MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes
We have developed and shown to be efficacious an immunotherapeutic strategy to enhance the generation of tumor-specific CD4+ T helper lymphocytes. The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hypoth...
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| Veröffentlicht in: | The Journal of immunology (1950) 1998-01, Vol.160 (2), p.661-666 |
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| container_title | The Journal of immunology (1950) |
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| creator | Armstrong, T D Clements, V K Ostrand-Rosenberg, S |
| description | We have developed and shown to be efficacious an immunotherapeutic strategy to enhance the generation of tumor-specific CD4+ T helper lymphocytes. The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hypothesis that tumor cells directly present tumor Ags to CD4+ T cells. Since the conventional pathway for CD4+ T cell activation is indirect via professional APC, induction of immunity following immunization with class II-transfected tumor cells was examined in bone marrow chimeric mice. Both tumor and host-derived cells are APC for tumor Ags, suggesting that the efficacy of tumor cell vaccines can be significantly improved by genetic modifications that enhance tumor cell Ag presentation. |
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The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hypothesis that tumor cells directly present tumor Ags to CD4+ T cells. Since the conventional pathway for CD4+ T cell activation is indirect via professional APC, induction of immunity following immunization with class II-transfected tumor cells was examined in bone marrow chimeric mice. Both tumor and host-derived cells are APC for tumor Ags, suggesting that the efficacy of tumor cell vaccines can be significantly improved by genetic modifications that enhance tumor cell Ag presentation.</description><identifier>ISSN: 0022-1767</identifier><identifier>PMID: 9551900</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antigen Presentation - genetics ; Antigen-Presenting Cells - immunology ; Antigen-Presenting Cells - metabolism ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - metabolism ; Cell Membrane - immunology ; Cell Membrane - metabolism ; Female ; Gene Expression Regulation, Neoplastic - immunology ; Genotype ; Histocompatibility Antigens Class II - biosynthesis ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Antigens Class II - metabolism ; Intracellular Fluid - immunology ; Intracellular Fluid - metabolism ; Lymphocyte Activation - genetics ; Mice ; Mice, Inbred A ; Mice, Inbred C57BL ; Muramidase - biosynthesis ; Muramidase - genetics ; Muramidase - immunology ; Peptide Fragments - immunology ; Peptide Fragments - metabolism ; Radiation Chimera - genetics ; Radiation Chimera - immunology ; Sarcoma, Experimental - genetics ; Sarcoma, Experimental - immunology ; Species Specificity ; T-Lymphocyte Subsets - immunology ; Transfection - immunology ; Tumor Cells, Cultured</subject><ispartof>The Journal of immunology (1950), 1998-01, Vol.160 (2), p.661-666</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9551900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armstrong, T D</creatorcontrib><creatorcontrib>Clements, V K</creatorcontrib><creatorcontrib>Ostrand-Rosenberg, S</creatorcontrib><title>MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>We have developed and shown to be efficacious an immunotherapeutic strategy to enhance the generation of tumor-specific CD4+ T helper lymphocytes. The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hypothesis that tumor cells directly present tumor Ags to CD4+ T cells. Since the conventional pathway for CD4+ T cell activation is indirect via professional APC, induction of immunity following immunization with class II-transfected tumor cells was examined in bone marrow chimeric mice. Both tumor and host-derived cells are APC for tumor Ags, suggesting that the efficacy of tumor cell vaccines can be significantly improved by genetic modifications that enhance tumor cell Ag presentation.</description><subject>Animals</subject><subject>Antigen Presentation - genetics</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Antigen-Presenting Cells - metabolism</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>Cell Membrane - immunology</subject><subject>Cell Membrane - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic - immunology</subject><subject>Genotype</subject><subject>Histocompatibility Antigens Class II - biosynthesis</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Antigens Class II - metabolism</subject><subject>Intracellular Fluid - immunology</subject><subject>Intracellular Fluid - metabolism</subject><subject>Lymphocyte Activation - genetics</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Mice, Inbred C57BL</subject><subject>Muramidase - biosynthesis</subject><subject>Muramidase - genetics</subject><subject>Muramidase - immunology</subject><subject>Peptide Fragments - immunology</subject><subject>Peptide Fragments - metabolism</subject><subject>Radiation Chimera - genetics</subject><subject>Radiation Chimera - immunology</subject><subject>Sarcoma, Experimental - genetics</subject><subject>Sarcoma, Experimental - immunology</subject><subject>Species Specificity</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Transfection - immunology</subject><subject>Tumor Cells, Cultured</subject><issn>0022-1767</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkEtLxDAUhbNQxnH0JwhZuZHCzWPSZin1MQMjbsZ1SZNbrfRlbrrov1eZWR04fHwczgVbA0iZidzkV-ya6BsADEi9Yiu73QoLsGb1267kvnNEfL_PUnQDNegTBp7mfozcY9cRD238K7uFTxEJh8TdkNpPHHgaT1xGE_q2aT0vn_QDP_Ju6aev0S8J6YZdNq4jvD3nhn28PB_LXXZ4f92Xj4dskmBShtJ4G7wDE2Sdu6B8kYumsVbKWoEHFwoptNlqI12hBEqNUhnhEYNVTQC1Yfcn7xTHnxkpVX1L__vdgONMVW4L0MLoP_DuDM51j6GaYtu7uFTnU9QvCwBdIA</recordid><startdate>19980115</startdate><enddate>19980115</enddate><creator>Armstrong, T D</creator><creator>Clements, V K</creator><creator>Ostrand-Rosenberg, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980115</creationdate><title>MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes</title><author>Armstrong, T D ; Clements, V K ; Ostrand-Rosenberg, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-e26c9dca06d2b7ad3c871ff9922b30c0ad821465462a831e24e2361ceed93fd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antigen Presentation - genetics</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Antigen-Presenting Cells - metabolism</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>Cell Membrane - immunology</topic><topic>Cell Membrane - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic - immunology</topic><topic>Genotype</topic><topic>Histocompatibility Antigens Class II - biosynthesis</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Antigens Class II - metabolism</topic><topic>Intracellular Fluid - immunology</topic><topic>Intracellular Fluid - metabolism</topic><topic>Lymphocyte Activation - genetics</topic><topic>Mice</topic><topic>Mice, Inbred A</topic><topic>Mice, Inbred C57BL</topic><topic>Muramidase - biosynthesis</topic><topic>Muramidase - genetics</topic><topic>Muramidase - immunology</topic><topic>Peptide Fragments - immunology</topic><topic>Peptide Fragments - metabolism</topic><topic>Radiation Chimera - genetics</topic><topic>Radiation Chimera - immunology</topic><topic>Sarcoma, Experimental - genetics</topic><topic>Sarcoma, Experimental - immunology</topic><topic>Species Specificity</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Transfection - immunology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armstrong, T D</creatorcontrib><creatorcontrib>Clements, V K</creatorcontrib><creatorcontrib>Ostrand-Rosenberg, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armstrong, T D</au><au>Clements, V K</au><au>Ostrand-Rosenberg, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1998-01-15</date><risdate>1998</risdate><volume>160</volume><issue>2</issue><spage>661</spage><epage>666</epage><pages>661-666</pages><issn>0022-1767</issn><abstract>We have developed and shown to be efficacious an immunotherapeutic strategy to enhance the generation of tumor-specific CD4+ T helper lymphocytes. The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hypothesis that tumor cells directly present tumor Ags to CD4+ T cells. Since the conventional pathway for CD4+ T cell activation is indirect via professional APC, induction of immunity following immunization with class II-transfected tumor cells was examined in bone marrow chimeric mice. Both tumor and host-derived cells are APC for tumor Ags, suggesting that the efficacy of tumor cell vaccines can be significantly improved by genetic modifications that enhance tumor cell Ag presentation.</abstract><cop>United States</cop><pmid>9551900</pmid><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of immunology (1950), 1998-01, Vol.160 (2), p.661-666 |
| issn | 0022-1767 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antigen Presentation - genetics Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Membrane - immunology Cell Membrane - metabolism Female Gene Expression Regulation, Neoplastic - immunology Genotype Histocompatibility Antigens Class II - biosynthesis Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism Intracellular Fluid - immunology Intracellular Fluid - metabolism Lymphocyte Activation - genetics Mice Mice, Inbred A Mice, Inbred C57BL Muramidase - biosynthesis Muramidase - genetics Muramidase - immunology Peptide Fragments - immunology Peptide Fragments - metabolism Radiation Chimera - genetics Radiation Chimera - immunology Sarcoma, Experimental - genetics Sarcoma, Experimental - immunology Species Specificity T-Lymphocyte Subsets - immunology Transfection - immunology Tumor Cells, Cultured |
| title | MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes |
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