Which direction do nevus cells move : Abtropfung reexamined
In 1893, Unna published his theory of Abtropfung in which he suggested that melanocytic nevus cells originate in the epidermis and drop off into the dermis. We studied 3,534 nevi from patients of all ages to reassess this almost sacred concept. If Unna was correct, one would expect that in childhood...
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| Veröffentlicht in: | The American journal of dermatopathology 1998-04, Vol.20 (2), p.135-139 |
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| container_title | The American journal of dermatopathology |
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| creator | WORRET, W.-I BURGDORF, W. H. C |
| description | In 1893, Unna published his theory of Abtropfung in which he suggested that melanocytic nevus cells originate in the epidermis and drop off into the dermis. We studied 3,534 nevi from patients of all ages to reassess this almost sacred concept. If Unna was correct, one would expect that in childhood most nevi would be junctional, while in late adult life almost all nevi would be intradermal. In our series, no child under age 10 had a purely junctional nevus, 52% had compound nevi, and 48% had dermal nevi. In patients older than age 60, 12% had junctional nevi, 23% had compound nevi, and 65% had dermal nevi. Our data fail to support the concept of Abtropfung; they fit better with the contradictory theory of upward migration of nevus cells. |
| doi_str_mv | 10.1097/00000372-199804000-00005 |
| format | Article |
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Our data fail to support the concept of Abtropfung; they fit better with the contradictory theory of upward migration of nevus cells.</description><identifier>ISSN: 0193-1091</identifier><identifier>EISSN: 1533-0311</identifier><identifier>DOI: 10.1097/00000372-199804000-00005</identifier><identifier>PMID: 9557780</identifier><identifier>CODEN: AJODDB</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cell Movement ; Child ; Child, Preschool ; Dermatology ; Humans ; Infant ; Infant, Newborn ; Medical sciences ; Middle Aged ; Nevus, Intradermal - pathology ; Nevus, Pigmented - pathology ; Skin Neoplasms - pathology ; Tumors of the skin and soft tissue. 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C</creatorcontrib><title>Which direction do nevus cells move : Abtropfung reexamined</title><title>The American journal of dermatopathology</title><addtitle>Am J Dermatopathol</addtitle><description>In 1893, Unna published his theory of Abtropfung in which he suggested that melanocytic nevus cells originate in the epidermis and drop off into the dermis. We studied 3,534 nevi from patients of all ages to reassess this almost sacred concept. If Unna was correct, one would expect that in childhood most nevi would be junctional, while in late adult life almost all nevi would be intradermal. In our series, no child under age 10 had a purely junctional nevus, 52% had compound nevi, and 48% had dermal nevi. In patients older than age 60, 12% had junctional nevi, 23% had compound nevi, and 65% had dermal nevi. Our data fail to support the concept of Abtropfung; they fit better with the contradictory theory of upward migration of nevus cells.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cell Movement</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nevus, Intradermal - pathology</subject><subject>Nevus, Pigmented - pathology</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. 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Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WORRET, W.-I</creatorcontrib><creatorcontrib>BURGDORF, W. H. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of dermatopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WORRET, W.-I</au><au>BURGDORF, W. H. 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| ispartof | The American journal of dermatopathology, 1998-04, Vol.20 (2), p.135-139 |
| issn | 0193-1091 1533-0311 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cell Movement Child Child, Preschool Dermatology Humans Infant Infant, Newborn Medical sciences Middle Aged Nevus, Intradermal - pathology Nevus, Pigmented - pathology Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Which direction do nevus cells move : Abtropfung reexamined |
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