Butyrylcholinesterase Genes in Individuals with Abnormal Inhibition Numbers and with Trace Activity: One Common Mutation and Two Novel Silent Genes

A random population was screened for abnormal dibucaine and fluoride numbers (DN & FN) to find some common mutations in butyrylcholinesterase (BCHE) gene. Of 2375 unrelated individuals, 10 were found to have low DN and FN and were selected for further studies. DNA analysis of these hypocholinest...

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Veröffentlicht in:	Annals of clinical biochemistry 1998-03, Vol.35 (2), p.302-310
Hauptverfasser:	Dey, Dilip Chandra, Maekawa, Masato, Sudo, Kayoko, Kanno, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Butyrylcholinesterase - genetics Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - pharmacology Dibucaine - pharmacology Enzymes and enzyme inhibitors Fluorides - pharmacology Fundamental and applied biological sciences. Psychology Genetic Variation Humans Hydrolases Japan Mutation Polymerase Chain Reaction - methods Polymorphism, Restriction Fragment Length Polymorphism, Single-Stranded Conformational Sequence Analysis, DNA
Online-Zugang:	Volltext
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