Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange
In 39 patients with acute meningococcal infections, the plasma concentrations of tumor necrosis factor-α (TNF) and its soluble receptors (sRs) TNFsR-p55 and TNFsR-p75 were measured from admission till recovery. At admission, patients with shock had significantly higher TNF, TNFsR-p55, and TNFsR-p75...
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| Veröffentlicht in: | Clinical infectious diseases 1998-04, Vol.26 (4), p.918-923 |
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| creator | van Deuren, Marcel Frieling, Johan T. M. Jongekrijg, Johanna van der Ven Neeleman, Chris Russel, Frans G. M. van Lier, Henk J. J. Bartelink, Anton K. M. van der Meer, Jos W. M. |
| description | In 39 patients with acute meningococcal infections, the plasma concentrations of tumor necrosis factor-α (TNF) and its soluble receptors (sRs) TNFsR-p55 and TNFsR-p75 were measured from admission till recovery. At admission, patients with shock had significantly higher TNF, TNFsR-p55, and TNFsR-p75 values than patients without shock. In addition, during the first 24 hours, patients with shock had higher TNFsR-p75 to TNFsR-p55 ratios, indicating that in shock the increase of TNFsR-p75 exceeds that of TNFsR-p55. TNF measured more than 12 hours after admission failed to differentiate between shock and nonshock because TNF concentrations normalized within 12–24 hours. However, because concentrations of TNFsRs remained elevated for 5–6 days, at that time plasma TNFsRs still differentiated between shock and nonshock. Plasma exchange or whole blood exchange (PEBE), performed in 20 patients with shock, accelerated the decrease of plasma TNFsRs. However, because of a rebound after each PEBE session, the overall half-lives of both TNFsRs were not affected by PEBE. |
| doi_str_mv | 10.1086/513933 |
| format | Article |
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M. ; Jongekrijg, Johanna van der Ven ; Neeleman, Chris ; Russel, Frans G. M. ; van Lier, Henk J. J. ; Bartelink, Anton K. M. ; van der Meer, Jos W. M.</creator><creatorcontrib>van Deuren, Marcel ; Frieling, Johan T. M. ; Jongekrijg, Johanna van der Ven ; Neeleman, Chris ; Russel, Frans G. M. ; van Lier, Henk J. J. ; Bartelink, Anton K. M. ; van der Meer, Jos W. M.</creatorcontrib><description>In 39 patients with acute meningococcal infections, the plasma concentrations of tumor necrosis factor-α (TNF) and its soluble receptors (sRs) TNFsR-p55 and TNFsR-p75 were measured from admission till recovery. At admission, patients with shock had significantly higher TNF, TNFsR-p55, and TNFsR-p75 values than patients without shock. In addition, during the first 24 hours, patients with shock had higher TNFsR-p75 to TNFsR-p55 ratios, indicating that in shock the increase of TNFsR-p75 exceeds that of TNFsR-p55. TNF measured more than 12 hours after admission failed to differentiate between shock and nonshock because TNF concentrations normalized within 12–24 hours. However, because concentrations of TNFsRs remained elevated for 5–6 days, at that time plasma TNFsRs still differentiated between shock and nonshock. Plasma exchange or whole blood exchange (PEBE), performed in 20 patients with shock, accelerated the decrease of plasma TNFsRs. However, because of a rebound after each PEBE session, the overall half-lives of both TNFsRs were not affected by PEBE.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/513933</identifier><identifier>PMID: 9564476</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acute Disease ; Adolescent ; Adult ; Antigens, CD - blood ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Blood ; Blood plasma ; Child ; Child, Preschool ; Clinical Articles ; Cytokines ; Exchange Transfusion, Whole Blood ; Female ; Half lives ; Hospital admissions ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Meningococcal infections ; Meningococcal Infections - blood ; Meningococcal Infections - immunology ; Meningococcal Infections - therapy ; Middle Aged ; Neisseria meningitidis ; Plasma Exchange ; Prospective Studies ; Receptors ; Receptors, Tumor Necrosis Factor - blood ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; Sepsis ; Tumor necrosis factor receptors ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factors</subject><ispartof>Clinical infectious diseases, 1998-04, Vol.26 (4), p.918-923</ispartof><rights>Copyright 1998 The University of Chicago</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-2524e6b018bd4974119c466fff02313b522a77c3219c89a5b10f6b1814f63b853</citedby><cites>FETCH-LOGICAL-c393t-2524e6b018bd4974119c466fff02313b522a77c3219c89a5b10f6b1814f63b853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4481497$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4481497$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2194270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9564476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Deuren, Marcel</creatorcontrib><creatorcontrib>Frieling, Johan T. M.</creatorcontrib><creatorcontrib>Jongekrijg, Johanna van der Ven</creatorcontrib><creatorcontrib>Neeleman, Chris</creatorcontrib><creatorcontrib>Russel, Frans G. M.</creatorcontrib><creatorcontrib>van Lier, Henk J. J.</creatorcontrib><creatorcontrib>Bartelink, Anton K. M.</creatorcontrib><creatorcontrib>van der Meer, Jos W. M.</creatorcontrib><title>Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>In 39 patients with acute meningococcal infections, the plasma concentrations of tumor necrosis factor-α (TNF) and its soluble receptors (sRs) TNFsR-p55 and TNFsR-p75 were measured from admission till recovery. At admission, patients with shock had significantly higher TNF, TNFsR-p55, and TNFsR-p75 values than patients without shock. In addition, during the first 24 hours, patients with shock had higher TNFsR-p75 to TNFsR-p55 ratios, indicating that in shock the increase of TNFsR-p75 exceeds that of TNFsR-p55. TNF measured more than 12 hours after admission failed to differentiate between shock and nonshock because TNF concentrations normalized within 12–24 hours. However, because concentrations of TNFsRs remained elevated for 5–6 days, at that time plasma TNFsRs still differentiated between shock and nonshock. Plasma exchange or whole blood exchange (PEBE), performed in 20 patients with shock, accelerated the decrease of plasma TNFsRs. However, because of a rebound after each PEBE session, the overall half-lives of both TNFsRs were not affected by PEBE.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antigens, CD - blood</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Articles</subject><subject>Cytokines</subject><subject>Exchange Transfusion, Whole Blood</subject><subject>Female</subject><subject>Half lives</subject><subject>Hospital admissions</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningococcal infections</subject><subject>Meningococcal Infections - blood</subject><subject>Meningococcal Infections - immunology</subject><subject>Meningococcal Infections - therapy</subject><subject>Middle Aged</subject><subject>Neisseria meningitidis</subject><subject>Plasma Exchange</subject><subject>Prospective Studies</subject><subject>Receptors</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Receptors, Tumor Necrosis Factor, Type II</subject><subject>Sepsis</subject><subject>Tumor necrosis factor receptors</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factors</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEKqXAE4DkA0JwCHj8P8eq7NKKUgq7SBUXy_HabUoSL3YilefgSXgRnglHG624cfJ4vp9nPPMVxVPAbwAr8ZYDrSi9VxwCp7IUvIL7OcZclUxR9bB4lNItxgAK84PioOKCMSkOi1-XrUmdQZdmGFzsEwoerccuRHThbAypSWhp7BBi-ec3erW-WL5Gpt-gHKBVaMe6deiLs26biYTejbHpr9GxHQeHPro-X4IN1poWnfXe2aEJucP0frhxaOGn1NRw_sPizt6Y_to9Lh540yb3ZD6Piq_LxfrktDz_9P7s5Pi8tHnUoSScMCdqDKresEoygMoyIbz3mFCgNSfESGkpyXlVGV4D9qIGBcwLWitOj4qXu7rbGH6MLg26a5J1bWt6F8akZaVASvg_CIJzUOQfcFpdis7rbWw6E39qwHqySe9syuDzueJYd26zx2Zfsv5i1k3K6_PR9LZJeyyPxIjEGXu2w25TNmAvM5aHrGSWy53cpMHd7WUTv2shqeT69OqbFh8-S7JeXekV_Qshe7C6</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>van Deuren, Marcel</creator><creator>Frieling, Johan T. M.</creator><creator>Jongekrijg, Johanna van der Ven</creator><creator>Neeleman, Chris</creator><creator>Russel, Frans G. M.</creator><creator>van Lier, Henk J. J.</creator><creator>Bartelink, Anton K. M.</creator><creator>van der Meer, Jos W. M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange</title><author>van Deuren, Marcel ; Frieling, Johan T. M. ; Jongekrijg, Johanna van der Ven ; Neeleman, Chris ; Russel, Frans G. M. ; van Lier, Henk J. J. ; Bartelink, Anton K. 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Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood plasma</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Articles</topic><topic>Cytokines</topic><topic>Exchange Transfusion, Whole Blood</topic><topic>Female</topic><topic>Half lives</topic><topic>Hospital admissions</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meningococcal infections</topic><topic>Meningococcal Infections - blood</topic><topic>Meningococcal Infections - immunology</topic><topic>Meningococcal Infections - therapy</topic><topic>Middle Aged</topic><topic>Neisseria meningitidis</topic><topic>Plasma Exchange</topic><topic>Prospective Studies</topic><topic>Receptors</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Receptors, Tumor Necrosis Factor, Type II</topic><topic>Sepsis</topic><topic>Tumor necrosis factor receptors</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Deuren, Marcel</creatorcontrib><creatorcontrib>Frieling, Johan T. M.</creatorcontrib><creatorcontrib>Jongekrijg, Johanna van der Ven</creatorcontrib><creatorcontrib>Neeleman, Chris</creatorcontrib><creatorcontrib>Russel, Frans G. M.</creatorcontrib><creatorcontrib>van Lier, Henk J. J.</creatorcontrib><creatorcontrib>Bartelink, Anton K. M.</creatorcontrib><creatorcontrib>van der Meer, Jos W. M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Deuren, Marcel</au><au>Frieling, Johan T. M.</au><au>Jongekrijg, Johanna van der Ven</au><au>Neeleman, Chris</au><au>Russel, Frans G. M.</au><au>van Lier, Henk J. J.</au><au>Bartelink, Anton K. M.</au><au>van der Meer, Jos W. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>26</volume><issue>4</issue><spage>918</spage><epage>923</epage><pages>918-923</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>In 39 patients with acute meningococcal infections, the plasma concentrations of tumor necrosis factor-α (TNF) and its soluble receptors (sRs) TNFsR-p55 and TNFsR-p75 were measured from admission till recovery. At admission, patients with shock had significantly higher TNF, TNFsR-p55, and TNFsR-p75 values than patients without shock. In addition, during the first 24 hours, patients with shock had higher TNFsR-p75 to TNFsR-p55 ratios, indicating that in shock the increase of TNFsR-p75 exceeds that of TNFsR-p55. TNF measured more than 12 hours after admission failed to differentiate between shock and nonshock because TNF concentrations normalized within 12–24 hours. However, because concentrations of TNFsRs remained elevated for 5–6 days, at that time plasma TNFsRs still differentiated between shock and nonshock. Plasma exchange or whole blood exchange (PEBE), performed in 20 patients with shock, accelerated the decrease of plasma TNFsRs. However, because of a rebound after each PEBE session, the overall half-lives of both TNFsRs were not affected by PEBE.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9564476</pmid><doi>10.1086/513933</doi><tpages>6</tpages></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Adolescent Adult Antigens, CD - blood Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Blood Blood plasma Child Child, Preschool Clinical Articles Cytokines Exchange Transfusion, Whole Blood Female Half lives Hospital admissions Human bacterial diseases Humans Infectious diseases Male Medical sciences Meningococcal infections Meningococcal Infections - blood Meningococcal Infections - immunology Meningococcal Infections - therapy Middle Aged Neisseria meningitidis Plasma Exchange Prospective Studies Receptors Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Sepsis Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factors |
| title | Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange |
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