Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus-mediated gene transfer technique

Supporting cells in the inner ear sensory epithelium are most likely hair cell progenitors. In an effort to establish an in vitro model system of hair cell differentiation, we developed immortalized epithelial cell lines by transferring the tsA58 allele of the SV40 large T antigen oncogene into neon...

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Veröffentlicht in:	Hearing research 1998-03, Vol.117 (1), p.13-23
Hauptverfasser:	Zheng, J.Lisa, Lewis, Annette K, Gao, Wei-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological and medical sciences Calbindin 2 Calmodulin - biosynthesis Cell Differentiation - genetics Cell Division - genetics Cell Line Culture Media, Serum-Free Culture Techniques - methods Differentiation Epidermal Growth Factor - pharmacology Epithelial Cells - cytology Epithelial Cells - drug effects Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Viral - genetics Hair cell Hair Cells, Auditory - cytology Hair Cells, Auditory - drug effects Immortalization Immunohistochemistry Inner ear Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Nerve Tissue Proteins - biosynthesis Proliferation Rats Rats, Wistar Receptors, Growth Factor - metabolism Retroviridae - genetics S100 Calcium Binding Protein G - biosynthesis Saccule and Utricle - cytology Saccule and Utricle - drug effects Space life sciences Supporting cell Transfection Transforming Growth Factor alpha - pharmacology Vertebrates: nervous system and sense organs Vestibular
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