Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood

Cytotoxic T lymphocytes (CTLs) play an important role in controlling viral infections and certain tumours, but characterising specific CTL responses has always been technically limited. Fluorogenic ‘tetramers’ of major histocompatibility complex (MHC) class I complexes have been exploited recently t...

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Veröffentlicht in:	Current biology 1998-03, Vol.8 (7), p.413-416
Hauptverfasser:	Dunbar, P.R., Ogg, G.S., Chen, J., Rust, N., van der Bruggen, P., Cerundolo, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Cell Separation Clone Cells Flow Cytometry HLA-A2 Antigen - chemistry HLA-A2 Antigen - metabolism Humans Immunophenotyping Lymphocytes, Tumor-Infiltrating - cytology Lymphocytes, Tumor-Infiltrating - immunology Melanoma - immunology Melanoma - pathology Protein Conformation T-Lymphocytes, Cytotoxic - immunology
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