Human Growth Hormone Locally Released in Bone Sites by Calcium‐Phosphate Biomaterial Stimulates Ceramic Bone Substitution Without Systemic Effects: A Rabbit Study

Calcium‐phosphate bone replacement biomaterial has been used as a drug carrier for therapeutic agents. This study investigated the efficacy of local administration of human growth hormone (hGH) by macroporous biphasic calcium phosphate (MBCP) implants in improving the bone substitution qualities of...

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Veröffentlicht in:	Journal of bone and mineral research 1998-04, Vol.13 (4), p.739-748
Hauptverfasser:	Guicheux, Jérôme, Gauthier, Olivier, Aguado, Eric, Pilet, Paul, Couillaud, Séverine, Jegou, Dominique, Daculsi, Guy, Heymann, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - administration & dosage Biological and medical sciences Bone Resorption Calcium Phosphates - administration & dosage Ceramics Drug Delivery Systems Drug Implants Female Femur - drug effects Femur - ultrastructure Hip Prosthesis Human Growth Hormone - administration & dosage Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Porosity Prostheses and Implants Rabbits Radioimmunoassay Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments
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