Production of Monoclonal Antibodies That Detect Hodgkin's High Molecular Weight Transforming Growth Factor-β

High molecular weight transforming growth factor-β (TGFβ) is a physiologically active TGF secreted by nodular sclerosing Reed-Sternberg cells. Five monoclonal murine antibodies were prepared that distinguished Hodgkin's TGFβ from platelet-derived TGFβ using an enzyme-linked immunosorbent assay,...

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Veröffentlicht in:	Blood 1990-06, Vol.75 (12), p.2434-2437
Hauptverfasser:	Newcom, Samuel R., Muth, Lisa H., Parker, Ernest T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Biological and medical sciences Blotting, Western Enzyme-Linked Immunosorbent Assay Epitopes Hematologic and hematopoietic diseases Hodgkin Disease - immunology Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Weight Transforming Growth Factors - classification Transforming Growth Factors - immunology
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Zusammenfassung:	High molecular weight transforming growth factor-β (TGFβ) is a physiologically active TGF secreted by nodular sclerosing Reed-Sternberg cells. Five monoclonal murine antibodies were prepared that distinguished Hodgkin's TGFβ from platelet-derived TGFβ using an enzyme-linked immunosorbent assay, neutralization of biologic activity, and Western blotting. These monoclonal antibodies directed at unique antigenic determinants (epitopes) of Hodgkin's TGFβ will allow further characterization of the role of Hodgkin's TGFβ in Hodgkin's disease and related entities.
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.V75.12.2434.2434