Comparative Effects of Glibenclamide, Tedisamil, Dofetilide, E-4031, and BRL-32872 on Protein Kinase A-Activated Chloride Current in Guinea Pig Ventricular Myocytes

The modulation of the protein kinase A-activated chloride current (PKA-ICl) may lead to modification of the cardiac action potential shape. The purpose of this study was to evaluate the effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on the PKA-ICl. Experiments were conducted...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1998-04, Vol.31 (4), p.551-557
Hauptverfasser:	Faivre, Jean-François, Rouanet, Sabine, Bril, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid - pharmacology Acetylcholine - pharmacology Animals Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Benzamides - pharmacology Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cardiotonic Agents - pharmacology Cardiovascular system Chlorides - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Cyclopropanes - pharmacology Glyburide - pharmacology Guinea Pigs Heart Ventricles - drug effects Hypoglycemic Agents - pharmacology Ion Transport - drug effects Isoproterenol - pharmacology Male Medical sciences Myocardium - metabolism Patch-Clamp Techniques Pharmacology. Drug treatments Phenethylamines - pharmacology Piperidines - pharmacology Potassium Channels - drug effects Propranolol - pharmacology Pyridines - pharmacology Sulfonamides - pharmacology
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