Ventricular Relaxation of Diabetic Spontaneously Hypertensive Rat

Diabetes, and possibly the hypothyroidism that attends diabetes, impairs mechanical relaxation of ventricular muscle, in part by depressing the rate of Ca2+ uptake by sarcoplasmic reticulum. Left ventricular hypertrophy exacerbates the adverse effects of diabetes on cardiac performance, but its effe...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1990-06, Vol.15 (6, Part 1), p.643-651
Hauptverfasser:	Davidoff, Amy J, Pinault, Francine M, Rodgers, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - analysis Blood Pressure Body Weight Calcium - metabolism Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Heart Rate Heart Ventricles - metabolism Heart Ventricles - physiopathology Hypertension - metabolism Hypertension - physiopathology Insulin - blood Male Muscle Contraction Muscle Relaxation Rats Rats, Inbred SHR Rats, Inbred WKY Sarcoplasmic Reticulum - metabolism Streptozocin Triiodothyronine - blood Triiodothyronine - therapeutic use
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