Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA

Peptide nucleic acid (PNA) is a DNA mimic with attractive properties for developing improved gene-targeted antisense agents. To test this potential of PNA in bacteria, PNAs were designed to target the start codon regions of the Escherichia coli β-galactosidase and β-lactamase genes. Dose-dependent a...

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Veröffentlicht in:	Nature biotechnology 1998-04, Vol.16 (4), p.355-358
Hauptverfasser:	Good, Liam, Nielsen, Peter E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Ampicillin - pharmacology Ampicillin Resistance - genetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Galactosidase - genetics beta-Lactamases - genetics Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Codon, Initiator Escherichia coli - enzymology Escherichia coli - genetics Gene Expression Regulation, Bacterial - drug effects Life Sciences Medical sciences Nucleic Acids - pharmacology Peptides - pharmacology Pharmacology. Drug treatments research-article RNA, Messenger - drug effects
Online-Zugang:	Volltext
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