X-Linked Locus Is Responsible for Non-Insulin-Dependent Diabetes Mellitus in the OLETF Rat
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat has been recently established as the best model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. In this study, we found that the F1 progeny produced from the crosses of OLETF and F344 rats exhibit a reciprocal cross effect on NI...
Gespeichert in:
Veröffentlicht in: | Journal of Veterinary Medical Science 1998, Vol.60(3), pp.373-375 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 375 |
---|---|
container_issue | 3 |
container_start_page | 373 |
container_title | Journal of Veterinary Medical Science |
container_volume | 60 |
creator | MORALEJO, Daniel H. WEI, Suwen WEI, Kaichun YAMADA, Takahisa MATSUMOTO, Kozo |
description | The Otsuka Long-Evans Tokushima Fatty (OLETF) rat has been recently established as the best model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. In this study, we found that the F1 progeny produced from the crosses of OLETF and F344 rats exhibit a reciprocal cross effect on NIDDM-relevant phenotypes, fasting and postprandial glucose levels and body weight, suggesting the existence of X-linked locus affecting susceptibility to NIDDM. We thus examined the linkage between 7 X-linked microsatellite markers and NIDDM-relevant phenotypes, using 160 (OLETF × F344)F 2 progeny. Suggestive evidence for a X-linked locus affecting glucose levels at 120 min after glucose administration was found in a region near X-linked marker, DXMgh4. The identified locus also showed significant effects on fasting glucose levels and body weight. |
doi_str_mv | 10.1292/jvms.60.373 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79815348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3158479431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-a98a2f843cd526da23687a7d40f19b364cf7d7253032508ce0040e6416f737d73</originalsourceid><addsrcrecordid>eNqFkUtrGzEUhUVpSZy0q6wDgkI2ZVy9RhrtGvJoDdMGQgolGyFr7iRyxhpH0hT676Ng40I33eguznePdHQQOqFkTplmn1e_12kuyZwr_gbNKBeqUoLrt2hGNJWVYjU5REcprQhhVEh9gA50LYnSZIbuf1WtD0_Q4XZ0U8KLhG8hbcaQ_HIA3I8R_xhDtQhpGnyoLmEDoYOQ8aW3S8iQ8HcYBp_Lqg84PwK-aa_urvGtze_Ru94OCT7s5jH6eX11d_Gtam--Li7O28oJzXJldWNZ3wjuuprJzjIuG2VVJ0hP9ZJL4XrVlQyc8BKkcUCIICAFlb3iReHH6Gzru4nj8wQpm7VPrrzKBhinZJRuaM1F81-Q6pqVi2QBP_4DrsYphhLClP9rpGpqzgr1aUu5OKYUoTeb6Nc2_jGUmNdizGsxRhJTiin06c5zWq6h27O7Jor-ZauvUrYPsNdtzN4N8NdrexTLveQebTQQ-AuPP530</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1468678532</pqid></control><display><type>article</type><title>X-Linked Locus Is Responsible for Non-Insulin-Dependent Diabetes Mellitus in the OLETF Rat</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>MORALEJO, Daniel H. ; WEI, Suwen ; WEI, Kaichun ; YAMADA, Takahisa ; MATSUMOTO, Kozo</creator><creatorcontrib>MORALEJO, Daniel H. ; WEI, Suwen ; WEI, Kaichun ; YAMADA, Takahisa ; MATSUMOTO, Kozo</creatorcontrib><description>The Otsuka Long-Evans Tokushima Fatty (OLETF) rat has been recently established as the best model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. In this study, we found that the F1 progeny produced from the crosses of OLETF and F344 rats exhibit a reciprocal cross effect on NIDDM-relevant phenotypes, fasting and postprandial glucose levels and body weight, suggesting the existence of X-linked locus affecting susceptibility to NIDDM. We thus examined the linkage between 7 X-linked microsatellite markers and NIDDM-relevant phenotypes, using 160 (OLETF × F344)F 2 progeny. Suggestive evidence for a X-linked locus affecting glucose levels at 120 min after glucose administration was found in a region near X-linked marker, DXMgh4. The identified locus also showed significant effects on fasting glucose levels and body weight.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.60.373</identifier><identifier>PMID: 9560790</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Blood Glucose - metabolism ; Body Weight ; Chromosome Mapping ; Crosses, Genetic ; Diabetes Mellitus - blood ; Diabetes Mellitus - genetics ; Diabetes Mellitus - physiopathology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - physiopathology ; Female ; Genetic Linkage ; Genetic Markers ; Glucose Tolerance Test ; Male ; Microsatellite Repeats ; NIDDM ; Obesity ; OLETF rat ; Phenotype ; Postprandial Period ; Rats ; Rats, Inbred F344 ; Rats, Inbred Strains ; X Chromosome ; X-linkage</subject><ispartof>Journal of Veterinary Medical Science, 1998, Vol.60(3), pp.373-375</ispartof><rights>1998 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-a98a2f843cd526da23687a7d40f19b364cf7d7253032508ce0040e6416f737d73</citedby><cites>FETCH-LOGICAL-c492t-a98a2f843cd526da23687a7d40f19b364cf7d7253032508ce0040e6416f737d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9560790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORALEJO, Daniel H.</creatorcontrib><creatorcontrib>WEI, Suwen</creatorcontrib><creatorcontrib>WEI, Kaichun</creatorcontrib><creatorcontrib>YAMADA, Takahisa</creatorcontrib><creatorcontrib>MATSUMOTO, Kozo</creatorcontrib><title>X-Linked Locus Is Responsible for Non-Insulin-Dependent Diabetes Mellitus in the OLETF Rat</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>The Otsuka Long-Evans Tokushima Fatty (OLETF) rat has been recently established as the best model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. In this study, we found that the F1 progeny produced from the crosses of OLETF and F344 rats exhibit a reciprocal cross effect on NIDDM-relevant phenotypes, fasting and postprandial glucose levels and body weight, suggesting the existence of X-linked locus affecting susceptibility to NIDDM. We thus examined the linkage between 7 X-linked microsatellite markers and NIDDM-relevant phenotypes, using 160 (OLETF × F344)F 2 progeny. Suggestive evidence for a X-linked locus affecting glucose levels at 120 min after glucose administration was found in a region near X-linked marker, DXMgh4. The identified locus also showed significant effects on fasting glucose levels and body weight.</description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>Chromosome Mapping</subject><subject>Crosses, Genetic</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - genetics</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Female</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Glucose Tolerance Test</subject><subject>Male</subject><subject>Microsatellite Repeats</subject><subject>NIDDM</subject><subject>Obesity</subject><subject>OLETF rat</subject><subject>Phenotype</subject><subject>Postprandial Period</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Strains</subject><subject>X Chromosome</subject><subject>X-linkage</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrGzEUhUVpSZy0q6wDgkI2ZVy9RhrtGvJoDdMGQgolGyFr7iRyxhpH0hT676Ng40I33eguznePdHQQOqFkTplmn1e_12kuyZwr_gbNKBeqUoLrt2hGNJWVYjU5REcprQhhVEh9gA50LYnSZIbuf1WtD0_Q4XZ0U8KLhG8hbcaQ_HIA3I8R_xhDtQhpGnyoLmEDoYOQ8aW3S8iQ8HcYBp_Lqg84PwK-aa_urvGtze_Ru94OCT7s5jH6eX11d_Gtam--Li7O28oJzXJldWNZ3wjuuprJzjIuG2VVJ0hP9ZJL4XrVlQyc8BKkcUCIICAFlb3iReHH6Gzru4nj8wQpm7VPrrzKBhinZJRuaM1F81-Q6pqVi2QBP_4DrsYphhLClP9rpGpqzgr1aUu5OKYUoTeb6Nc2_jGUmNdizGsxRhJTiin06c5zWq6h27O7Jor-ZauvUrYPsNdtzN4N8NdrexTLveQebTQQ-AuPP530</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>MORALEJO, Daniel H.</creator><creator>WEI, Suwen</creator><creator>WEI, Kaichun</creator><creator>YAMADA, Takahisa</creator><creator>MATSUMOTO, Kozo</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>X-Linked Locus Is Responsible for Non-Insulin-Dependent Diabetes Mellitus in the OLETF Rat</title><author>MORALEJO, Daniel H. ; WEI, Suwen ; WEI, Kaichun ; YAMADA, Takahisa ; MATSUMOTO, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-a98a2f843cd526da23687a7d40f19b364cf7d7253032508ce0040e6416f737d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>Chromosome Mapping</topic><topic>Crosses, Genetic</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - genetics</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Female</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Glucose Tolerance Test</topic><topic>Male</topic><topic>Microsatellite Repeats</topic><topic>NIDDM</topic><topic>Obesity</topic><topic>OLETF rat</topic><topic>Phenotype</topic><topic>Postprandial Period</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Strains</topic><topic>X Chromosome</topic><topic>X-linkage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORALEJO, Daniel H.</creatorcontrib><creatorcontrib>WEI, Suwen</creatorcontrib><creatorcontrib>WEI, Kaichun</creatorcontrib><creatorcontrib>YAMADA, Takahisa</creatorcontrib><creatorcontrib>MATSUMOTO, Kozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORALEJO, Daniel H.</au><au>WEI, Suwen</au><au>WEI, Kaichun</au><au>YAMADA, Takahisa</au><au>MATSUMOTO, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>X-Linked Locus Is Responsible for Non-Insulin-Dependent Diabetes Mellitus in the OLETF Rat</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>60</volume><issue>3</issue><spage>373</spage><epage>375</epage><pages>373-375</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>The Otsuka Long-Evans Tokushima Fatty (OLETF) rat has been recently established as the best model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. In this study, we found that the F1 progeny produced from the crosses of OLETF and F344 rats exhibit a reciprocal cross effect on NIDDM-relevant phenotypes, fasting and postprandial glucose levels and body weight, suggesting the existence of X-linked locus affecting susceptibility to NIDDM. We thus examined the linkage between 7 X-linked microsatellite markers and NIDDM-relevant phenotypes, using 160 (OLETF × F344)F 2 progeny. Suggestive evidence for a X-linked locus affecting glucose levels at 120 min after glucose administration was found in a region near X-linked marker, DXMgh4. The identified locus also showed significant effects on fasting glucose levels and body weight.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>9560790</pmid><doi>10.1292/jvms.60.373</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0916-7250 |
ispartof | Journal of Veterinary Medical Science, 1998, Vol.60(3), pp.373-375 |
issn | 0916-7250 1347-7439 |
language | eng |
recordid | cdi_proquest_miscellaneous_79815348 |
source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Animals Blood Glucose - metabolism Body Weight Chromosome Mapping Crosses, Genetic Diabetes Mellitus - blood Diabetes Mellitus - genetics Diabetes Mellitus - physiopathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Female Genetic Linkage Genetic Markers Glucose Tolerance Test Male Microsatellite Repeats NIDDM Obesity OLETF rat Phenotype Postprandial Period Rats Rats, Inbred F344 Rats, Inbred Strains X Chromosome X-linkage |
title | X-Linked Locus Is Responsible for Non-Insulin-Dependent Diabetes Mellitus in the OLETF Rat |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T07%3A18%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=X-Linked%20Locus%20Is%20Responsible%20for%20Non-Insulin-Dependent%20Diabetes%20Mellitus%20in%20the%20OLETF%20Rat&rft.jtitle=Journal%20of%20Veterinary%20Medical%20Science&rft.au=MORALEJO,%20Daniel%20H.&rft.date=1998-03-01&rft.volume=60&rft.issue=3&rft.spage=373&rft.epage=375&rft.pages=373-375&rft.issn=0916-7250&rft.eissn=1347-7439&rft_id=info:doi/10.1292/jvms.60.373&rft_dat=%3Cproquest_cross%3E3158479431%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1468678532&rft_id=info:pmid/9560790&rfr_iscdi=true |