Experimental Autoimmune Prostatitis: In Vivo Induction of the Autoimmune Response to Lymphocytic Soluble Factors. Alterations at the Endocrine Metabolism Level

PROBLEM: In rats, immunization with male accessory gland (MAG) extract promotes experimental autoimmune vesicle prostatitis. A specific mononuclear cell‐mediated immune response and prostate androgen metabolism impairment in MAG‐immunized rats were observed. The possibility that lymphocytic soluble...

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Veröffentlicht in:American journal of reproductive immunology (1989) 1998-04, Vol.39 (4), p.226-234
Hauptverfasser: Diserio, Gustavo P., Nowotny, Edgar
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container_title American journal of reproductive immunology (1989)
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creator Diserio, Gustavo P.
Nowotny, Edgar
description PROBLEM: In rats, immunization with male accessory gland (MAG) extract promotes experimental autoimmune vesicle prostatitis. A specific mononuclear cell‐mediated immune response and prostate androgen metabolism impairment in MAG‐immunized rats were observed. The possibility that lymphocytic soluble factors (SoFs) can regulate the local steroid metabolism in these rats directly was studied. We investigated whether the SoFs released by MAG‐sensitized lymphocytes are capable of modifying the prostatic androgen metabolism and whether they induce histologic lesions “in vivo” when they are inoculated, carried by liposomes, into untreated rats. METHOD OF STUDY: “In vitro” enzymatic [3H]‐5α‐dihydrotestosterone bioconversion and histologic studies were performed with prostates from SoF‐treated rats (LK rats). The obtained 3α/β‐hydroxysteroid‐oxidoreductase activities showed that LK rat values were significantly lower than in controls: 79.0 ± 2.5 vs 158.7 ± 10.2 pmol/min/mg protein, respectively (P < 0.01). RESULTS: In the histologic studies, LK rat prostates showed focalized mononuclear infiltrates of various degrees, whereas control rats showed non‐atypic modification of the gland. CONCLUSION: These results indicate that SoFs (probably total lymphokines) contribute significantly to the pathogenesis of experimental autoimmune prostatitis, involving a biochemical relationship between immune reaction and the androgenic enzymatic inhibition in the prostate.
doi_str_mv 10.1111/j.1600-0897.1998.tb00358.x
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Alterations at the Endocrine Metabolism Level</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Diserio, Gustavo P. ; Nowotny, Edgar</creator><creatorcontrib>Diserio, Gustavo P. ; Nowotny, Edgar</creatorcontrib><description>PROBLEM: In rats, immunization with male accessory gland (MAG) extract promotes experimental autoimmune vesicle prostatitis. A specific mononuclear cell‐mediated immune response and prostate androgen metabolism impairment in MAG‐immunized rats were observed. The possibility that lymphocytic soluble factors (SoFs) can regulate the local steroid metabolism in these rats directly was studied. We investigated whether the SoFs released by MAG‐sensitized lymphocytes are capable of modifying the prostatic androgen metabolism and whether they induce histologic lesions “in vivo” when they are inoculated, carried by liposomes, into untreated rats. METHOD OF STUDY: “In vitro” enzymatic [3H]‐5α‐dihydrotestosterone bioconversion and histologic studies were performed with prostates from SoF‐treated rats (LK rats). The obtained 3α/β‐hydroxysteroid‐oxidoreductase activities showed that LK rat values were significantly lower than in controls: 79.0 ± 2.5 vs 158.7 ± 10.2 pmol/min/mg protein, respectively (P &lt; 0.01). RESULTS: In the histologic studies, LK rat prostates showed focalized mononuclear infiltrates of various degrees, whereas control rats showed non‐atypic modification of the gland. CONCLUSION: These results indicate that SoFs (probably total lymphokines) contribute significantly to the pathogenesis of experimental autoimmune prostatitis, involving a biochemical relationship between immune reaction and the androgenic enzymatic inhibition in the prostate.</description><identifier>ISSN: 1046-7408</identifier><identifier>ISSN: 8755-8920</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/j.1600-0897.1998.tb00358.x</identifier><identifier>PMID: 9553646</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Androgen metabolism ; Animals ; Autoimmune Diseases - immunology ; autoimmune prostatitis ; Biological and medical sciences ; cytokines ; Dihydrotestosterone - metabolism ; Lymphokines - immunology ; Male ; Medical sciences ; Mitogens - immunology ; Nephrology. Urinary tract diseases ; prostate ; Prostate - pathology ; Prostatitis - immunology ; Rats ; Rats, Wistar ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. 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Alterations at the Endocrine Metabolism Level</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>PROBLEM: In rats, immunization with male accessory gland (MAG) extract promotes experimental autoimmune vesicle prostatitis. A specific mononuclear cell‐mediated immune response and prostate androgen metabolism impairment in MAG‐immunized rats were observed. The possibility that lymphocytic soluble factors (SoFs) can regulate the local steroid metabolism in these rats directly was studied. We investigated whether the SoFs released by MAG‐sensitized lymphocytes are capable of modifying the prostatic androgen metabolism and whether they induce histologic lesions “in vivo” when they are inoculated, carried by liposomes, into untreated rats. METHOD OF STUDY: “In vitro” enzymatic [3H]‐5α‐dihydrotestosterone bioconversion and histologic studies were performed with prostates from SoF‐treated rats (LK rats). The obtained 3α/β‐hydroxysteroid‐oxidoreductase activities showed that LK rat values were significantly lower than in controls: 79.0 ± 2.5 vs 158.7 ± 10.2 pmol/min/mg protein, respectively (P &lt; 0.01). RESULTS: In the histologic studies, LK rat prostates showed focalized mononuclear infiltrates of various degrees, whereas control rats showed non‐atypic modification of the gland. CONCLUSION: These results indicate that SoFs (probably total lymphokines) contribute significantly to the pathogenesis of experimental autoimmune prostatitis, involving a biochemical relationship between immune reaction and the androgenic enzymatic inhibition in the prostate.</description><subject>Androgen metabolism</subject><subject>Animals</subject><subject>Autoimmune Diseases - immunology</subject><subject>autoimmune prostatitis</subject><subject>Biological and medical sciences</subject><subject>cytokines</subject><subject>Dihydrotestosterone - metabolism</subject><subject>Lymphokines - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitogens - immunology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>prostate</subject><subject>Prostate - pathology</subject><subject>Prostatitis - immunology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>1046-7408</issn><issn>8755-8920</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkdGO1CAUhhujWdfVRzAhxnjXCoVS2AuT2c3MOqauRldN9oZQhmYZaamFrjNP46tKnWbinZGbc-D85wPOnyQvEMxQXK-3GaIQppDxMkOcsyzUEOKCZbsHyemx9DDmkNC0JJA9Tp54v4UwnuPyJDnhRYEpoafJr-Wu14NpdRekBYsxONO2Y6fBx8H5IIMJxp-DdQe-mnsX42ZUwbgOuAaEO_13wyfte9d5DYID1b7t75zaB6PAZ2fH2mqwkiq4wWdgYYMe5ETxQIY_mGW3cWowkfJeB1k7a3wLKn2v7dPkUSOt18_meJZ8WS1vLt-m1Yer9eWiShWhJUv5pqYYcgilahjWWJKa5FJCnkPESYNzXaJNnAxlmDSFakgJ466uGYRFXXCKz5JXB24_uB-j9kG0xittrey0G70oOYMsz_E_hYgSUtByEp4fhCpO0g-6EX2csxz2AkEx2Si2YvJKTF6JyUYx2yh2sfn5fMtYt3pzbJ19i_WXc116JW0zyE4Zf5TliFHKUZS9Och-Gqv3__EAsXi3jkkEpAeA8UHvjgA5fBfxj2Uhvl1fCVytbq9v0IW4xb8B94_LLw</recordid><startdate>199804</startdate><enddate>199804</enddate><creator>Diserio, Gustavo P.</creator><creator>Nowotny, Edgar</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199804</creationdate><title>Experimental Autoimmune Prostatitis: In Vivo Induction of the Autoimmune Response to Lymphocytic Soluble Factors. Alterations at the Endocrine Metabolism Level</title><author>Diserio, Gustavo P. ; Nowotny, Edgar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4678-9db630900acf83e3a4b42aa0920194f32e71d1606834f5cf470160bb8005b5963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Androgen metabolism</topic><topic>Animals</topic><topic>Autoimmune Diseases - immunology</topic><topic>autoimmune prostatitis</topic><topic>Biological and medical sciences</topic><topic>cytokines</topic><topic>Dihydrotestosterone - metabolism</topic><topic>Lymphokines - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitogens - immunology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>prostate</topic><topic>Prostate - pathology</topic><topic>Prostatitis - immunology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diserio, Gustavo P.</creatorcontrib><creatorcontrib>Nowotny, Edgar</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diserio, Gustavo P.</au><au>Nowotny, Edgar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Autoimmune Prostatitis: In Vivo Induction of the Autoimmune Response to Lymphocytic Soluble Factors. Alterations at the Endocrine Metabolism Level</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>1998-04</date><risdate>1998</risdate><volume>39</volume><issue>4</issue><spage>226</spage><epage>234</epage><pages>226-234</pages><issn>1046-7408</issn><issn>8755-8920</issn><eissn>1600-0897</eissn><abstract>PROBLEM: In rats, immunization with male accessory gland (MAG) extract promotes experimental autoimmune vesicle prostatitis. A specific mononuclear cell‐mediated immune response and prostate androgen metabolism impairment in MAG‐immunized rats were observed. The possibility that lymphocytic soluble factors (SoFs) can regulate the local steroid metabolism in these rats directly was studied. We investigated whether the SoFs released by MAG‐sensitized lymphocytes are capable of modifying the prostatic androgen metabolism and whether they induce histologic lesions “in vivo” when they are inoculated, carried by liposomes, into untreated rats. METHOD OF STUDY: “In vitro” enzymatic [3H]‐5α‐dihydrotestosterone bioconversion and histologic studies were performed with prostates from SoF‐treated rats (LK rats). The obtained 3α/β‐hydroxysteroid‐oxidoreductase activities showed that LK rat values were significantly lower than in controls: 79.0 ± 2.5 vs 158.7 ± 10.2 pmol/min/mg protein, respectively (P &lt; 0.01). RESULTS: In the histologic studies, LK rat prostates showed focalized mononuclear infiltrates of various degrees, whereas control rats showed non‐atypic modification of the gland. CONCLUSION: These results indicate that SoFs (probably total lymphokines) contribute significantly to the pathogenesis of experimental autoimmune prostatitis, involving a biochemical relationship between immune reaction and the androgenic enzymatic inhibition in the prostate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9553646</pmid><doi>10.1111/j.1600-0897.1998.tb00358.x</doi><tpages>9</tpages></addata></record>
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identifier ISSN: 1046-7408
ispartof American journal of reproductive immunology (1989), 1998-04, Vol.39 (4), p.226-234
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8755-8920
1600-0897
language eng
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source MEDLINE; Access via Wiley Online Library
subjects Androgen metabolism
Animals
Autoimmune Diseases - immunology
autoimmune prostatitis
Biological and medical sciences
cytokines
Dihydrotestosterone - metabolism
Lymphokines - immunology
Male
Medical sciences
Mitogens - immunology
Nephrology. Urinary tract diseases
prostate
Prostate - pathology
Prostatitis - immunology
Rats
Rats, Wistar
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
title Experimental Autoimmune Prostatitis: In Vivo Induction of the Autoimmune Response to Lymphocytic Soluble Factors. Alterations at the Endocrine Metabolism Level
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