5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion
TO investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double...
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| Veröffentlicht in: | Neuroreport 1998-03, Vol.9 (4), p.641-645 |
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| creator | Bonaventure, Pascal Voorn, Pieter Luyten, Walter H. M. L Leysen, Josée E |
| description | TO investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties. |
| doi_str_mv | 10.1097/00001756-199803090-00015 |
| format | Article |
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M. L ; Leysen, Josée E</creator><creatorcontrib>Bonaventure, Pascal ; Voorn, Pieter ; Luyten, Walter H. M. L ; Leysen, Josée E</creatorcontrib><description>TO investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199803090-00015</identifier><identifier>PMID: 9559931</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biological and medical sciences ; Calcitonin Gene-Related Peptide - biosynthesis ; Guinea Pigs ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; In Situ Hybridization ; Inflammation ; Male ; Medical sciences ; Nerve Fibers - metabolism ; Nervous system (semeiology, syndromes) ; Neurology ; Receptor, Serotonin, 5-HT1B ; Receptor, Serotonin, 5-HT1D ; Receptors, Serotonin - biosynthesis ; RNA, Messenger - metabolism ; Substance P - biosynthesis ; Trigeminal Ganglion - metabolism</subject><ispartof>Neuroreport, 1998-03, Vol.9 (4), p.641-645</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2315-af40246b3ba25a9eb2241b4ed05b3a5f72aff411968a493db792e70a826dce333</citedby><cites>FETCH-LOGICAL-c2315-af40246b3ba25a9eb2241b4ed05b3a5f72aff411968a493db792e70a826dce333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2168214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9559931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonaventure, Pascal</creatorcontrib><creatorcontrib>Voorn, Pieter</creatorcontrib><creatorcontrib>Luyten, Walter H. M. L</creatorcontrib><creatorcontrib>Leysen, Josée E</creatorcontrib><title>5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>TO investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide - biosynthesis</subject><subject>Guinea Pigs</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>In Situ Hybridization</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Fibers - metabolism</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Receptor, Serotonin, 5-HT1B</subject><subject>Receptor, Serotonin, 5-HT1D</subject><subject>Receptors, Serotonin - biosynthesis</subject><subject>RNA, Messenger - metabolism</subject><subject>Substance P - biosynthesis</subject><subject>Trigeminal Ganglion - metabolism</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi1EVbaFn4DkA-KW4s8kPpbyUaSqSKhI3KxJMskanA9sRyv66-tll73hy1ie5x1LzxBCObvizFTvWD680mXBjamZZIYV-xf9jGy4qmShdf3jOdkwo02hTKlfkIsYf2bEMF6fk3OjtTGSb0jQtw_8PYWpo_vbBxqwxSXNgY7f7q9p5_oeA07JgaftXPi5Be8eIbl5ojuXtnTJtOvwgLuJpi3SYXUTAl3cQFNwA45uyvEBpsHn3Ety1oOP-OpYL8n3Tx8fbm6Lu6-fv9xc3xWtkFwX0CsmVNnIBoQGg40QijcKO6YbCbqvBPS94tyUNSgju6YyAisGtSi7FqWUl-TtYe4S5t8rxmRHF1v0Hiac12grU3PGRZnB-gC2YY4xYG-X4EYIfyxndq_b_tNtT7rtX905-vr4x9qM2J2CR7-5_-bYh5jN9QGm1sUTJnhZC64ypg7YbvYJQ_zl1x0Gu0XwaWv_t2z5BPhYloM</recordid><startdate>19980309</startdate><enddate>19980309</enddate><creator>Bonaventure, Pascal</creator><creator>Voorn, Pieter</creator><creator>Luyten, Walter H. M. L</creator><creator>Leysen, Josée E</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980309</creationdate><title>5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion</title><author>Bonaventure, Pascal ; Voorn, Pieter ; Luyten, Walter H. M. L ; Leysen, Josée E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2315-af40246b3ba25a9eb2241b4ed05b3a5f72aff411968a493db792e70a826dce333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide - biosynthesis</topic><topic>Guinea Pigs</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>In Situ Hybridization</topic><topic>Inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Fibers - metabolism</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Receptor, Serotonin, 5-HT1B</topic><topic>Receptor, Serotonin, 5-HT1D</topic><topic>Receptors, Serotonin - biosynthesis</topic><topic>RNA, Messenger - metabolism</topic><topic>Substance P - biosynthesis</topic><topic>Trigeminal Ganglion - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonaventure, Pascal</creatorcontrib><creatorcontrib>Voorn, Pieter</creatorcontrib><creatorcontrib>Luyten, Walter H. M. 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L</au><au>Leysen, Josée E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-03-09</date><risdate>1998</risdate><volume>9</volume><issue>4</issue><spage>641</spage><epage>645</epage><pages>641-645</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>TO investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9559931</pmid><doi>10.1097/00001756-199803090-00015</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroreport, 1998-03, Vol.9 (4), p.641-645 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Calcitonin Gene-Related Peptide - biosynthesis Guinea Pigs Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy In Situ Hybridization Inflammation Male Medical sciences Nerve Fibers - metabolism Nervous system (semeiology, syndromes) Neurology Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin - biosynthesis RNA, Messenger - metabolism Substance P - biosynthesis Trigeminal Ganglion - metabolism |
| title | 5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion |
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