Importance of MEK in Neutrophil Microbicidal Responsiveness

Exposure of neutrophils to inflammatory stimuli such as the chemoattractant FMLP leads to activation of responses including cell motility, the oxidative burst, and secretion of proteolytic enzymes. A signaling cascade involving sequential activation of Raf-1, mitogen-activated protein kinase (MEK),...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-01, Vol.160 (1), p.434-443
Hauptverfasser:	Downey, Gregory P, Butler, Jeffrey R, Tapper, Hans, Fialkow, Lea, Saltiel, Alan R, Rubin, Barry B, Grinstein, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Apoptosis - drug effects Blood Bactericidal Activity Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Degranulation - drug effects Chemotaxis, Leukocyte - drug effects Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Humans MAP Kinase Kinase 1 MAP Kinase Kinase 2 Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Neutrophils - enzymology Phagocytosis - drug effects Phospholipases A - metabolism Phospholipases A2 Phosphotyrosine - metabolism Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Respiratory Burst - drug effects
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