarly, there was no significant correlation with maternal plasma leptin concentration. The strong correlation of leptin concentration in umbilical cord plasma with newborn birth weight, and the lack of significant correlation with maternal leptin plasma levels, suggest that normal fetal leptin metabolism reflects fetal size and/or body habitus independent of maternal leptin metabolism. On the other hand, the higher umbilical plasma levels in infants of diabetic mothers may reflect an influence of altered fetal insulin homeostasis on fetal leptin metabolism, and suggests that maternal diabetes may influence fetal leptin metabolism.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2007-993935</identifier><identifier>PMID: 9565222</identifier><identifier>CODEN: AJPEEK</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Body Weight - physiology ; Cohort Studies ; Diseases of mother, fetus and pregnancy ; Female ; Fetal Blood - chemistry ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Leptin ; Linear Models ; Male ; Medical sciences ; ORIGINAL ARTICLE ; Pregnancy ; Pregnancy in Diabetics - embryology ; Pregnancy. Fetus. Placenta ; Proteins - analysis ; Reference Values</subject><ispartof>American journal of perinatology, 1998-04, Vol.11 (4), p.243-247</ispartof><rights>1998 by Thieme Medical Publishers, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-b427623b7b73fe116177ca918c8a19af9cdbc700141b8304cd5570a06f05fee33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-993935.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-993935$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,778,782,3006,3007,27907,27908,54542,54543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2201527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9565222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gross, Gil A.</creatorcontrib><creatorcontrib>Solenberger, Thomas</creatorcontrib><creatorcontrib>Philpott, Timothy</creatorcontrib><creatorcontrib>Holcomb, William L.</creatorcontrib><creatorcontrib>Landt, Michael</creatorcontrib><title>Plasma Leptin Concentrations in Newborns of Diabetic and Nondiabetic Mothers</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
Leptin plays an important role in regulating body composition through modulation of appetite and energy expenditure. We hypothesized that leptin levels in umbilical cord blood correlate with newborn body weight and habitus. We also hypothesized that infants of diabetic mothers would demonstrate altered leptin metabolism. Venous blood was sampled at birth from the umbilical cords of 105 infants (74 infants of nondiabetic mothers, and 31 infants of diabetic mothers). Thirty-nine mothers had plasma leptin concentrations measured. Analysis was done using Student's T-test, Pearson's correlation, and Spearman's correlation. Univariate/multivariate regression was used for analysis of factors associated with leptin concentration in umbilical cord plasma. Maternal and newborn characteristics were correlated with log leptin levels in umbilical venous plasma. Leptin concentration in umbilical cord plasma correlated best with birth weight for newborns of both nondiabetic and diabetic mothers (P < 0.01 for either). Umbilical cord plasma concentration of leptin was higher in infants of diabetic mothers than in infants of nondiabetic mothers (2.53 ± 1.09 vs. 1.76 ± 0.82; P < 0.001). Multiple regression analysis revealed a significant (P < 0.01) relationship between umbilical cord leptin level and newborn birth weight, as well as maternal DM, but not with gestational age. Similarly, there was no significant correlation with maternal plasma leptin concentration. The strong correlation of leptin concentration in umbilical cord plasma with newborn birth weight, and the lack of significant correlation with maternal leptin plasma levels, suggest that normal fetal leptin metabolism reflects fetal size and/or body habitus independent of maternal leptin metabolism. On the other hand, the higher umbilical plasma levels in infants of diabetic mothers may reflect an influence of altered fetal insulin homeostasis on fetal leptin metabolism, and suggests that maternal diabetes may influence fetal leptin metabolism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Cohort Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Leptin</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>ORIGINAL ARTICLE</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - embryology</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Proteins - analysis</subject><subject>Reference Values</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAQgC0EKqUwMiJlQEwE_Ihje0TlKYXCALPlOLaaKrGLnQjx70mV0I3pXp_uTh8A5wjeIEjpbUwxhCwVgghCD8AcQcFTzjg9BHPICE1RTtAxOIlxAyHCHPIZmAmaU4zxHBTvjYqtSgqz7WqXLL3TxnVBdbV3MRk6K_Nd-jDk3ib3tSpNV-tEuSpZeVf91a--W5sQT8GRVU00Z1NcgM_Hh4_lc1q8Pb0s74pUE5p1aZlhlmNSspIRaxDKEWNaCcQ1V0goK3RVajY8m6GSE5jpilIGFcwtpNYYQhbgaty7Df6rN7GTbR21aRrljO-jZIIjJrIdmI6gDj7GYKzchrpV4UciKHf2ZJQ7e3K0N_AX0-K-bE21pyddw_xymquoVWODcrqOewxjiChmA3Y9Yt26Nq2RG98HNwj55-ovqL2EEw</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Gross, Gil A.</creator><creator>Solenberger, Thomas</creator><creator>Philpott, Timothy</creator><creator>Holcomb, William L.</creator><creator>Landt, Michael</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Plasma Leptin Concentrations in Newborns of Diabetic and Nondiabetic Mothers</title><author>Gross, Gil A. ; Solenberger, Thomas ; Philpott, Timothy ; Holcomb, William L. ; Landt, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-b427623b7b73fe116177ca918c8a19af9cdbc700141b8304cd5570a06f05fee33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Cohort Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Leptin</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>ORIGINAL ARTICLE</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - embryology</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Proteins - analysis</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gross, Gil A.</creatorcontrib><creatorcontrib>Solenberger, Thomas</creatorcontrib><creatorcontrib>Philpott, Timothy</creatorcontrib><creatorcontrib>Holcomb, William L.</creatorcontrib><creatorcontrib>Landt, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gross, Gil A.</au><au>Solenberger, Thomas</au><au>Philpott, Timothy</au><au>Holcomb, William L.</au><au>Landt, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Leptin Concentrations in Newborns of Diabetic and Nondiabetic Mothers</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>11</volume><issue>4</issue><spage>243</spage><epage>247</epage><pages>243-247</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><coden>AJPEEK</coden><abstract>ABSTRACT
Leptin plays an important role in regulating body composition through modulation of appetite and energy expenditure. We hypothesized that leptin levels in umbilical cord blood correlate with newborn body weight and habitus. We also hypothesized that infants of diabetic mothers would demonstrate altered leptin metabolism. Venous blood was sampled at birth from the umbilical cords of 105 infants (74 infants of nondiabetic mothers, and 31 infants of diabetic mothers). Thirty-nine mothers had plasma leptin concentrations measured. Analysis was done using Student's T-test, Pearson's correlation, and Spearman's correlation. Univariate/multivariate regression was used for analysis of factors associated with leptin concentration in umbilical cord plasma. Maternal and newborn characteristics were correlated with log leptin levels in umbilical venous plasma. Leptin concentration in umbilical cord plasma correlated best with birth weight for newborns of both nondiabetic and diabetic mothers (P < 0.01 for either). Umbilical cord plasma concentration of leptin was higher in infants of diabetic mothers than in infants of nondiabetic mothers (2.53 ± 1.09 vs. 1.76 ± 0.82; P < 0.001). Multiple regression analysis revealed a significant (P < 0.01) relationship between umbilical cord leptin level and newborn birth weight, as well as maternal DM, but not with gestational age. Similarly, there was no significant correlation with maternal plasma leptin concentration. The strong correlation of leptin concentration in umbilical cord plasma with newborn birth weight, and the lack of significant correlation with maternal leptin plasma levels, suggest that normal fetal leptin metabolism reflects fetal size and/or body habitus independent of maternal leptin metabolism. On the other hand, the higher umbilical plasma levels in infants of diabetic mothers may reflect an influence of altered fetal insulin homeostasis on fetal leptin metabolism, and suggests that maternal diabetes may influence fetal leptin metabolism.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>9565222</pmid><doi>10.1055/s-2007-993935</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Body Weight - physiology Cohort Studies Diseases of mother, fetus and pregnancy Female Fetal Blood - chemistry Gestational Age Gynecology. Andrology. Obstetrics Humans Infant, Newborn Leptin Linear Models Male Medical sciences ORIGINAL ARTICLE Pregnancy Pregnancy in Diabetics - embryology Pregnancy. Fetus. Placenta Proteins - analysis Reference Values |
| title | Plasma Leptin Concentrations in Newborns of Diabetic and Nondiabetic Mothers |
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