Secretory Phospholipase A2 Cleavage of Intravasated Bone Marrow Primes Human Neutrophils

BACKGROUNDRecent clinical reports suggest that early femoral intramedullary rod (IMR) fixation in patients with multiple injuries increases the risk of adult respiratory distress syndrome (ARDS). We have shown that lipid-mediated neutrophil (PMN) priming and elevated circulating levels of secretory...

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Veröffentlicht in:	The Journal of Trauma: Injury, Infection, and Critical Care Infection, and Critical Care, 1998-04, Vol.44 (4), p.660-664
Hauptverfasser:	Gago, L. April, Moore, Ernest E., Partrick, David A., Sauaia, Angela, Davis, Craig M., Toal, Thomas R., Silliman, Christopher C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Bone Marrow - physiology Femoral Fractures - enzymology Femoral Fractures - immunology Femoral Fractures - surgery Fracture Fixation, Intramedullary - adverse effects Humans Medical sciences Middle Aged Neutrophil Activation - physiology Orthopedic surgery Phospholipases A - physiology Phospholipases A2 Prospective Studies Respiratory Distress Syndrome, Adult - etiology Superoxides - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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